Patents Represented by Attorney Dayton R. Stemple
  • Patent number: 4279818
    Abstract: New syn-isomers of 3-cephem-4-carboxylic acids having anti-bacterial activities, processes for preparation thereof, pharmaceutical compositions thereof, with the acids being substituted at the 3 position with acyloxymethyl, hydroxymethyl, formyl or heterocyclic thiomethyl groups and at the 7 position with alkoxyiminoacetamido substituted with substituted phenyl or substituted thiazolyl.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: July 21, 1981
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Takashi Masugi, Hisashi Takasugi, Hiromu Kochi
  • Patent number: 4264498
    Abstract: A process for preparing an azetidinone of the formula: ##STR1## which comprises reacting a C-unsubstituted methyleneamine of the formula: ##STR2## with R.sup.2 --CH.sub.2 COOH, its acid halide or anhydride, in the presence of boron trihalide and an organic base, wherein R.sup.1 is an organic residue bearing a carboxy group or its derivative and R.sup.2 is azido, substituted amino, halogen, acyloxy, alkoxy, aryloxy or aralkoxy.
    Type: Grant
    Filed: February 21, 1979
    Date of Patent: April 28, 1981
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
  • Patent number: 4262833
    Abstract: Belt mountable cartridge pouch for fast convenient release of cartridges, wherein cartridge pockets are formed by merely placing slots in the original pouch blank, and folding the blank along the longitudinal axis of said slot to form and mold the pockets.
    Type: Grant
    Filed: February 11, 1980
    Date of Patent: April 21, 1981
    Inventor: Eugene DeSantis
  • Patent number: 4263291
    Abstract: 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.
    Type: Grant
    Filed: April 3, 1979
    Date of Patent: April 21, 1981
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Hisashi Takasugi, Toshiyuki Chiba, Zenzaburo Tozuka
  • Patent number: 4254117
    Abstract: 7-(2-Hydroxyimino-2-hydroxyphenyl-acetamido)-3-substituted-3-cephem-4-carbo xylic acids are disclosed which possess an antibacterial activity.
    Type: Grant
    Filed: December 20, 1978
    Date of Patent: March 3, 1981
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Takashi Masugi, Hisashi Takasugi, Hiromu Kochi
  • Patent number: 4254260
    Abstract: 3-Substituted-7-substituted alkanamido-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities, processes for the preparation thereof, pharmaceutical compositions comprising the same, and methods of using the same therapeutically in the treatment of infections.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: March 3, 1981
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Takashi Masugi, Hisashi Takasugi, Hiromu Kochi
  • Patent number: 4252952
    Abstract: This invention is concerned with 7-(.alpha.
    Type: Grant
    Filed: June 28, 1979
    Date of Patent: February 24, 1981
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tadayoshi Takano, Susumu Horibe
  • Patent number: 4252797
    Abstract: A dosage composition of corticosteroids with calcium and optionally vitamins B12, C and/or D for treatment of arthritis and other rheumatic disease.
    Type: Grant
    Filed: July 19, 1979
    Date of Patent: February 24, 1981
    Inventor: Walter Rosenthal
  • Patent number: 4237305
    Abstract: Substituted phenylacetic acid compounds represented by the following general formula and preparation thereof: ##STR1## wherein R.sup.1 is hydrogen or protected carboxy,R.sup.2 is hydrogen, or protected amino, provided that when R.sup.1 is hydrogen, then R.sup.2 is protected amino, and when R.sup.2 is hydrogen, then R.sup.1 is protected carboxy,R.sup.3 is oxo, hydroxyimino or protected hydroxyimino,R.sup.4 is hydrogen or halogen, andm is an integer of 1 to 3.
    Type: Grant
    Filed: March 30, 1977
    Date of Patent: December 2, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Hidekazu Takeno
  • Patent number: 4220761
    Abstract: R.sup.2 is an aliphatic hydrocarbon residue which may be substituted with hydroxy, protected hydroxy or lower alkylthio,R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)alkyl or hydroxy(lower)alkyl, andR.sup.4 is carboxy or functionally modified carboxy, "syn" or "anti" isomer.
    Type: Grant
    Filed: September 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Takashi Masugi, Hisashi Takasugi, Hiromu Kochi
  • Patent number: 4215043
    Abstract: Bicyclomycin derivatives having the general formula: ##STR1## wherein R.sub.I is ##STR2## R.sub.II and R.sub.III are hydrogens or aliphatic, R.sub.
    Type: Grant
    Filed: October 15, 1976
    Date of Patent: July 29, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Shizuo Maeno, Yoshihiko Kitaura
  • Patent number: 4214094
    Abstract: The present invention relates to new substituted-phenyl substituted-alkyl ethers and pharmaceutically acceptable salts thereof, which have hypolipidemic activity, and to processes for the preparation thereof, the compound having the following formula ##STR1## wherein R.sub.1 is lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR2## wherein R.sub.3 and R.sub.4 are each hydrogen or lower alkyl,R.sub.5 is carboxy, esterified carboxy or hydroxymethyl and A is lower alkylene;R.sub.2 is hydrogen, lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR3## and R.sub.6 is hydrogen, hydroxy or lower alkoxy; in which the aryl or the ar(lower)alkyl for R.sub.1 and R.sub.2 may be substituted with halogen, hydroxy or lower alkoxy, and when R.sub.1 and R.sub.2 are both lower alkyl, R.sub.1 and R.sub.2 may be linked together.
    Type: Grant
    Filed: March 30, 1977
    Date of Patent: July 22, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Yoshihisa Saito
  • Patent number: 4211577
    Abstract: Extraction of purified plant anthocyanin colors particularly from dark grapes by treating impure materials to insure discrete monomeric anthocyanin molecules in solution and then passing the solution through ultrafiltration membranes to retain soluble and/or cloudy macromolecular, e.g., colloidal, impurities upstream that produce, an aging, haze and sediments, and pass the monomeric anthocyanins downstream for further concentration as liquid or powder to give a stable color concentrate that can be used as a color additive. For example, fruit solids may be treated with sulfur dioxide solutions to ionize, decolor and insure the monomeric state of the pigment molecules (change from anthocyanins to chromon 2-and 4-sulfonates), ultrafiltering the solution to pass the anthocyanins downstream while retaining upstream the macromolecular components such as pectins, tannins, proteins, complexes thereof, etc.
    Type: Grant
    Filed: September 13, 1977
    Date of Patent: July 8, 1980
    Assignee: Welch Foods Inc.
    Inventor: Bruce K. Wallin
  • Patent number: 4209518
    Abstract: A new animal feed composition which comprises bicyclomycin and a new method for promoting the growth of animals, which comprises oral administration of the same to animals.
    Type: Grant
    Filed: September 14, 1978
    Date of Patent: June 24, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazumasa Mine, Takeo Oshima
  • Patent number: 4207234
    Abstract: New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 is amino or acylamino, and A is selected from a variety of groups.
    Type: Grant
    Filed: December 7, 1977
    Date of Patent: June 10, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Yoshihisa Saito, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Youichi Shiokawa, Takao Takaya, Tadaaki Komori, Tsutomu Teraji, Keiji Hemmi, Hisashi Takasugi
  • Patent number: 4205166
    Abstract: Cephalosporanic acid derivatives and preparation thereof having the following formula ##STR1## wherein R.sub.1 is hydrogen or acyl, and R.sub.2 is aminoalkyl-, acylaminoalkyl-, sulfoalkylaminoalkyl-, or hydroxyalkyl-substituted, N- or N and S-containing heterocyclic groups.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: May 27, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Kunihiko Tanaka, Tsutomu Teraji, Keiji Hemmi
  • Patent number: 4187374
    Abstract: 7-[.beta.-Aminoacylamino]-3-substituted-3-cephem-4-carboxylic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkenyl, aryl or a heterocyclic group,R.sub.2 is hydrogen or lower alkyl, orR.sub.1 and R.sub.2 mean, taken together with the adjacent carbon atoms, cycloalkyl or cycloalkenyl,R.sub.3 is hydrogen, lower alkylthio or a hetero cyclic-thio group, andM is hydrogen or a nontoxic, pharmaceutically acceptable cation,processes for the preparation of the same and composition thereof. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: February 5, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kunihiko Tanaka, Masaru Kurita, Osamu Nishiwaki
  • Patent number: 4181800
    Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammal including human being and animals.
    Type: Grant
    Filed: October 6, 1976
    Date of Patent: January 1, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
  • Patent number: 4178445
    Abstract: This invention is concerned with 7-(.alpha.-substituted glycinamido)-3-substituted methyl-3-cephem-4-carboxylic acids, derivatives and non-toxic pharmaceutical salts thereof, which possess antibacterial activity, process for preparation thereof, having the following general formula ##STR1## wherein R.sub.1, R.sub.2, and M are as defined hereinafter and particularly where R.sub.3 is hydrogen, lower alkanoyloxy or a pyridinium group.
    Type: Grant
    Filed: May 13, 1977
    Date of Patent: December 11, 1979
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tadayoshi Takano, Susumu Horibe
  • Patent number: D254124
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: February 5, 1980
    Inventor: Martin L. Greenfield