Abstract: The invention relates to a system and method for assessing simulated biological dissolution of a pharmaceutical formulation and absorption of a pharmaceutically active compound therefrom. The system comprises a dissolution chamber and a cell culture chamber. Within the dissolution chamber, the dissolution profile of the pharmaceutical formulation (or drug) is determined. Within the cell culture chamber, the pharmaceutically active compound may be absorbed and transported by a cell monolayer. The cell culture chamber includes a tubular filter which is permeable to medium and capable of supporting the cell monolayer on its interior surface. Insertion of the filter into the cell culture chamber housing forms an apical chamber interior of the filter, and a basal chamber between the filter and the wall of the housing. The filter rotates about an axis within the housing substantially parallel to the direction of media flow through the cell culture chamber.

Abstract: The charging criteria for determining the price for a call between two subscribers in a cellular mobile telephone network, is improved. One cell, or a group consisting of several cells, is chosen as a group of special cells. Upon establishing a call, a mobile switching center of a calling subscriber analyzes whether the location cell of the calling subscriber and/or that of the called subscriber are members of a group of special cells. If this is the case, the charging criteria determined for the group will be applied. Additionally, private branch exchanges may also be connected to the mobile switching center.

Abstract: The subject invention relates to a set of DNA primers which, when utilized in conjunction with the polymerase chain reaction (PCR) assay, can amplify and speciate DNA from five medically important Candida species. Furthermore, the PCR amplified products, generated by the primers, can also be used to create species specific probes which can also detect and confirm the five species of Candida. Thus, the present invention allows for early diagnosis and treatment of an infection. The assay is useful in the context of monitoring antifungal treatment regimens, screening potential antifungal agents, and similar applications requiring quantitative determinations.

Abstract: The wheel cover for attaching automobile wheels is made of polypropylene containing 20.about.67 wt. %, thermoplastic elastomer containing 3.about.30 wt. % and acicular calcium silicate containing of 30.about.50 wt. %. The acicular calcium silicate is preferred with a filler orientation index that is less than 1000 and has average particle sizes between 1 and 100 .mu.m. The polypropylene resin is high crystallization block polypropylene resin which contains 3.about.12 wt. % of ethylene ingredient. Heat deformed temperature (455 kPa) is more than 125 centigrade degree. It is preferred that the Melt flow index is more than 300 g/10 min.

Abstract: The invention concerns derivatives of the formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is amino-(2-4C)alkylamino, (1-4C)alkylamino, (1-4C)alkylamino-(2-4C)alkylamino,di-[(1-4C)alkyl]amino-(2-4C) alkylamino, pyrrolidin-1-yl-(2-4C)alkylamino, piperidino-(2-4C)alkylamino, morpholino-(2-4C)alkylamino, piperazin-1-yl-(2-4C)alkylamino, or 4-(1-4C) alkylpiperazin-1-yl-(2-4C)alkylamino, or pharmaceutically acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.

Abstract: A weather strip is adhered to a vehicle by a double sided adhesive tape. The weather strip seals between the vehicle body and a door when the door is closed. The weather strip includes a first section extruded from a rubber material, which is vulcanized at a vulcanizing temperature. The weather strip also includes a second section molded from a thermoplastic elastomer at a temperature lower than the vulcanizing temperature. The adhesive tape is applied to the weather strip to span the first section and the second section. This permits a single piece of tape to be continuously applied to the weather strip, which is more efficient.

Abstract: The invention relates to low-molecular, metabolism-activating mixtures of active ingredients from yeast fungi of the order Saccharomycetes and is characterized in that they are obtained from yeasts of the said order of Saccharomycetes, which are cultivated for some hours at temperatures starting at 37.degree. C., are heated to a maximum of 45.degree. C. and, following cooling, are subsequently processed in a manner known per se.

Abstract: The invention relates to isolation of an Aspergillus gene encoding rhamnogalacturonase (RG-ase) and the construction of recombinant Aspergillus strains with overexpression of RG-ase. These strains can be used for the commercial production of RG-ase. RG-ase is an important enzyme in processes requiring the degradation and/or modification of pectin or modification of pectin-containing vegetable or plant cell wall material. RG-ase may be used in various applications, including the processing of fruits and vegetables, in the extraction of components from vegetable material or for improving the functionality of pectin or pectin-containing vegetable material, food material or plant cell wall material.

Abstract: A compound of the formulaC.sup.0 BwhereinC.sup.0 stands for ##STR1## A representing O or 2H, and R.sub.0 representing SH, NH.sub.2, or C.sub.x H.sub.y --SO.sub.2 --NH--, wherein C.sub.x H.sub.y is a straight chain saturated or unsaturated hydrocarbon, with x being between 1 and 20 and y between 3 and 41, inclusive; andB stands for --NHR, where R is an aryl group.The compounds are useful for inhibiting p21ras farnesyltransferase.

Abstract: Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.

Abstract: sigF is a gene that controls M. tuberculosis latency. A diagnostic test for latent tuberculosis involves detecting M. tuberculosis sigF in clinical specimens. Two genes orfX and orfY regulate sigF expression and sigF activity. M. tuberculosis sigF, orfX, and orfY are used in screening methods for potential therapeutic agents which regulate the growth of M. tuberculosis.

Abstract: A process is disclosed for preparing a protein by a eukaryote transformed by multicopy integration of an expression vector into the genome of a yeast, such as Saccharomyces, Hansenula, and Kluyveromyces, or of a mould such as Aspergillus, Rhizopus and Trichoderma, the expression vector containing both an "expressible gene" encoding the protein and a so-called "deficient selection marker needed for the growth of the yeast or mould in a specific medium", such as the LEU2d, TRP1d or URA3d gene, in combination with a ribosomal DNA sequence, resulting in stable high copy integration of 100-300 copies per cell. This multicopy integration results in an increased production of the desired protein, which can be guar .alpha.-galactosidase, an oxidase or a hydrolytic enzyme such as a lipase.

Abstract: Use in cosmetics of lipophilic derivatives of amino deoxyalditols, cosmetic compositions containing them, and novel alkyl carbamates.The invention is characterized by the use in cosmetic compositions of one or more lipophilic derivatives of amino deoxyalditols corresponding to the general formula: ##STR1## in which: R.sup.1 is a saturated linear C.sub.14 -C.sub.40 aliphatic radical;R.sup.2 is a hydrogen atom or a linear C.sub.1 -C.sub.6 alkyl radical;X is an oxygen atom or a methylene radical; andn is an integer from 1 to 5;with the proviso that when X is a methylene radical R.sup.1 contains from 19 to 39 carbon atoms.Application to the preparation of cosmetic compositions for the treatment of keratinous substances and for buccodental hygiene.

Abstract: A console box for storing small articles includes a box body, an outer lid pivotally mounted for opening and closing the box body and an inner lid disposed between the box body and the outer lid. The box body has a first space for storing small articles. The outer lid pivots within a first angle with respect to the box body. The outer lid is box-shaped and has a second space inside. The inner lid has a third space for storing other small articles. The inner lid is located in the second space of the outer lid when the outer lid is closed. The inner lid pivots in accordance with the movement of the outer lid to a second angle that is smaller than the first angle with respect to the box body. The box body according to the present invention may have a stopper for limiting a maximum opening angle of the outer lid.

Abstract: A fuel tank cap structure with reduced casing body weight and improved dimensional accuracy is disclosed. The casing body of the fuel tank cap has a valve chamber, in which a positive pressure valve and a negative pressure valve are received. The casing body includes an outer tubular body and a valve chamber-forming member located inside the outer tubular body. The outer tubular body is joined with the valve chamber-forming member via a horizontal joint member and vertical horizontal members, which are arranged in a hollow portion.

Abstract: Plant nitrogen metabolism in corn and tobacco has been altered by transformation with a highly active assimilatory glutamate dehydrogenase gene. Plants containing the gdhA gene are resistant to phosphinothricin herbicides (PPT) which can include glufosinate herbicides. Additionally, these transformed plants evidence higher levels of tolerance to PPT when combined with another PPT resistant gene. This invention also includes the method of improving plant growth in a field of crops encoding for GDH due to a gdhA transgene.

Abstract: A regime for therapeutic management of a benign prostatic hyperplasia and prostatic cancer employs Cetrorelix alone or in combination with .alpha.-reductase inhibitors or .alpha.-receptor blocking agents. The regimen reduces the volume of the prostate and avoids the side effects associated with testosterone levels being in a castration range. Cetrorelix is administered at dosages between 0,5 mg/day and 20 mg/week or about 0.014 mg/kg body weight per day to 0,30 mg/kg body weight per week or at levels of about 25 to 120 mg of Cetrorelix per month or 0.376 mg/kg to 1.71 mg/kg per month. Cetrorelix can be administered with .alpha.-reductase inhibitors or .alpha.-receptor blocking agents.

Abstract: A fuel tank cap with enhanced sealing property of a valve body of a positive pressure valve, which improves the pressure control ability of the fuel tank cap is disclosed. The positive pressure valve controls the pressure in a fuel tank by opening and closing a rubber valve body. The valve body is supported on its rear face by a valve support member, and is seated on and separated from a seat member. The valve body has a ring recess arranged in an outer circumferential portion thereof to form a thin-wall seating portion, which is seated on the seat member. The valve body is seated horizontally on the seat member, and is supported by the valve support member on both the inner circumferential side and the outer circumferential side of the ring recess.

Abstract: The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.

Abstract: The present invention provides a redundancy circuit in a semiconductor memory device which has spare memory cells which can store information that can be substituted for data of defective memory cells after the completion of the manufacturing process. If addresses designating the defective memory cells are externally input, the redundancy circuit generates a defective cell relief address signal which corresponds to the address designating the defective memory cell and is used to prevent defective data stored in normal memory cells from being output and causes correction data, to be substituted for the defective data output in correspondence with the defective cell relief address.