Patents Represented by Attorney, Agent or Law Firm Covington & Burling
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Patent number: 7863465Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-?-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.Type: GrantFiled: March 29, 2007Date of Patent: January 4, 2011Assignees: Merck Sharp & Dohme Corp., Scynexis, Inc.Inventors: James M. Balkovec, Frances Aileen Bouffard, Bruno Tse, James Dropinski, Dongfang Meng, Mark L. Greenlee, Michael Peel, Weiming Fan, Ahmed Mamai, Hao Liu, Keqaing Li
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Patent number: 7834042Abstract: A compound having the structure (Formula I), wherein Y is —Y1—Y2—Y3—Y4—Y5—; Y1 is C(O) or C(R1R2); Y2 is O, C(O), P(O)(OH) or CH2, provided that when Y1 is C(O), Y2 is not C(O); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the pup consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y3 is O, C(O) or CH2, provided that when Y2 is C(O), then Y3 is not C(O), and further provided that when Y2 is O, then Y3 is not O; Y4 is O or CH2 or is absent, provided that when Y3 is O, then Y4 is not O; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt thereof, which is useful for treating hypertension.Type: GrantFiled: December 11, 2007Date of Patent: November 16, 2010Assignee: Merck Sharp & Dohme Corp.Inventors: Iyassu K. Sebhat, Michael Man-chu Lo, Ravi P. Nargund, Amjad Ali
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Patent number: 7799345Abstract: Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.Type: GrantFiled: July 19, 2007Date of Patent: September 21, 2010Assignee: Alkermes Controlled Therapeutics, Inc.Inventors: Stephen E. Zale, J. Michael Ramstack, Joyce M. Hotz, M. Gary I. Riley, Olufunmi L. Johnson
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Patent number: 7618649Abstract: A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and (b) a sustained release second layer comprising an effective amount of a nasal decongestant, e.g. pseudoephedrine sulfate and a pharmaceutically acceptable sustained release agent wherein the composition contains less than about 2% of desloratadine decomposition products is disclosed. A solid composition comprising an anti-allergic effective amount of desloratadine and at least one, and preferably two pharmaceutically acceptable antioxidants is also disclosed.Type: GrantFiled: November 3, 2003Date of Patent: November 17, 2009Assignee: Schering CorporationInventor: Wing-Kee Philip Cho
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Patent number: 7612176Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.Type: GrantFiled: July 16, 2007Date of Patent: November 3, 2009Assignee: Alkermes, Inc.Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
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Patent number: 7563871Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.Type: GrantFiled: September 14, 2006Date of Patent: July 21, 2009Assignees: Alkermes, Inc., Amylin Pharmaceuticals, Inc.Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Mark Fineman, Christine Smith, John Ong, David Lokensgard, Henry R. Costantino
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Patent number: 7547452Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an active agent, such as risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing.Type: GrantFiled: July 13, 2007Date of Patent: June 16, 2009Assignees: Alkermes, Inc., Janssen Pharmaceutica, N.VInventors: Thomas J. Atkins, Michael E. Rickey, Jean Mesens
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Patent number: 7524530Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.Type: GrantFiled: April 19, 2007Date of Patent: April 28, 2009Assignee: Alkermes, Inc.Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
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Patent number: 7510730Abstract: Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.Type: GrantFiled: July 16, 2007Date of Patent: March 31, 2009Assignee: Alkermes, Inc.Inventors: Shawn L. Lyons, Steven G. Wright
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Patent number: 7486982Abstract: An apparatus and method for providing RF shielding for performing nuclear magnetic resonance (“NMR”) procedures, comprising a radio-opaque holder in combination with radio-opaque magnet components to form an RF shield around a patient undergoing an NMR procedure. In embodiments, a radio-opaque holder having a radio-opaque bottom portion and a radio-opaque canopy is adjoined to an NMR magnet having a radio-opaque cryostat and a radio-opaque service end cap to form an RF shield. A patient is placed on a patient support unit located in the holder bottom portion. The patient support unit, including the patient, is then inserted into the cavity of the NMR magnet and a canopy is placed on top of the bottom portion of the holder. An RF shield is thus created comprising the canopy, the bottom portion, the cryostat of the magnet, and an end cap on the service end of the magnet.Type: GrantFiled: April 19, 2004Date of Patent: February 3, 2009Assignee: Advanced Veterinary Technologies, Inc.Inventors: Craig A. Branch, Joseph A. Helpern
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Patent number: 7462365Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide, a sugar and a salting-out salt.Type: GrantFiled: October 17, 2003Date of Patent: December 9, 2008Inventors: Henry R. Costantino, Joyce M. Hotz, Edward W. Bobka
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Patent number: 7456254Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.Type: GrantFiled: April 13, 2005Date of Patent: November 25, 2008Assignee: Alkermes, Inc.Inventors: Steven G. Wright, Troy Christenson, Thean Y. Yeah, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
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Patent number: 7416115Abstract: This invention provides a system and method for authorizing automated value transfers from an account available to users who do not have a pre-existing trust, business or financial relationship. In an embodiment of the present invention, a Sender at a first location purchases a PIN Card at a point of sale, such as a retail location or a bank teller. The Sender contacts an intended Recipient at a remote location and discloses a Transfer PIN associated with the PIN Card, as well as the amount being transferred, to that intended Recipient. The Recipient needs only the Transfer PIN and a Cash Card to receive the money transfer at a participating remote location. To receive the value associated with the PIN Card, the Recipient inserts or swipes the Cash Card at an ATM and enters the Transfer PIN. An authorization system then authorizes the dispensing unit to dispense that value amount.Type: GrantFiled: August 15, 2005Date of Patent: August 26, 2008Assignees: American Cash Exchange, L.L.C., American Cash Exchange, Inc.Inventors: Donald C. Licciardello, Lawrence Greenberg, Alex Peterhans, David Romero, Debra Lynn Licciardello
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Patent number: 7371406Abstract: Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.Type: GrantFiled: October 9, 2003Date of Patent: May 13, 2008Assignee: Alkermes Controlled Therapeutics, Inc.Inventors: J. Michael Ramstack, M. Gary I. Riley, Stephen E. Zale, Joyce M. Hotz, Olufunmi L. Johnson
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Patent number: 7300671Abstract: Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.Type: GrantFiled: June 22, 2005Date of Patent: November 27, 2007Assignee: Alkermes, Inc.Inventors: Shawn L. Lyons, Steven G. Wright
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Patent number: 7278425Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.Type: GrantFiled: February 5, 2004Date of Patent: October 9, 2007Assignee: Alkermes, Inc.Inventors: David Edwards, Colleen Conlon, David L. Foshee, Jason R. Durkin, Tim Coker, Kevin Stapleton
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Patent number: 7247319Abstract: Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintaining the microparticles at a conditioning temperature for a period of time. The conditioning can be used with microparticles containing an active agent, and with placebo microparticles, and it is reversible.Type: GrantFiled: December 20, 2001Date of Patent: July 24, 2007Assignee: Alkermes, Inc.Inventors: J. Michael Ramstack, Steven G. Wright, David A. Dickason
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Patent number: 7235542Abstract: Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney disease can be reduced by the administration of iron chelators to humans afflicted with a progressive kidney disease. The methods include measuring catalytic iron content in urine in a human afflicted with a progressive kidney disease and administering an iron chelator to the human. The method can include measuring total urinary protein content, blood urea nitrogen or creatinine in a blood sample before, during or after the administration of an iron chelator.Type: GrantFiled: April 26, 2006Date of Patent: June 26, 2007Assignee: Shiva Biomedical, LLCInventor: Sudhir V. Shah
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Patent number: 7223440Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.Type: GrantFiled: December 21, 2005Date of Patent: May 29, 2007Assignee: Alkermes, Inc.Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
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Patent number: RE40045Abstract: Pharmaceutical compositions comprising effective amounts of salmeterol (and a physiologically acceptable salt thereof) and fluctuations propionate as a combined preparation for simultaneous, sequential or separate administration by inhalation in the treatment of respiratory disorders.Type: GrantFiled: September 3, 2004Date of Patent: February 5, 2008Assignee: Glaxo Group LimitedInventor: James B. D. Palmer