Patents Represented by Attorney, Agent or Law Firm Curtis C. Panzer
  • 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
    Patent number: 4966907
    Abstract: Novel position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: October 30, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Charles G. Caldwell, Milton L. Hammond, Ihor E. Kopka, Stanley H. B. Wright, Robert A. Zambias
  • Welan gum in cement compositions
    Patent number: 4963668
    Abstract: Low viscosity welan gum having a 5% (wt.) aqueous solution viscosity of 100 cP and process for preparation of such are described.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Floyd L. Allen, Glen H. Best, Thomas A. Lindroth
  • Substituted 5-hydroxy-2,3-dihydrobenzothiophenes as inhibitors of leukotriene biosynthesis
    Patent number: 4963580
    Abstract: Position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzothiophenes and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: November 27, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Zambias, Milton L. Hammond
  • 5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs as antiproliferative agents
    Patent number: 4923885
    Abstract: Novel 5-Amino-1-(4-Naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs are disclosed as having antiproliferative activities useful in the treatment and control of psoriasis, inflammatory bowel syndrome, cutaneous leishmanilisis and certain types of cancer.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: May 8, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Donald Hupe, Matthew J. Wyvratt
  • Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
    Patent number: 4914188
    Abstract: Novel cyclosporin analogs containing a MeAla or MeAbu residue at the 6-position of the cyclic undecapeptide have been synthesized and found unexpectedly to exhibit antagonistic activity toward cyclosporin A binding to its cytosolic protein receptor, cyclophilin, without being immunosuppressive.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: April 3, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Francis J. Dumont, Philippe L. Durette, Arsenio A. Pessolano, Joshua S. Boger, Nolan H. Sigal