Patents Represented by Attorney David E. Frankhouser
  • Patent number: 5366972
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: November 22, 1994
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Patent number: 5358954
    Abstract: Pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid compounds which are useful for treating a human host suffering from anxiety.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: October 25, 1994
    Assignee: Boehringer Ingelheim Italia
    Inventors: Marco Turconi, Arturo Donetti, Ernesto Montagna, Massimo Nicola, Annamaria Uberti, Rosamaria Micheletti, Antonio Giachetti
  • Patent number: 5354659
    Abstract: A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: October 11, 1994
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Robert Rothlein, Steven D. Marlin
  • Patent number: 5347020
    Abstract: The invention relates to a new process for the preparation and purification of thermolabile compounds.
    Type: Grant
    Filed: February 3, 1993
    Date of Patent: September 13, 1994
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Michael Aigner, Wolfgang Dersch, Dieter Reichert, Horst Schwall, Werner Warth
  • Patent number: 5302693
    Abstract: The invention relates to a process for preparing poly-D,L-lactide and its use as a carrier for active substances.
    Type: Grant
    Filed: June 19, 1991
    Date of Patent: April 12, 1994
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Stricker, Dieter Bendix
  • Patent number: 5302694
    Abstract: The present invention relates to a method of producing polyesters based on hydroxycarboxylic acids, more particularly based on .alpha.-hydroxycarboxylic acids.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: April 12, 1994
    Assignee: Boehringer Ingelheim GmbH
    Inventor: Berthold Buchholz
  • Patent number: 5292753
    Abstract: The invention relates to the separation of enantiomers of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: March 8, 1994
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Wolfgang Resemann, Adolf Durr, Gunther Engelhardt, John F. Quirke
  • Patent number: 5286864
    Abstract: The invention relates to new quinuclidines, processes for their preparation and their use as medicaments having cholinomimetic properties.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: February 15, 1994
    Assignee: Boehringer Ingelheim KG
    Inventors: Gerhard Walther, Karl H. Weber, Werner Stransky, Franz J. Kuhn, Enzio Muller, Helmut Ensinger
  • Patent number: 5286736
    Abstract: New pyridyl derivatives of the formula ##STR1## wherein R.sub.1 to R.sub.6, A, X and n are as defined herein, the enantiomers thereof, the cis- and trans-isomers thereof if R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof. The new pyridyl derivatives have antithrombotic activity and thromboxane-mediated activities. The new compounds are also simultaneously thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 -production.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: February 15, 1994
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Rainer Soyka, Wolfgang Eisert, Thomas Mueller, Johannes Weisenberger
  • Patent number: 5270322
    Abstract: Imidazo[1,2-a]pyridines of the formula ##STR1## wherein R.sub.a to R.sub.e are as defined herein, the enantiomers and the salts thereof, which are useful as angiotensin antagonists and for treating conditions treatable with angiotensin antagonists.
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: December 14, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Uwe Ries, Norbert Hauel, Berthold Narr, Jacques van Meel, Wolfgang Wienen, Michael Entzeroth
  • Patent number: 5264573
    Abstract: A process for the preparation of 2-chloro-1,7-dihydropurin-6-one which comprises the steps of:a) suspending 2-thioxanthine in concentrated hydrocloric acid, to produce a suspension; andb) contacting the suspension with chlorine, to produce 2-chloro-1,7-dihydropurin-6-one.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: November 23, 1993
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Reiner Ramert, Albrecht Christmann
  • Patent number: 5248695
    Abstract: The invention relates to the separation of enantiomers, of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: September 28, 1993
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Wolfgang Resemann, Adolf Durr, Gunther Engelhardt, John F. Quirke
  • Patent number: 5242946
    Abstract: A group of known naphthalene derivatives have been found to be useful for preventing or relieving herpes viral infections.
    Type: Grant
    Filed: January 31, 1992
    Date of Patent: September 7, 1993
    Assignee: Bio-Mega, Inc.
    Inventor: Yvan Guindon
  • Patent number: 5232946
    Abstract: The invention relates to new phenylethanolamines of general formula ##STR1## wherein A represents a straight-chained or branched alkylene group,B represents a bond, an alkylene group, a carbonyl or hydroxymethylene group,R.sub.1 represents a hydrogen atom, a halogen atom or a trifluoromethyl group,R.sub.2 represents a hydrogen atom or an amino group,R.sub.3 represents a cyano group, a hydrogen, chlorine or bromine atom andR.sub.4 represents a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group substituted in the end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group,the optical isomers and diastereoisomers and acid addition salts thereof.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: August 3, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Rudolf Hurnaus, Manfred Reiffen, Robert Sauter, Wolfgang Grell, Eckhard Rupprecht
  • Patent number: 5223396
    Abstract: A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation. Also contemplated is a method for the detection of organ transplant or tissue graft rejection.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: June 29, 1993
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Robert Rothlein, Steven D. Marlin
  • Patent number: 5223511
    Abstract: New pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid derivatives which are 5-HT receptor antagonists useful as antiemetic agents and as gastric prokinetic agents of the following formula: ##STR1##wherein R is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; R.sub.1 is hydrogen; R.sub.2 is hydrogen, halogen or C.sub.1-6 alkoxy; Y is oxygen or N--R.sub.3 in which R.sub.3 is hydrogen; A is a group selected from: ##STR2##wherein p is 1; r is 0, 2 or 3: R.sub.4 is hydrogen; R.sub.5 is hydrogen, C.sub.1-6 alkyl, or R.sub.5 is a group of the formula --CR.sub.6 =N--R.sub.7 wherein R.sub.6 is hydrogen, C.sub.1-4 alkyl or amino and R.sub.7 is hydrogen or C.sub.1-6 alkyl; or a pharmaceutically acceptable acid addition salt thereof.The processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions contained in them are also described.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: June 29, 1993
    Assignee: Boehringer Ingelheim Italia S.p.A.
    Inventors: Marco Turconi, Arturo Donetti, Ernesto Montagna, Massimo Nicola, Annamaria Uberti, Rosamaria Micheletti, Antonio Giachetti
  • Patent number: 5212321
    Abstract: A process for producing trimethylene carbonate wherein 1,3-propanediol is reacted with diethylcarbonate in the presence of zinc powder, zinc oxide, tin powder, tin halide or an organo-tin compound, at an elevated temperature.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: May 18, 1993
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Klaus R. Muller, Berthold Buchholz, Joachim Hess
  • Patent number: 5212157
    Abstract: Disclosed herein are peptide derivatives which inhibit the activity of human immunodeficiency virus (HIV) protease. The peptide derivatives can be represented by general formula R.sup.1 --R.sup.2 --Y--R.sup.3 --R.sup.4 wherein R.sup.1 is an optionally substituted 3-(1,2,3,4-tetrahydroisoquinolyl)carbonyl residue, R.sup.2 and R.sup.3 are amino acid or analogous amino acid residues (R.sup.3 may optionally be absent), Y is a non-peptide linking unit, e.g. statyl, and R.sup.4 is [--NR.sup.17 CH(R.sup.18)C(O)].sub.p --Z wherein R.sup.17 is hydrogen or lower alkyl, R.sup.18 is an amino acid or analogous amino acid side chain, p is zero or 1 and Z is a terminal group (e.g. hydroxy or amino), or R.sup.4 is --NR.sup.17 CR.sup.18 (R.sup.21)CH.sub.2 --OH wherein R.sup.17 and R.sup.18 are as noted hereinabove and R.sup.21 is hydrogen, lower alkyl or hydroxy(lower)alkyl. The derivatives also inhibit renin activity.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: May 18, 1993
    Assignee: Bio-Mega, Inc.
    Inventors: Paul C. Anderson, Yvan Guindon, Christiane Yoakim
  • Patent number: 5200522
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 6, 1993
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Patent number: 5198425
    Abstract: Disclosed herein are peptides of the formulaY--R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4 --R.sup.5 --R.sup.6 --R.sup.7 --R.sup.8 --R.sup.9 --Zwherein R.sup.1 to R.sup.9 are designated amino acid residues; Y is hydrogen or lower alkanoyl, or Y is the hexapeptide radical W-lle-R.sup.10 -Ser-R.sup.11 -Val-R.sup.12 wherein W is hydrogen or lower alkanoyl and R.sup.10, R.sup.11 and R.sup.12 are designated amino acid residues, or Y is a fragment of the hexapeptide radical wherein from one to five of the amino acid residues (i.e. Ile to Val) may be deleted serially from the amino terminus of the hexapeptide radical; and Z is hydroxy, amino, lower alkylamino or di(lower alkyl)amino. The peptides inhibit bacterial ribonucleotide reductase and are indicated for preventing or ameliorating bacterial infections.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: March 30, 1993
    Assignee: Bio-Mega, Inc.
    Inventors: Sumanas Rakhit, Raymond Plante, Gregory P. Cosentino