Abstract: New cephalosporin compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy, R.sub.2 is a substituted alkanoyl group, R.sub.3 is hydrogen, carbamoyloxy, alkanoyloxy or a heterocyclic-thio group which may have suitable substituents, and R.sub.4 is carboxy or protected carboxy.

Abstract: An indoor golf driving range within a pressurized tent cover having a target backstop in the center with a driving range on each side with a system for collecting and returning balls to a specific point for reuse. The target is positioned and marked to show if the ball hitting the target has the proper loft with the particular hitting club used. The target backstop may be electrically wired to indicate by lights where it is contacted by a driven golf ball.

Abstract: The present invention relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antibacterial activities and to processes for the preparation thereof, to pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in human beings and animals.

Abstract: A bundle of Margach ingots being self-skidded on platform ingots having legs at each end that provide for insertion of a lift fork between the legs and below the main body of the ingots, said body intermediate its end being weakened at some point for easy breaking into two half ingots, said ends being provided with notches or other means to feed each half ingot on a chain feeder into a molten bath. The bundles must be tied with wire (rather than conventional straps) to fit tightly into the notches on first applying same to avoid later slippage into the notch at a critical time.

Abstract: This invention relates to new compounds having antibacterial activity.More particularly, it relates to new antibiotics, Nocardicin E and F and to a process for production of the same by fermentation.

Abstract: This invention relates to 1,4-dihydropyridine derivatives. More particularly, it relates to new 1,4-dihydropyridine derivatives thereof which have vasodilating and anti-hypertensive activity, to processes for the preparation thereof, and to pharmaceutical composition comprising the same for therapeutical treatment in cardiovascular diseases and hypertension in human being.

Abstract: A process for the isolation and purification of cephalosporin from a solution containing impurities which includes treating the solution with macroporous non-ionic adsorption resin to adsorb the cephalosporin thereto and then eluting the cephalosporin from the resin with an aqueous solution of anionic surface active agent.

Abstract: The new 7-(.alpha.,.alpha.-disubstituted-acetamido)-3-substituted-3-cephem-4-carbo xylic acid of the present invention is represented by the following formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, hydroxy, nitro, lower alkoxy or acylamino, R.sup.2 is hydrogen or acyl andR.sup.3 is lower alkanoyloxy, carbamoyloxy which may have lower alkyl, aryl or protective group for amino, or a heterocyclicthio which may have lower alkyl, aryl or protective group for amino, or a hetero- which may have lower alkyl.

Abstract: Purification of Fr-1923 antibiotic substance by treatment with a macroporous non-ionic adsorption resin such as styrene-divinyl benzene copolymer or acrylic ester polymer.

Abstract: An elongated cylinder having a hollow interior is provided with a first open end and a second closed end. Reflecting media are provided on the interior portion of the closed end and on half of the inner surface of the circumferential wall surface of the cylinder. First and second scales are provided on the other half of the wall surface, each being translucent in part so that incident light directed into the interior of the elongated cylinder will pass therethrough. The gloss of a surface may be measured by placing the closed end of the elongated cylinder on the surface and directing an incident light into the hollow interior via the first open end, and noting the reflection of the scales in the surface being measured. The glossier the surface, the more of the scales that will be reflected.

Abstract: A method and composition for removal of undesirable materials such as poisons from the gastrointestinal tract including the ingestion of a mixture of sorbitol and activated carbon whereby the activated carbon adsorbs the undesired material and carries it through the digestive tract, accelerated by the laxative action of sorbitol.

Abstract: Mixtures of at least two water-insoluble monoazo dyestuffs of the formula: ##STR1## wherein D is the residue of a diazo component of the benzene series free from sulphonic acid and carboxyl groups which may be substituted with one or more optionally substituted alkyl, alkoxy, alkoxyalkyl, acyloxy, alkylcarbonyl and/or alkoxycarbonyl groups and/or one halogen atom, R is hydrogen, halogen or an optionally substituted alkoxy group and A is an aromatic radical which may be substituted with one or two optionally substituted alkyl and/or alkoxy groups and/or one halogen atom, can be used for the coloration of textile materials consisting at least partly of linear, aromatic polyesters. The melting points of these mixtures are lower than those of their individual dyestuff components, preferably lower than 200.degree. or 180.degree. C.

Abstract: A prophylactic, therapeutic or hygienical agent effective for preventing or treating various virus diseases in fish, comprising at least one enediol compound or a salt thereof (e.g. ascorbic acid, erythorbic acid, or a salt thereof with an inorganic or organic base) in a combination with a heavy metal, preferably in the form of a water-soluble salt thereof (e.g. copper sulfate), and the use of the active agent for preventing or treating the virus diseases in fish by administering the active agent to the fish orally or parenterally or by bathing, washing or breeding the fish in an aqueous solution containing the active agent.

Abstract: Nocardicin A is produced by culturing a Nocardicin A producing microorganism in a medium containing at least one of shikimic acid, a hydroxy phenyl carboxylic acid, glycine, alanine, serine, homoserine, .alpha.aminobutyric acid, .alpha., .beta.-diaminoproprionic acid and their ester, acid amide and hydrazide derivatives in a concentration of 2-0.001% by weight.

Abstract: The process for preparation of and the intermediate compounds such as 1H-tetrazole-5-thiol having the formula ##STR1## wherein R.sub.1 is alkyl, aminoalkyl, acylaminoalkyl, aryl, alkoxycarbonylaminoalkyl, halogen-substituted aryl or alkylamino-substituted aryl and R.sub.2 is hydrogen or arakyl, preferably benzyl. The compound is produced by reacting a substituted thiosemicarbazide with an aralkyl chloride, subjecting the resultant compound to diazotization, and reacting the resultant compound with a Friedel Crafts catalyst. Optionally, this may be further hydrolyzed when R.sub.1 is aminoalkyl and/or converted to conventional salts.

Abstract: 7-[.beta.-Aminoacylamino]-3-substituted-3-cephem-4-carboxylic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkenyl, aryl or a heterocyclic group,R.sub.2 is hydrogen or lower alkyl, orR.sub.1 and R.sub.2 mean, taken together with the adjacent carbon atom, cycloalkyl or cycloalkenyl,R.sub.3 is hydrogen, lower alkylthio or a hetero cyclic-thio group, andM is hydrogen or a nontoxic, pharmaceutically acceptable cation,Processes for the preparation of the same and composition thereof. These compounds are useful as antibacterial agents.

Abstract: 2-substituted thio-1,4-benzodiazepine derivatives having medicinal use of the general formula ##STR1## wherein R.sub.1 and R.sub.2 individually signify hydrogen atom or a halogen atom, or a nitro, amino, hydroxy, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, alkanoylamino or dialkylamino group, R.sub.3 signifies an alkylene group, and R.sub.4 and R.sub.5 individually signify hydrogen atom or an alkyl group and, when R.sub.4 and R.sub.5 are both alkyl groups, said alkyl groups together may form a ring with or without oxygen atom or an imino group, said ring optionally having a substituent or substituents, and its non-toxic pharmaceutically acceptable salts.

Abstract: Antibacterial synergistic mixture of Nocardicin A and cycloserine or their respective pharmaceutically acceptable salts.

Abstract: This invention relates to cephalosporanic acid derivatives of the formula: ##STR1## where R.sub.1 is phenyl or thienyl,R.sub.2 is pyridyl andR.sub.3 is hydrogen or alkylthio, and pharmaceutically aceptable salts thereof, which possess antibacterial activity, pharmactical compositions of the same and processes for the preparation thereof.

Abstract: Compounds of the formula ##STR1## and its salts, wherein A is lower alkylene, and R is optionally acyl or lower alkoxy carbonyl substituted amino or optionally acyl substituted hydroxy. The compounds are useful as intermediates in making cephalosporin derivatives.