Abstract: The invention provides a method of preventing the formation of inhibitory antibodies in a mammal undergoing gene therapy. The method comprises administering to the mammal an immunosuppressive agent in conjunction with the gene therapy.
Type:
Grant
Filed:
June 8, 2000
Date of Patent:
November 22, 2011
Assignee:
The Children's Hospital of Philadelphia
Inventors:
Katherine A. High, Paul A. Fields, Valder R. Arruda, Roland W. Herzog
Abstract: Ligand-modified poly oxo-hydroxy metal ion materials and their uses are disclosed, in particular for nutritional, medical, cosmetic or biologically related applications for example for the treatment of a deficiency related to a component of the material or for the removal of an endogenous substance capable of binding to the material. The present invention further relates to processes for preparing the materials and optimising their physico-chemical properties and their medical uses.
Type:
Grant
Filed:
February 6, 2008
Date of Patent:
November 15, 2011
Assignee:
Medical Research Council
Inventors:
Jonathan Joseph Powell, Sylvaine Francoise Bruggraber, Nuno Jorge Rodrigues Faria, Dora Isabel Amaral Pereira
Abstract: A chain has a resin member integrally molded on an inner circumferential surface of a bushing with a strong joining force between the resin member and an inner circumferential surface of the bushing. The chain has an inner link in which both end portions of a pair of front and rear bushings are press-fitted into bushing holes of a pair of right and left inner plates, and an outer link in which both end portions of a pair of front and rear pins are press-fitted into pin holes of a pair of right and left outer plates. The inner and outer links are alternately connected to each other in a longitudinal direction of the chain. The inner circumferential edge portions 112a of both end portions of the bushing 112 are chamfered, and the bushing is lined with the resin member 115 insert-molded on an inner circumferential surface of the bushing 112 to produce flared ends, and a central portion of the lined bushing 112 between the ends thereof becomes thicker.
Abstract: A combination of doll and flotation device for demonstrating water safety employs a doll of human-like form sufficiently heavy to sink in water. A removable flotation device which fits the doll, such as a life jacket is designed to be placed on the doll and secured by fasteners such as the Velcro® fixed to opposed edges along the closure gap in the life vest. The life vest, or other flotation device, must be sufficiently buoyant to support the doll as well as it's own weight. The combination has utility in teaching children and adults life saving using familiar devices used in water safety. It allows the student to apply the flotation device to the doll, and remove it as required, and place the doll in the water to float with the flotation device or sink without it.
Abstract: Methods and apparatus for reconstructing a wave, including interpolation and extrapolation of the phase and amplitude distributions, with application to imaging apparatus, such as microscopes.
Type:
Grant
Filed:
November 2, 2007
Date of Patent:
October 18, 2011
Assignee:
Wavefront Analysis, Inc.
Inventors:
Ralph W. Gerchberg, Louise Gerchberg, legal representative
Abstract: An interference canceller between a transmit chain and a receive chain of a transceiver is proposed to complement the action of a diplexer, or duplex filter, that is part of the transceiver. The interference canceller comprises a transmit chain tap, a receive chain coupler for coupling an interference compensation signal into the receive chain, and an interference signal processing path between the transmit chain tap and the receive chain coupler. The interference signal processing path comprises a filter having filtering characteristics similar or corresponding to the filtering characteristic of a receive portion of said diplexer. A corresponding method for interference cancellation is also proposed. Computer-program products for the manufacture of the interference canceller and the execution of the method are also proposed.
Abstract: A wear resistant, heat resistant conveyor chain comprising a series of links, each having a heat resistant roller rotatably fitted onto a bush between inner plates. The links are interconnected in the longitudinal direction of the chain by outer plates, and connecting pins rotatably inserted into the bush. A wear resistant, heat resistant sleeve-shaped spacer protrudes beyond the end surfaces of the heat resistant rollers toward the right and left inner plates to eliminate any sliding contact between the end surface of the heat resistant roller and the inner side surface of the inner plate.
Abstract: A system for safely and humanely anesthetizing and/or euthanizing animals is provided. The system provides both manual and automated operation and may be scaled up to accommodate a large number of animals during a single procedure. The system includes a chamber 20 for receiving an animal to be anesthetized or euthanized and a supply of gas is provided for the chamber, and a fluid controller (65, 165, 265, 365) controls the flow of gas to the chamber. In one embodiment, a valve (75) controls the flow of exhaust air to the chamber.
Type:
Grant
Filed:
October 14, 2008
Date of Patent:
October 4, 2011
Assignee:
Euthanex Corporation
Inventors:
David S. Anderson, Leslie B. Anderson, Cullen L. Speakman
Abstract: The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.
Abstract: A vehicle seat is disclosed which comprises a seat cushion (1), first and second seat backs (2, 3) separated from each other in a vehicle width direction and pivotally supported to the seat cushion (1), a first recliner device (22) for allowing the first seat back (2) to be pivoted in a forward/rearward direction with respect to the seat cushion (1), and a second recliner device (34) for allowing the second seat back (3) to be pivoted in the forward/rearward direction with respect to the seat cushion (1).
Type:
Grant
Filed:
September 26, 2007
Date of Patent:
September 20, 2011
Assignees:
TS TECH Co., Ltd., HONDA MOTOR Co., Ltd.
Abstract: A corrosion resistant, martensitic steel alloy having very good cold formability is described. The alloy has the following weight percent composition. Carbon 0.10-0.40 Manganese 0.01-2.0? Silicon ?2.0 max. Phosphorus ?0.2 max. Sulfur 0.030 max.? Chromium 10-15 Nickel ?0.5 max. Molybdenum 0.75-4.0? Nitrogen 0.02-0.15 Copper 1.5-4.0 Titanium 0.01 max. Aluminum 0.01 max. Niobium + Tantalum 0.10 max. Vanadium 0.20 max. Zirconium less than 0.001 Calcium less than 0.001 The balance of the alloy is essentially iron. Nickel and copper are balanced in the alloy such that the ratio Ni/Cu is less than 0.2. A second embodiment of the alloy contains at least about 0.005% sulfur, selenium, or a combination thereof to provide good machinability.
Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.
Type:
Grant
Filed:
September 7, 2004
Date of Patent:
September 13, 2011
Assignee:
Board of Regents of the University of Nebraska by and Behalf of the University of Nebraska Medical Center
Inventors:
Elena V. Batrakova, Serguei V. Vinogradov, Alexander V. Kabanov
Abstract: A method and apparatus are provided for thawing and heating biological material such as plasma, bone marrow or stem cells. The apparatus includes a housing containing a fluid-filled, sealed bladder for receiving a bag of the biological material. An agitator is provided which is operable to inflate an actuator pillow causing a support plate to compress the fluid-filled bladder, thereby promoting movement of the fluid within the bladder to agitate the biological material. A heater is provided which heats the fluid while contained in the bladder.
Abstract: An antenna array (10) for the transmission of signals (20) is disclosed. The antenna array (10) comprises: a plurality of transmission paths (30-1, 30-2, 30-K) for transmitting a plurality of wanted signals (25) and at least one calibration signal generator (40-1, 40-2, 40-K) for the generation of at least one calibration signal (45). A plurality of calibration signal mixers (50-1, 50-2, 50-K) mixes the at least one calibration signal (45) with the plurality of wanted signals (25) to produce a plurality of transmission signals (20). A path sum signal device (60) sum the plurality of transmission signals (20) to produce a summed transmission signal (65); and an interference estimator (90) accepts the at least one calibration signal (45) and generates an estimated interference signal (92).
Type:
Grant
Filed:
June 18, 2009
Date of Patent:
August 30, 2011
Assignee:
Ubidyne, Inc.
Inventors:
Johannes Schlee, Martin Weckerle, Georg Schmidt, Maik Riegler
Abstract: The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
Type:
Grant
Filed:
December 3, 2009
Date of Patent:
August 30, 2011
Assignee:
Biotica Technology Limited
Inventors:
Christoph Hendrik Beckmann, Steven James Moss, Rose Mary Sheridan, Mingqiang Zhang, Barrie Wilkinson
Abstract: A rechargeable flashlight and charging assembly are provided in which the charger has a receptacle for vertically receiving a flashlight therein. The charger further has a second receptacle for holding an auxiliary battery, and a latch for securely holding the auxiliary battery in the second receptacle. The flashlight is formed to removably contain a battery assembly. A pivotal cover member of the flashlight provides access to the battery compartment and has a pair of conductors situated therein for connection to charging contacts within the charging receptacle.