Abstract: New syn-isomers of 3-cephem-4-carboxylic acids having anti-bacterial activities, processes for preparation thereof, pharmaceutical compositions thereof, with the acids being substituted at the 3 position with acyloxymethyl, hydroxymethyl, formyl or heterocyclic thiomethyl groups and at the 7 position with alkoxyiminoacetamido substituted with substituted phenyl or substituted thiazolyl.
Abstract: A process for preparing an azetidinone of the formula: ##STR1## which comprises reacting a C-unsubstituted methyleneamine of the formula: ##STR2## with R.sup.2 --CH.sub.2 COOH, its acid halide or anhydride, in the presence of boron trihalide and an organic base, wherein R.sup.1 is an organic residue bearing a carboxy group or its derivative and R.sup.2 is azido, substituted amino, halogen, acyloxy, alkoxy, aryloxy or aralkoxy.
Abstract: Belt mountable cartridge pouch for fast convenient release of cartridges, wherein cartridge pockets are formed by merely placing slots in the original pouch blank, and folding the blank along the longitudinal axis of said slot to form and mold the pockets.
Abstract: 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.
Abstract: 7-(2-Hydroxyimino-2-hydroxyphenyl-acetamido)-3-substituted-3-cephem-4-carbo xylic acids are disclosed which possess an antibacterial activity.
Abstract: 3-Substituted-7-substituted alkanamido-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities, processes for the preparation thereof, pharmaceutical compositions comprising the same, and methods of using the same therapeutically in the treatment of infections.
Abstract: A dosage composition of corticosteroids with calcium and optionally vitamins B12, C and/or D for treatment of arthritis and other rheumatic disease.
Abstract: Substituted phenylacetic acid compounds represented by the following general formula and preparation thereof: ##STR1## wherein R.sup.1 is hydrogen or protected carboxy,R.sup.2 is hydrogen, or protected amino, provided that when R.sup.1 is hydrogen, then R.sup.2 is protected amino, and when R.sup.2 is hydrogen, then R.sup.1 is protected carboxy,R.sup.3 is oxo, hydroxyimino or protected hydroxyimino,R.sup.4 is hydrogen or halogen, andm is an integer of 1 to 3.
Abstract: R.sup.2 is an aliphatic hydrocarbon residue which may be substituted with hydroxy, protected hydroxy or lower alkylthio,R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)alkyl or hydroxy(lower)alkyl, andR.sup.4 is carboxy or functionally modified carboxy, "syn" or "anti" isomer.
Abstract: Bicyclomycin derivatives having the general formula: ##STR1## wherein R.sub.I is ##STR2## R.sub.II and R.sub.III are hydrogens or aliphatic, R.sub.
Abstract: The present invention relates to new substituted-phenyl substituted-alkyl ethers and pharmaceutically acceptable salts thereof, which have hypolipidemic activity, and to processes for the preparation thereof, the compound having the following formula ##STR1## wherein R.sub.1 is lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR2## wherein R.sub.3 and R.sub.4 are each hydrogen or lower alkyl,R.sub.5 is carboxy, esterified carboxy or hydroxymethyl and A is lower alkylene;R.sub.2 is hydrogen, lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR3## and R.sub.6 is hydrogen, hydroxy or lower alkoxy; in which the aryl or the ar(lower)alkyl for R.sub.1 and R.sub.2 may be substituted with halogen, hydroxy or lower alkoxy, and when R.sub.1 and R.sub.2 are both lower alkyl, R.sub.1 and R.sub.2 may be linked together.
Abstract: Extraction of purified plant anthocyanin colors particularly from dark grapes by treating impure materials to insure discrete monomeric anthocyanin molecules in solution and then passing the solution through ultrafiltration membranes to retain soluble and/or cloudy macromolecular, e.g., colloidal, impurities upstream that produce, an aging, haze and sediments, and pass the monomeric anthocyanins downstream for further concentration as liquid or powder to give a stable color concentrate that can be used as a color additive. For example, fruit solids may be treated with sulfur dioxide solutions to ionize, decolor and insure the monomeric state of the pigment molecules (change from anthocyanins to chromon 2-and 4-sulfonates), ultrafiltering the solution to pass the anthocyanins downstream while retaining upstream the macromolecular components such as pectins, tannins, proteins, complexes thereof, etc.
Abstract: A new animal feed composition which comprises bicyclomycin and a new method for promoting the growth of animals, which comprises oral administration of the same to animals.
Abstract: New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 is amino or acylamino, and A is selected from a variety of groups.
Abstract: Cephalosporanic acid derivatives and preparation thereof having the following formula ##STR1## wherein R.sub.1 is hydrogen or acyl, and R.sub.2 is aminoalkyl-, acylaminoalkyl-, sulfoalkylaminoalkyl-, or hydroxyalkyl-substituted, N- or N and S-containing heterocyclic groups.
Abstract: 7-[.beta.-Aminoacylamino]-3-substituted-3-cephem-4-carboxylic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkenyl, aryl or a heterocyclic group,R.sub.2 is hydrogen or lower alkyl, orR.sub.1 and R.sub.2 mean, taken together with the adjacent carbon atoms, cycloalkyl or cycloalkenyl,R.sub.3 is hydrogen, lower alkylthio or a hetero cyclic-thio group, andM is hydrogen or a nontoxic, pharmaceutically acceptable cation,processes for the preparation of the same and composition thereof. These compounds are useful as antibacterial agents.
Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammal including human being and animals.
Abstract: This invention is concerned with 7-(.alpha.-substituted glycinamido)-3-substituted methyl-3-cephem-4-carboxylic acids, derivatives and non-toxic pharmaceutical salts thereof, which possess antibacterial activity, process for preparation thereof, having the following general formula ##STR1## wherein R.sub.1, R.sub.2, and M are as defined hereinafter and particularly where R.sub.3 is hydrogen, lower alkanoyloxy or a pyridinium group.