Patents Represented by Law Firm Cushman Darby & Cushman Intellectual Property Group of Pillsbury Madison & Sutro LLP
  • Patent number: 6063605
    Abstract: Novel strains of the insecticidal microorganism Bacillus thurinaiensis are described. These contain novel genes, and in particular a gene coding for a novel insecticidal endotoxin, 81 kilodaltons in length, toxic to both Lepidoptera and Coleoptera. The novel strains and the genes they contain may be used to combat insect attack against plants.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: May 16, 2000
    Assignee: Zeneca Limited
    Inventors: Susan Ely, Ravindra Haribhai Tailor, Janet Mary Tippett, Bruce Marvin Held, Robert Gerard Blenk, deceased
  • Patent number: 5993859
    Abstract: The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.
    Type: Grant
    Filed: July 13, 1998
    Date of Patent: November 30, 1999
    Assignee: Zeneca Limited
    Inventors: Robert Joseph Timko, Randy John Bradway, Arlene Clements
  • Patent number: 5992669
    Abstract: A fuel tank cap structure and method of manufacturing which prevents a parting line formed on a cover member in the process of injection molding from being undesirably shaven. The fuel tank cap includes a casing body and a cover member that is rotatable in one direction relative to the casing body via a ratchet mechanism when a torque of or above a predetermined level is applied to the cover member. The cover member has fitting projections that are held by an outer ring member of the casing body. A slide mold is used for manufacturing the cover member having the fitting projections that are undercut in the injection molding. This causes a parting line to be formed on a top wall of the cover member. Anti-shaving projections formed at substantially the same height as that of the parting line prevent the parting line from being slid against the outer ring member and shaven.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: November 30, 1999
    Assignee: Toyoda Gosei Co., Ltd.
    Inventors: Hiroyuki Hagano, Masayuki Nakagawa
  • Patent number: 5992672
    Abstract: A fuel tank cap structure which enables a cover member to be readily attached to a casing body. The fuel tank cap includes the casing body and the cover member that is rotatable in one direction relative to the casing body via a ratchet mechanism when a torque of or above a predetermined level is applied to the cover member. The cover member has fitting projections that are held by an outer ring member of the casing body. The outer ring member has a plurality of slits, which cause the outer ring member to be elastically deformed when riding over the fitting projections, thereby facilitating the engagement of the fitting projections with the outer ring member.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: November 30, 1999
    Assignee: Toyoda Gosei Co., Ltd.
    Inventors: Hiroyuki Hagano, Masayuki Nakagawa
  • Patent number: 5985281
    Abstract: A two component system for therapeutic treatment of a host, having a first component comprising a targeting moiety capable of binding with a tumour associated antigen, linked to a mutated enzyme capable of converting a prodrug into an antineoplastic drug, and a second component comprising a prodrug convertible under the influence of the mutated enzyme to the antineoplastic drug. The mutated enzyme is a mutated form of a natural host enzyme which recognizes its natural substrate by an ion pair interaction with the substrate, wherein the mutated enzyme and prodrug have structures such that the polarity of the mutated enzyme/prodrug ion pair interaction is reversed relative to the natural host enzyme/natural substrate ion pair interaction. The first component is substantially non-immunogenic in the host and the prodrug second component is not significantly convertible into antineoplastic drug in the host by natural unmutated host enzyme.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: November 16, 1999
    Assignee: Zeneca Limited
    Inventors: Christopher John Taylorson, Hendrikus Johannes Eggelte, Antonio Tarragona-Fiol, Brian Robert Rabin, Francis Thomas Boyle, John Frederick Hennam, David Charles Blakey, Peter Robert Marsham, David William Heaton, David Huw Davies, Anthony Michael Slater, Laurent Francois Andre Hennequin
  • Patent number: 5980501
    Abstract: A passive reservoir for medicament in the form of a plastics bag 1, has a hanging eyelet 2 at its upper end and a lower outlet nozzle 3. The plastics bag 1 has bottom corners 4,5, the left-hand right-angled corner 5 of which encapsulates a data carrier means 6 which carries data relating to a medicament contained or to be contained within the bag 1. The data carrier means is in the form of an electrically and/or magnetically operable device which can emit the data it is carrying in response to activation by a suitable field applied by an external reading device, which can cooperate with a delivery device to control the delivery to a patient of medicament when contained in the bag 1.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: November 9, 1999
    Assignee: Zeneca Limited
    Inventor: John M Gray
  • Patent number: 5975328
    Abstract: A fuel cap structure which enables part of a flange member to be readily broken when an external force is applied via a cover member in any direction. A fuel cap includes a casing body and a cover member attached to the flange member formed on the upper portion of the casing body. The flange member includes a joint member to join the upper portion of the casing body with an outer ring member, in which the cover member is fitted. The joint member has fragile portions including notches. Each fragile portion starts a break of the joint member when an external force is applied to the flange member via the cover member in a variety of directions.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: November 2, 1999
    Assignee: Toyoda Gosei Co., Ltd.
    Inventors: Hiroyuki Hagano, Masayuki Nakagawa
  • Patent number: 5965539
    Abstract: Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: October 12, 1999
    Assignee: Univeristy of Pittsburgh
    Inventors: Said Sebti, Andrew Hamilton
  • Patent number: 5965559
    Abstract: The invention concerns compounds of formula (I), wherein each of G.sup.1, G.sup.2 and G.sup.6 is CH or n; m is 1 or 2; R.sup.1 includes hydrogen, halogeno and (1-4C)alkyl; M.sup.1 is a group of formula: NR.sup.2 -L.sup.1 -T.sup.1 R.sup.3, in which R.sup.2 and R.sup.3 together form a (1-4C)alkylene group, L.sup.1 includes (1-4C)alkylene, and T.sup.1 is CH or N; A may be a direct link; M.sup.2 is a group of the formula: (T.sup.2 R.sup.4).sub.r -L.sup.2 T.sup.3 R.sup.5 in which R is 0 or 1, each of T.sup.2 and T.sup.3 is CH or N, each of R.sup.4 and R.sup.5 is hydrogen or (1-4C)alkyl, or R.sup.4 and R.sup.5 together form a (1-4C)alkylene group, and L.sup.2 includes (1-4C)alkylene; M.sup.3 may be a direct link to X; X includes sulphonyl; and Q includes naphthyl and a heterocycle moiety; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use as antithrombotic or anticoagulant agents.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: October 12, 1999
    Assignee: Zeneca Limited
    Inventors: Alan Wellington Faull, Andrew Stocker, Colette Marie Mayo, John Preston
  • Patent number: 5955464
    Abstract: The invention concerns 4-anilinoquinazoline derivatives of the formula I ##STR1## wherein m is 1 or 2; each R.sup.1 includes hydrogen, halogeno, (1-4C)alkyl and (1-4C)alkoxy;n is 1, 2 or 3;each R.sup.2 includes hydrogen, hydroxy, halogeno and (1-4C)alkyl; and Ar is a 5- or 9-membered nitrogen-linked heteroaryl moiety containing up to four nitrogen heteroatoms, or Ar is a 5-, 6-, 9- or 10-membered nitrogen-linked unsaturated heterocyclic moiety containing up to three nitrogen heteroatoms which bears one or two substituents selected from oxo and thioxo such as 2-oxo-4-imidazolin-1-yl;or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: September 21, 1999
    Assignee: Zeneca Limited
    Inventor: Andrew John Barker
  • Patent number: 5952333
    Abstract: The invention concerns the quinazoline derivative 6-(2-methoxyethylamino)-7-methoxy-4-(3'-methylanilino)quinazoline, or a pharmaceutically-acceptable salt thereof, processes for its preparation, pharmaceutical compositions containing the compound and the use of the receptor tyrosine kinase inhibitory properties of the compound in the treatments of proliferative disease such as cancer.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Zeneca Limited
    Inventor: Andrew John Barker
  • Patent number: 5939255
    Abstract: Yeast Artificial Chromosomes (YACS) containing DNA encoding the cystic fibrosis (CFTR) gene are described. The YACs allow detailed analysis of the coding and non-coding regions of the gene and the determination of cystic fibrosis alleles in sample DNA from an individual or individuals.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 17, 1999
    Assignee: Zeneca Limited
    Inventors: Rakesh Anand, Alexander Fred Markham, John Craig Smith, Rashida Anwar, John Hamilton Riley, Donald James Ogilvie, Paul Elvin
  • Patent number: 5932574
    Abstract: The invention concerns quinazoline derivatives of formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is di-?(1-4C)alkyl!amino-(2-4C)alkoxy, pryolidin-1-yl-(2-4C)alkoxy,piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: October 25, 1997
    Date of Patent: August 3, 1999
    Assignee: Zeneca Limited
    Inventor: Andrew John Baker
  • Patent number: 5925569
    Abstract: This invention relates to the measurement of various haemostatis, clotting, and the like properties of blood.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: July 20, 1999
    Assignee: Xylum Corporation
    Inventors: Peter Gorog, Iren Kovacs
  • Patent number: 5919647
    Abstract: An apparatus including: a sprayer for inoculating a microbe on a first division divided from at least one sample of a plant to be examined; sample leaving device for leaving a second division divided from the sample not inoculated with the microbe and the first division inoculated with the microbe, for a predetermined period of time under a predetermined condition; first and second photodetector for respectively measuring the quantities of luminescence emitted from the first and second divisions which have been left standing by the sample leaving device; and a computer for comparing the quantities of the luminescence measured by the first and second photodetector, thereby to examine the resistance or susceptibility of the plant to the microbe.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: July 6, 1999
    Assignees: Hamamatsu Photonics K.K., Shizuoka Prefecture
    Inventors: Mitsuo Hiramatsu, Kazuyoshi Ohta, Takahiro Makino, Kimihiko Kato, Sakio Suzuki, deceased
  • Patent number: 5919793
    Abstract: Compounds of formula (I) wherein R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen; or R.sup.1 and R.sup.2 are joined together so that CR.sup.1 14 CR.sup.2 is a double bond; X is selected from --Ch.sub.2 CH.sub.2 --, --C.dbd.CH--, --C.tbd.C--, --CH.sub.2 O--, --OCH.sub.2, CH.sub.2 NH--, --NHCH.sub.2 --, --CH.sub.2 CO--, --COCH.sub.2 --, --CH.sub.2 S(O).sub.n -- and --S(O).sub.n CH.sub.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 6, 1999
    Assignee: Zeneca Limited
    Inventors: George Robert Brown, Paul Robert Owen Whittamore, David Robert Brittain
  • Patent number: 5912355
    Abstract: Method of preparing an optically active compound of formula, wherein R and R.sup.1 are independently alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, aryl, aralkyl, a heterocyclic group or a C.sub.1 -C.sub.4 alkyl-heterocycle, each being optionally substituted, procided that R and R.sup.1 are not identical and * is an optically active chiral center, from the corresponding racemic ester or diol by treating with a hydrolase enzyme.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: June 15, 1999
    Assignees: Zeneca Limited, Mochida Pharmaceutical Co., Ltd.
    Inventors: Andrew John Blacker, Andrew George Brewster, Robert Jeffrey Copeland, Robert Antony Holt
  • Patent number: 5908869
    Abstract: Pharmaceutical compositions containing 2,6-diisopropylphenol (propofol) are described for use as anaesthetics. A method for their preparation is described, as their use in producing anaesthesia including induction and maintenance of general anaesthesia and sedation.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: June 1, 1999
    Assignee: Zeneca Limited
    Inventors: Christopher Buchan Jones, John Henry Platt
  • Patent number: 5904265
    Abstract: The invention relates to a tank with an inner and/or outer cladding or lining, consisting of a tank wall and a double-walled cladding adhering to the latter and consisting of a double pile fabric which is reinforced by a curable impregnated resin and in which an upper and a lower fabric are connected so as to be spaced from one another by means of webs formed by pile threads, and with a closing-off laminate ply, the webs of the cladding forming, between the upper and the lower fabric, web walls extending linearly in one direction and consisting in each case of a multiplicity of pile threads arranged next to one another, and the web walls extending parallel to one another with small web heights of about 2.5 to 3.5 mm and with web wall spacings, greater than these of about 5 to 8 mm and, together with the upper and the lower fabric, delimiting individual cavity ducts.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: May 18, 1999
    Assignee: Parabeam Industrie-En Handelsonderneming BV
    Inventors: Jaap A. Zandbergen, Cornelius T.J.M. Swinkels
  • Patent number: RE36617
    Abstract: A (substituted-aralkyl)heterocyclic compound of the formula I ##STR1## wherein R.sup.1 is an azido, carbamoyl, cyano, formyl, hydroxy or nitro radical, a 1-6C 1-hydroxyalkyl, alkoxy, alkylcarbamoyl, alkylthio, alkylsulphinyl or alkylsulphonyl radical, a 2-cyanoethyl radical, optionally bearing one to four 1-6C alkyl substituents, or a 2-6C alkanoyl, halogenoalkanoyl, alkanoyloxy, alkanoylamino, dialkylcarbamoyl or alkoxycarbonyl radical; R.sup.2 and R.sup.3, which may be the same or different, are each a hydrogen atom, a 1-6C alkyl, dueterioalkyl or halogenoalkyl radical, or a phenyl or phenyl(1-6C alkyl) radical, in each of which the phenyl may optionally bear one or more substituents; or R.sup.2 and R.sup.3, together with the carbon atom to which they are attached, may form a 3- to 6-membered ring; or R.sup.1 R.sup.2 R.sup.3 C- is a 1,1-dicyanoethyl or trifluoromethylsulphonyl radical; R.sup.4 is a hydrogen or halogen atom, a cyano or nitro radical or a 1-6C alkyl or halogenoalkyl radical; R.sup.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: March 14, 2000
    Assignee: Zeneca Limited
    Inventors: Philip N. Edwards, Michael S. Large