Abstract: This invention relates to hydrogen production using combined heat pumps and a thermochemical cycle. Low grade waste heat can be upgraded to higher temperatures via salt/ammonia and/or MgO/vapor chemical heat pumps, which release heat at successively higher temperatures through exothermic reactions, or vapor compression heat pumps that upgrade thermal energy with phase change fluids. Using this new approach, low grade heat or waste heat from nuclear or other industrial sources can be transformed to a useful energy supply for thermochemical hydrogen production.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: The present invention provides a compound selected from compounds of formula I as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy. Compounds of formula (I) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events, heart valvular degenerative disease Moreover, compounds of formula (I) can be used to decrease the side effects from cytotoxic cancer agents and to treat viral infections.

Abstract: Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.

Abstract: A method and apparatus for processing mail is provided. Mail is placed into an input bin having a conveyor that conveys the mail towards a feeder. The feeder serially feeds the envelopes by engaging the lead envelope in the stack of mail and displacing the lead envelope transverse the stack of mail. The mail is then cut on a side edge and the top edge to cut open each envelope. A transport conveys the cut envelopes to an extractor. The extractor opens the edge-severed mail and presents the contents of the envelopes to an operator who manually extracts the contents. The operator drops the extracted contents onto a conveyor that conveys the contents to an imaging station. The contents are automatically separated and imaged to obtain image data for the contents. The contents are then sorted into a plurality of output bins.

Abstract: A multiple tap attenuator microchip device is disclosed. The device includes a substrate having two or more attenuator taps formed on a surface of the substrate. One or more ground contacts are also formed on the substrate surface and operatively connected to the attenuator taps. The attenuator taps each include a resistive network that is configured to provide a level of attenuation of an rf signal applied to the attenuator tap that is different from the attenuation level provided by the other attenuator tap(s).

Abstract: A dynamic control system for a marine vessel having two or more waterjet units as the primary propulsion system of the vessel, for maintaining vessel position or velocity when in a dynamic control mode, comprises a position or velocity indicator to indicate vessel position or velocity or deviations in vessel position or velocity; such as a satellite-based positioning system indicator, or accelerometers as a relative position indicator, a heading indicator to indicate vessel heading from position heading or yaw rate or deviations in vessel heading or yaw rate, such as a compass as an absolute heading indicator or a yaw rate sensor as a relative heading indicator, and a controller to control the operation of the waterjet units to substantially maintain the vessel position or velocity, and vessel heading or yaw rate when the dynamic control mode is enabled.

Abstract: The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugated amino derivatives, and processes for preparing the same. Pentacyclic compounds may be prepared using the aziridine aldehydes of the present invention, and the invention relates to these compounds and the processes by which they are made. The invention also relates to aziridine-conjugated bioactive molecules, such as amino acids and peptides, and processes for preparing such compounds.

Abstract: A steering system for a marine vessel includes one or more steering devices operable to turn a marine vessel; a steering input device arranged to generate a desired turn rate signal; a rate sensor arranged to generate a turn rate signal indicative of vessel turn rate; and a control system configured to receive the vessel and desired turn rate signals and to control the steering device(s) to turn the marine vessel so as to minimise any difference between the signals.

Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.

Abstract: This invention discloses a process for making nanopanticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in an nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired.

Abstract: The present invention provides a radio system and a method for relaying radio signals, providing a power calibration of transmit radio signals. With the radio system and the method no dedicated calibration signal generator is required for providing the power calibration of the transmit radio signals. The radio system comprises at least one transmit path, a calibration unit at the least one link and a power sensor. A selected one of coupled transmit signals is forwarded to a power sensor for measuring a power level of a portion of the selected one of the coupled transmit signals, wherein the calibration unit is adapted to update a power rating of the at least one transmit path in response to the transmit power level of the selected one of the coupled transmit signals.

Abstract: Herbal skin care compositions for the promotion of wound healing is provided.

Abstract: A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.

Abstract: A method and apparatus for determining weight of a payload lifted by a rig of a load lifting machine. The weight is determined from at least one parameter being or indicative of the force or pressure existing in or applied by the rig while the payload is lifted and a compensation for friction and/or other losses in the rig 14.

Abstract: A scraper blade for a conveyor may comprise: a blade body having a scraping edge and a base for mounting the scraper blade on a blade mount of a conveyor, wherein the blade body has a plurality of elongated recessed features extending across the rearward side thereof, wherein the elongated recessed features are spaced apart and are generally parallel to the scraping edge. Additionally, the base of the blade body may be affixed to a scraper blade mount having a shape of a “flattened W” defining a groove that has beveled edges to provide clearance for a fillet weld of a scraper blade support bar to which the scraper blade is mountable.

Abstract: The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the N-terminus.

Abstract: Nucleic acids encoding spider glue proteins and methods of use thereof are disclosed.

Abstract: Compositions and methods relating to the diagnosis and treatment of neuropsychiatric disorders, such as schizophrenia, schizoaffective disorders, and bipolar disorders are disclosed. Also provided are methods for screening therapeutic agents having efficacy for the treatment of such disorders.