Abstract: Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.

Abstract: The method comprises the stages of the curtain coating of a first aqueous film-forming composition on a substrate; and the curtain coating of a second aqueous film-forming composition on said metallized substrate, characterized in that said first and second aqueous film-forming composition comprises a first emulsion polymer and/or a second colloidal dispersion polymer.

Abstract: Anionically substituted 7-nitroindoline derivatives are disclosed and their uses as caged compounds from which effector species such as neurotransmitters and amino acids are releasable on irradiation with light.

Abstract: A conveyor assembly is provided, which includes a link belt formed of a plurality of overlapping belt links. A plurality of engagement elements are attached to the link belt to form an upper surface. In one embodiment, the link belt includes a plurality of apertures and the engagement elements comprises connectors that cooperate with the apertures to connect the engagement elements to the link belt. The upper surface of the engagement elements may be configured in a variety of forms. In one embodiment, the engagement elements comprise a protuberance that projects upwardly to form a point of limited contact.

Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either electric current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to electrokinetically inducing fluid flow to confine a selected material in a region of a microchannel that is not influenced by an electric field. Other structures for inducing fluid flow in accordance with this invention include nanochannel bridging membranes and alternating current fluid pumping devices. Applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.

Abstract: The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition.

Abstract: The invention describes a process for filter selection of anti-angiogenesis antibody fragments from a large combinatorial repertoire; the invention further relates to the anti-angiogenesis antibody fragments thus obtained.

Abstract: The present invention relates to the fields of molecular biology and plant biology. Specifically, the invention is directed to the methods for expressing spider silk proteins in plants and the synthesis and purification of spider silk proteins therefrom.

Abstract: Materials and methods for identifying agents which modulate KSR mediated signal transduction are provided.

Abstract: An automobile seat in which spaced apart side brackets of a seat back are individually faced to spaced apart side brackets of a seat cushion, a pivot shaft is penetrated through the brackets and bridged between the brackets, and reclining lock devices are assembled on the axis of the pivot shaft to the side brackets, whereby the seat back is held upright such that the angle of the seat back relative to the seat cushion is adjustable and that the seat back is reclinable forward and rearward, and in which the seat back is urged by return spring members to the upright direction. The spring members comprise first and second torsion bar springs that are arranged in proximity to the pivot shaft. The springs are engaged at both end portions thereof with corresponding side brackets in such a manner that the springs cross each other.

Abstract: An apparatus and method are provided to rapidly thaw and heat frozen bags of biological materials, such as plasma. The apparatus has a hollow bladder having a flexible wall that is placed in contact with the bag. A circulation system draws fluid from a reservoir and fills the bladder with the fluid. The circulation system also drains fluid from the bladder. A heater in the reservoir heats the fluid before the fluid enters the bladder. As heated fluid flows through the bladder, heat is transferred through the bladder wall to the plasma bag to thaw the biological material. The bladder wall expands against the plasma bag as the bladder fills with fluid, and contracts from the plasma bag as the bladder is drained. The expansion and contraction of the bladder wall agitates the plasma bag and biological material to accelerate the thawing process.

Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.

Abstract: A clamping arrangement may comprise a support having a base and an extension, a clamping member having a body, a clamping edge and one or more engaging features for engaging the support extension. The body may have a hole in which a fastener may be disposed when the clamping member engages the extension of the support. A stud and nut or a bolt may provide the fastener for moving the clamping member for applying a clamping force. The body may have an opening for engaging the extension of the support when the clamping member is in a certain position.

Abstract: A trampoline has an enclosure system including a barrier of a flexible material (14) such as a net material surrounding the trampoline mat above the mat and having a lower peripheral part coupled directly or indirectly to the mat, and a plurality of resiliently flexible generally upright enclosure support members or rods (13) which are retained at or towards the lower ends of the enclosure support members and below the mat (1) by the frame (4) of the trampoline and which support the net above the mat, so that the enclosure is free to deform away from the mat when impacted by a user against an enclosure support member and/or against said barrier of flexible material.

Abstract: A transgenic non-human animal with a homologous disruption of the KSR-2 gene is disclosed. Methods for using transgenic mice so generated to screen for agents that effect cellular metabolism are also provided.

Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.

Abstract: A method of manufacturing a link plate for a roller chain, and the resulting link plate in which (1) the link plate has a shape comprising a pair of right and left pin holes, a pair of right and left half arcs, which are spaced outwardly from the pin holes respectively, and a pair of upper and lower straight line portions connecting both ends of the pair of right and left half arcs. There are shaved lengths along the pair of upper and lower straight line portions extending into the half arcs, the shaved length extending between the outermost positions of both ends of said pin holes.

Abstract: A method and apparatus for processing mail is provided. Mail is placed into an input bin having a conveyor that conveys the mail towards a feeder. The feeder serially feeds the envelopes by engaging the lead envelope in the stack of mail and displacing the lead envelope transverse the stack of mail. The mail is then cut on a side edge and the top edge to cut open each envelope. A transport conveys the cut envelopes to an extractor. The extractor opens the edge-severed mail and presents the contents of the envelopes to an operator who manually extracts the contents. The operator drops the extracted contents onto a conveyor that conveys the contents to an imaging station. The contents are automatically separated and imaged to obtain image data for the contents. The contents are then sorted into a plurality of output bins.

Abstract: Compositions and methods are provided for the reproducible derivation of germ cells and oocytes and spermatogonia therefrom. Also provide are methods of use of the same in reproductive and therapeutic cloning protocols.