Abstract: Disclosed are compositions and methods for enhancing the yield of coagulated milk products including cheese and other fermented milk products. Admixture of structurally expanded celluloses into milk allows substantial incorporation of additional whey solids and fluids into the caseinate matrix. The resulting interactive particle network comprising the cellulosic microfibril substructure and caseinate curd is readily manipulated by standard methods employed in the dairy industry to produce a variety of natural and processed dairy products with increased yield.
Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.
Abstract: The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of tissue invasion and metastatic capacity.
Type:
Grant
Filed:
June 13, 2003
Date of Patent:
September 14, 2010
Assignees:
Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid Ciudad Universitaria de Cantoblanco CRTA.
Inventors:
Amparo Cano García, Ma Angela Nieto Toledano, Ma Isabel Rodrigo Castro, Annamaria Locascio, Marta Garcí a del Barrio, Marí a José Blanco Fernandez de Valderrama, Francisco Portillo Pé rez, Mirna Alicia Pé rez Moreno
Abstract: A method and system are provided for effecting interactive, three-dimensional renderings of selected body organs for purposes of medical observation and diagnosis. A series of CT images of the selected body organs are acquired. The series of CT images is stacked to form a three-dimensional volume file. To facilitate interactive three-dimensional rendering, the three-dimensional volume file may be subjected to an optional dataset reduction procedure to reduce pixel resolution and/or to divide the three-dimensional volume file into selected subvolumes. From a selected volume or subvolume, the image of a selected body organ is segmented or isolated. A wireframe model of the segmented organ image is then generated to enable interactive, three-dimensional rendering of the selected organ.
Abstract: Compositions and methods for detecting and treating cancers expressing Mullerian inhibiting substance Type II receptor (MISIIR) are provided.
Type:
Grant
Filed:
January 9, 2006
Date of Patent:
August 24, 2010
Assignee:
Fox Chase Cancer Center
Inventors:
Gregory P. Adams, Heidi H. Simmons, Qing-an Yuan, Wayne Marasco, Smita Mehta
Abstract: Nucleotide sequences for seven genes, tccC4, tcdA3, tcdA2, tcdB2, tccC3, tcdA4, tccC5, from the tcd genomic region of Photorhabdus luminescens W-14, are useful in heterologous expression of orally active insect toxins.
Type:
Grant
Filed:
July 31, 2007
Date of Patent:
August 17, 2010
Inventors:
Richard H. ffrench-Constant, Nicholas R. Waterfield
Abstract: A storm panel is provided for shielding a structure. The storm panel includes at least one corrugation, and comprises a first wall and a second wall disposed in spaced-apart relation. An angled wall is disposed between and connected to the first wall and the second wall to support the second wall away from the first wall. At least one ridge is disposed proximate the point of connection between the second wall and the angled wall, and may have a shape configured to strengthen the panel proximate the point of connection between the second wall and the angled wall. In addition, a storm panel assembly is provided comprising at least one storm panel and a mounting extrusion for attachment to the storm panel to provide support for the storm panel on a mounting surface, such as the side of a building.
Type:
Grant
Filed:
August 24, 2007
Date of Patent:
August 17, 2010
Inventors:
Shawn Milliken, Les Milliken, Kim Smiley
Abstract: A method and apparatus are provided for processing sets of sheets. The apparatus includes a frame, a hopper for moving a stack of sheets, a pre-singulator for separating a portion of a sheet from the stack, a sheet peeler for peeling part of a pre-singulated sheet from the stack, a sheet picker for gathering peeled sheets into a set, and a sheet discharger for clearing the set of sheets. The sheet peeler may include at least one rotating drum. The sheet picker may include one or more augers.
Abstract: Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.
Type:
Grant
Filed:
April 4, 2007
Date of Patent:
August 10, 2010
Assignee:
Trustees of the University of Pennsylvania
Inventors:
Peter Wilding, Larry J. Kricka, Jay N. Zemel
Abstract: A method and apparatus for processing mail is provided. A stack of mail is placed in an input bin in a feeder module. A feeder serially feeds the envelopes into a transport path. The envelopes are then examined to determine if the contents are qualified for extraction. Envelopes that are qualified for extraction are opened in a cutting module and then conveyed to an extraction module to extract the contents from the envelopes. The contents may then be scanned and reoriented as desired so that the contents are in a pre-determined orientation. The contents are then sorted into a stacker.
Type:
Grant
Filed:
December 10, 2004
Date of Patent:
August 3, 2010
Assignee:
Opex Corporation
Inventors:
Thomas F DiBiaso, Robert R. DeWitt, George L. Hayduchok
Abstract: A motor has an engine block with cylinders arranged to fire in a firing order. A recirculation system delivers combusted mixture from a cylinder which has just fired to at least partly mix with fuel for the next cylinder in the firing order. Injector bodies (401-405) are associated with each cylinder. Each injector body (401-405) has an internal chamber (424) in communication with a fuel inlet port (426) for delivering fuel into the internal chamber, a fuel outlet port (428) for delivering fuel under pressure from the chamber into the associated cylinder and a combusted mixture out-let port (442). The combusted mixture outlet port (442) of each injector body (401-405) is fluidly connected to the combusted mixture inlet port (438) of the next cylinder in the firing order. Alternatively, the recirculation system is arranged substantially internally within the cylinder head.
Abstract: An object name system (ONS) for locating one or more servers associated with an Electronic Product Code (EPC) is described. The system utilizes translation format strings to translate an EPC to an EPC domain prefix. The ONS server matches the EPC number to the address of a second server which has extensive information about the product. The second server recognizes the incoming EPC's as belonging to a particular object or service.
Type:
Grant
Filed:
October 10, 2008
Date of Patent:
July 27, 2010
Assignee:
Massachusetts Institute of Technology
Inventors:
Sanjay Sarma, Daniel W. Engels, Erik L. Nygren, Joseph T. Foley, David L. Brock, Kai-Yeung Sai
Abstract: The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
Type:
Grant
Filed:
January 9, 2008
Date of Patent:
July 6, 2010
Assignee:
Merck Patent GmbH
Inventors:
Matthew Baker, Francis J. Carr, Koen Hellendoorn, Jeannick Cizeau, Glen Christopher MacDonald, Joycelyn Entwistle, Denis Georges Bosc, Nicholas Ronald Glover
Abstract: A solderable cover for solder attachment to an electronic substrate comprises a non-solderable cover defining an attachment pattern, a solderable metal layer in the shape of the attachment pattern, and a layer of adhesive bonding the solderable metal layer to the attachment pattern of the non-solderable cover, wherein the adhesive exhibits bond strength and resiliency sufficient to maintain the solderable metal layer attached to the non-solderable cover when raised in temperature to a melting temperature of a solder.
Abstract: A system, and computer implemented method are provided for interactively displaying three-dimensional structures. Three-dimensional volume data (34) is formed from a series of two-dimensional images (33) representing at least one physical property associated with the three-dimensional structure, such as a body organ having a lumen. A wire frame model of a selected region of interest is generated (38b). The wireframe model is then deformed or reshaped to more accurately represent the region of interest (40b). Vertices of the wire frame model may be grouped into regions having a characteristic indicating abnormal structure, such as a lesion. Finally, the deformed wire frame model may be rendered in an interactive three-dimensional display.
Type:
Grant
Filed:
November 24, 1999
Date of Patent:
June 29, 2010
Assignee:
Wake Forest University Health Sciences
Inventors:
David J. Vining, Gordon W. Hunt, David K. Ahn, David R. Stelts, Yaorong Ge, Paul F. Hemler, Tiffany W. Salido
Abstract: Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
Type:
Grant
Filed:
December 23, 2008
Date of Patent:
June 29, 2010
Assignee:
Indiana University Research and Technology Corporation
Abstract: A precipitation hardenable nickel base alloy that provides a novel combination of elevated temperature strength, ductility, and reduced notch sensitivity at temperatures up to about 1300° F. is described. The alloy contains, in weight percent, about Carbon 0.10 max. Manganese 0.35 max. Silicon 0.2-0.7 Phosphorus 0.03 max. Sulfur 0.015 max. Chromium 12-20 Molybdenum 4 max. Tungsten 6 max. Cobalt 5-12 Iron 14 max. Titanium 0.4-1.4 Aluminum 0.6-2.6 Niobium 3-7 Boron 0.003-0.015 the balance being nickel and usual impurities. An article made from the alloy and a method of making the alloy are also disclosed.