Patents Represented by Attorney David J. Levy
  • Patent number: 5438132
    Abstract: A process for removing osmium from an aqueous solution of nucleosides comprising adding hydrogen sulfide, an aromatic pi base such as pyridine, and a mineral acid. The osmium is precipitated out of solution.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: August 1, 1995
    Assignee: Glaxo Group Limited
    Inventors: Brian L. Bray, Maynard E. Lichty, John J. Partridge, John P. Turnbull
  • Patent number: 5380872
    Abstract: CCK modulators, e.g. agonists or antagonists, of the following formula (I): ##STR1## or a base-addtion salt thereof.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: January 10, 1995
    Assignee: Glaxo Inc.
    Inventors: Elizabeth E. Sugg, Milana Dezube, Gavin C. Hirst
  • Patent number: 5318183
    Abstract: A bottle having an inserted tube in its neck to effectively reduce its interior volume and allow a large surface area for the bottle exterior, e.g. for supporting a large label or to allow oversized print, with a relatively small interior volume, e.g. to prevent abrasions caused by the interior contents moving excessively against each other.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: June 7, 1994
    Assignee: Glaxo, Inc.
    Inventors: Donald B. Cohen, Norris W. Matthews
  • Patent number: 5258519
    Abstract: Compounds of the following formula (I): ##STR1## where R.sup.1 and R.sup.2 are alkyl or cycloalkyl, which may be substituted, R.sup.4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: November 2, 1993
    Assignee: Glaxo Inc.
    Inventors: Thomas N. Wheeler, Terrence P. Kenakin
  • Patent number: 5252560
    Abstract: Compounds are described of the formula ##STR1## wherein: R.sup.1 is C.sub.3-6 alkyl or C.sub.1-3 alkylthioC.sub.1-3 alkyl;R.sup.2 is an optionally substituted C.sub.1-6 alkyl or C.sub.1-6 alkoxy group, aryl, heteroaryl, arylC.sub.1-4 alkyl, heteroarylC.sub.1-4 alkyl or a side-chain of a natural .alpha.-amino acid;R.sup.3 is hydrogen, C.sub.1-6 alkyl, CHR.sup.4 COR.sup.5 (where R.sup.4 is a side-chain of a natural .alpha.-amino acid and R.sup.5 is hydroxyl, C.sub.1-6 alkoxy or NHR.sup.6 where R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group) or a group (CH.sub.2).sub.n X (where n is 1 to 6 and X is hydroxyl, C.sub.1-4 alkoxy, heteroaryl or a group NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are each hydrogen or C.sub.1-6 alkyl or the group NR.sup.7 R.sup.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: October 12, 1993
    Assignee: Glaxo Inc.
    Inventors: Peter L. Myers, Andrew B. McElroy, Michael Gregson, Peter J. Brown, Howard G. Davies, David H. Drewry, Michael A. Foley
  • Patent number: 5233041
    Abstract: Synthesis of the triol of formula (I) or its amine-protected derivative from a cyclopentene of the formula (II) or its amine-protected derivative: ##STR1## via steps including oxidation to the aldehyde, migration of the double bond, reduction of the aldehyde moiety back to the alcohol grouping and 1,2-cis-dihydroxylation of the double bond.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: August 3, 1993
    Assignee: Glaxo Group Limited
    Inventors: Brian L. Bray, Maynard E. Lichty, John J. Partridge, John P. Turnbull
  • Patent number: 5204463
    Abstract: Pyridazinones of the following formula (I): ##STR1## where R.sup.1 -R.sup.4 are a variety of substituents and L is a linking group, a pharmaceutical composition for treating congestive heart failure, novel intermediates, methods for such treatment and processes for preparing compounds of formula (I).
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: April 20, 1993
    Assignee: Glaxo Inc.
    Inventors: Thomas N. Wheeler, Terrence P. Kenakin, Joel E. Shaffer
  • Patent number: 5192757
    Abstract: Cobalt prophyrins of the following formula (l): ##STR1## or a salt or ligand complex thereof and their synthesis, pharmaceutical compositions and use in controlling obesity.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: March 9, 1993
    Assignee: Glaxo Inc.
    Inventors: Michael R. Johnson, Stephen V. Frye
  • Patent number: 5187368
    Abstract: A method for detecting the presence or absence of microorganisms in a liquid test sample is provided without need for withdrawing an aliquot or destroying the sample. The method comprises taking near-infrared spectra of the sample and comparing it visually or mathematically to the spectra of a standard, which may be the values of the spectra known to the operator or may be a standard sample that is provided and run side-by-side.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: February 16, 1993
    Assignees: Glaxo Inc., The University of Kentucky
    Inventors: Leonard J. Galante, Robert A. Lodder
  • Patent number: 5174475
    Abstract: A sequential dosing medicament for topical treatment of fungal infections comprising a first pharmaceutical composition having an antifungal agent and an antiinflammatory agent, e.g. a steroid, a second separate pharmaceutical composition having only an antifungal agent as the active ingtredient. Also a method for such sequential dosing, particularly using oxiconazole as the antifungal agent and fluticasone as the steroid.
    Type: Grant
    Filed: March 26, 1991
    Date of Patent: December 29, 1992
    Assignee: Glaxo Inc.
    Inventors: Robert M. Day, Charles E. Holland, George E. Van Lear
  • Patent number: 5153209
    Abstract: Pyridones of formula (I) for treating congestive heart failure: ##STR1## wherein: R.sup.1 and R.sup.2 are a variety of phenyl substituents, L is a divalent alkylene linking group. Pharmaceutical composition, methods for their use in treating cardiovascular conditions, processes used in synthesis and intermediates used in such processes.
    Type: Grant
    Filed: June 13, 1991
    Date of Patent: October 6, 1992
    Assignee: Glaxo Inc.
    Inventors: Thomas N. Wheeler, Terrence P. Kenakin, Joel E. Shaffer
  • Patent number: 5149697
    Abstract: Pharmaceutical compositions containing cobalt porphyrins of the following formula (I): ##STR1## wherein R.sup.1 =--CH.sub.2 CH.sub.2 CN and R.sup.2 =--CH.sub.2 CH.sub.2 COOH or R.sup.1 and R.sup.2 =--CH.sub.2 CH.sub.2 COOH or R.sup.1 =--H and R.sup.2 =--CH.sub.2 lCH.sub.2 COOH or a salt or ligand complex thereof and their use in controlling obesity.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: September 22, 1992
    Assignee: Glaxo Inc.
    Inventors: Michael R. Johnson, Stephen V. Frye
  • Patent number: 5136085
    Abstract: Process for synthesizing 2-aminobenzophenones such as the following formula (I): ##STR1## wherein X.sup.1 and X.sup.2 are substituents and r and s are 1 or 2, by reacting an anthranilic acid amide e.g. an N-alkoxy-N-alkyl anthranilic acid amide, with a halobenzene in the presence of an alkyllithium reagent.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: August 4, 1992
    Assignee: Glaxo Inc.
    Inventors: Marty C. Johnson, Stephen V. Frye
  • Patent number: 5100892
    Abstract: Compounds of the following formula (I): ##STR1## where R.sup.1 and R.sup.2 are alkyl or cycloalkyl, which may be substituted, R.sup.4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: March 31, 1992
    Assignee: Glaxo Inc.
    Inventors: Thomas N. Wheeler, Terrence P. Kenakin
  • Patent number: 5096904
    Abstract: Pyridazinones of the following formula (I): ##STR1## where R.sup.1 -R.sup.4 are a variety of substituents and L is a linking group, a pharmaceutical composition for treating congestive heart failure, novel intermediates, methods for such treatment and processes for preparing compounds of formula (I).
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: March 17, 1992
    Assignee: Glaxo Inc.
    Inventors: Thomas N. Wheeler, Terrence P. Kenakin, Joel E. Shaffer
  • Patent number: 5053543
    Abstract: Process for synthesizing 2-aminobenzophenones such as the following formula (I): ##STR1## wherein X.sup.1 and X.sup.2 are substituents and r and s are 1 or 2, by reacting an anthranilic acid amide e.g. an N-alkoxy-N-alkyl anthranilic acid amide, with a halobenzene in the presence of an alkyllithium reagent.
    Type: Grant
    Filed: November 28, 1990
    Date of Patent: October 1, 1991
    Assignee: Glaxo Inc.
    Inventors: Marty C. Johnson, Stephen V. Frye
  • Patent number: 5053338
    Abstract: A kinetic resolution of pyridazinones of the following formula (A): ##STR1## where R.sup.1 is alkyl by enzymatic hydrolysis results in good optical purity of the phenolic product. This is significant considering the distance in the molecule (A) from the C-5 chiral center to the site of hydrolysis.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: October 1, 1991
    Assignee: Glaxo Inc.
    Inventors: Brian L. Bray, John J. Partridge
  • Patent number: 5051431
    Abstract: Pyridones of formula (I) for treating congestive heart failure: ##STR1## wherein: R.sup.1 and R.sup.2 are a variety of phenyl substituents, L is a divalent alkylene or amide containing alkylene linking group. Pharmaceutical composition, methods for their use in treating cardiovascular conditions, processes used in synthesis and intermediates used in such processes.
    Type: Grant
    Filed: August 9, 1990
    Date of Patent: September 24, 1991
    Assignee: Glaxo Inc.
    Inventors: Thomas N. Wheeler, Terrence P. Kenakin, Joel E. Shaffer
  • Patent number: 4851094
    Abstract: An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): ##STR1## with H.sub.2 O.sub.2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
    Type: Grant
    Filed: July 20, 1987
    Date of Patent: July 25, 1989
    Assignee: McNeilab, Inc.
    Inventors: Cynthia A. Maryanoff, James N. Plampin, Robin C. Stanzione
  • Patent number: 4837328
    Abstract: A diastereoselective process for known antidepressive compounds (I) via reduction of the corresponding alcohol (VII): ##STR1## whereby the product mixture of diastereomers is surprisingly and unexpectedly rich in the content of the trans configuration (II) over the cis configuration (III) as defined in the following formulae: ##STR2## The preferred reaction conditions include use of a borane complex as the reducing agent and an acidic solvent such as trifluoroacetic acid.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: June 6, 1989
    Assignee: McNeilab, Inc.
    Inventors: Bruce E. Maryanoff, Cynthia A. Maryanoff, David F. McComsey, Kirk L. Sorgi