Patents Represented by Attorney Douglas E. Reedich
  • Patent number: 5446153
    Abstract: Imidazo[4,5-c]pyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis involving the use of such compounds.
    Type: Grant
    Filed: September 8, 1994
    Date of Patent: August 29, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Kyle J. Lindstrom, Nick Nikolaides
  • Patent number: 5444065
    Abstract: 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating viral infections involving the use of such compounds.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 22, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • Patent number: 5439670
    Abstract: A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: August 8, 1995
    Assignee: Riker Laboratories, Inc.
    Inventors: Tarlochan S. Purewal, David J. Greenleaf
  • Patent number: 5416113
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents. Pharmaceutical compositions containing and pharmacological methods of using such compounds are also disclosed, as are synthetic intermediates for preparing such compounds. Certain of the synthetic intermediates also exhibit useful antiallergic activity.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: May 16, 1995
    Assignee: Riker Laboratories, Inc.
    Inventor: Robert A. Scherrer
  • Patent number: 5400920
    Abstract: A valve for delivering a metered dose of a medicinal aerosol formulation. The valve has a filling state, a filled state, a metering state, and a dispensing state. A metering chamber is formed when the device is taken from the filled state to the metering state. Once the valve has been placed in the filled state it can no longer be placed in the filling state.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: March 28, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: James B. Barnhart
  • Patent number: 5395937
    Abstract: A process that involves reacting a 3-nitroquinoline-2,4-disulfonate with an amine or a substituted amine to selectively aminate at the 4-position to yield 1H-imidazo[4,5-c]quinolin-4-amines is disclosed.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: March 7, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, Kyle J. Lindstrom
  • Patent number: 5393362
    Abstract: A method of applying a layer of exogenous inorganic oxide to a metal article which method involves heating a coating of a coupling agent for a temperature and for a time sufficient to convert the coating to a layer of exogenous inorganic oxide. Also a method of adhering a metal article to an adhesive and/or a composite and a method of adhering a metal article to a substrate.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: February 28, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Scott R. Culler
  • Patent number: 5389640
    Abstract: 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: February 14, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Stephen L. Crooks, Kyle J. Lindstrom
  • Patent number: 5385736
    Abstract: A pressure sensitive adhesive coated sheet material for delivering melatonin through the skin. The sheet material has a flexible backing bearing a pressure sensitive adhesive coating involving an acrylic copolymer, melatonin, 2-(2-ethoxyethoxy)ethanol, and optionally N,N-dimethyldodecylamine-N-oxide.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: January 31, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Joan K. Kappes, John R. Hart
  • Patent number: 5380760
    Abstract: Transdermal drug formulations containing a prostaglandin, optionally a lipophilic excipient, and a polyisobutylene pressure sensitive adhesive.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: January 10, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Hanns Wendel, Franz-Josef Braun
  • Patent number: 5372819
    Abstract: Polymer blends containing a very low density polyethylene copolymer of ethylene and 1-butene, 1-hexene, or 1-octene and about 15 to about 600 parts by weight of a linear low density polyethylene copolymer of ethylene and 1-octene, based on 100 parts by weight of the very low density polyethylene copolymer.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: December 13, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Kristin J. Godbey, Philip G. Martin
  • Patent number: 5367076
    Abstract: A process is disclosed for preparing 1-substituted-1H-imidazo[4,5-c]quinolin-4-amines. The process involves reacting a 1-substituted-1H-imidazo[4,5-c]quinoline-5-oxide with an acylating agent and reacting the product thereof with an aminating agent.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: November 22, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Patent number: 5352784
    Abstract: [6,7]-propylene-, -butylene- or -pentylene-fused imidazopyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating viral infections involving the use of such compounds.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: October 4, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • Patent number: 5347998
    Abstract: An inhalation device for use with a pressurized aerosol canister. The device involves an electromechanical mechanism for applying a priming force to the aerosol canister prior to or at the start of inhalation. The device also involves a blocking mechanism. The electromechanical mechanism electromechanically applies to the aerosol canister a priming force sufficient to actuate the aerosol canister, and the blocking mechanism prevents the priming force from actuating the aerosol canister until inhalation is detected.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: September 20, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Peter D. Hodson, Eric A. Baum, David K. Smith, Anton Kuepper, Matthew J. Wilby
  • Patent number: 5348730
    Abstract: A method for preparing a self-propelling, powder dispersing aerosol composition comprising at least 0.0001% by weight of a finely-divided solid medicament coated with a non-perfluorinated surface active dispersing agent which constitutes at least 0.0001% by weight of the coated solid material, and suspended in an aerosol propellant in which the non-perfluorinated surface-active dispersing agent is substantially insoluble. Propellant-insoluble non-perfluorinated surfactants are used to prepare stable dispersions of powdered medicament by way of pre-coating the medicament with the surfactant prior to admixture with propellant.
    Type: Grant
    Filed: March 17, 1993
    Date of Patent: September 20, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: David J. Greenleaf, Tarlochan S. Purewal, Philip A. Jinks
  • Patent number: 5346905
    Abstract: 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: September 13, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Patent number: 5347036
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents. Pharmaceutical compositions containing and pharmacological methods of using such compounds are also disclosed, as are synthetic intermediates for preparing such compounds. Certain of the synthetic intermediates also exhibit useful antiallergic activity.
    Type: Grant
    Filed: May 26, 1993
    Date of Patent: September 13, 1994
    Assignee: Riker Laboratories, Inc.
    Inventor: Robert A. Scherrer
  • Patent number: 5290539
    Abstract: A device for delivering an aerosol, comprising: a casing member, a valve stem, and a diaphragm, wherein the diaphragm comprises a thermoplastic elastomer comprising a ethylene/1-butene copolymer. Also disclosed are sealing members comprising such an elastomer and thermoplastic polymer blends, e.g., for use in sealing members of the invention. The devices of the invention are particularly useful with formulations containing 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane as the propellant.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: March 1, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Paul E. Marecki
  • Patent number: 5275212
    Abstract: A process for preparing a medicinal aerosol formulation containing a propellant that is gaseous at standard temperature and pressure and filling the formulation into a metered dose aerosol canister. The process involves mixing the propellant and the drug at ambient temperature and under pressure sufficient to liquify the propellant to afford a formulation. The formulation is cooled to a temperature sufficiently low to liquify the propellant at atmospheric pressure and filled into aerosol canisters in an environment of controlled humidity. An aerosol valve is placed on each aerosol canister and the finished canisters are removed from the controlled environment.
    Type: Grant
    Filed: February 24, 1993
    Date of Patent: January 4, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Robert A. Moris
  • Patent number: 5268376
    Abstract: 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: December 7, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gester