Abstract: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.

Abstract: The present invention is directed to high activity titanium oxide DeNOx catalysts. In preferred embodinents, by depositing vanadium oxide on a titania supported metal oxide such as tungsten oxide, an improved catalyst may be generated. This catalyst may be used in the treatment of exhaust from sources such as automobiles and industrial plants.

Abstract: This invention relates to a process for beneficiating a titaniferous ore. The process comprises leaching the titaniferous ore with sulfuric acid to form a leached ore, calcining the leached ore in the presence of oxygen to form a calcined ore, and leaching the calcined ore with sulfuric acid, hydrochloric acid, and/or nitric acid to form a beneficiated ore. The leached ore is not reduced prior to or following calcination.

Abstract: A system and method of producing an elemental material or an alloy from a halide of the elemental material or halide mixtures. The vapor halide of an elemental material or halide mixtures are introduced into a liquid phase of a reducing metal of an alkali metal or alkaline earth metal or mixtures thereof present in excess of the amount needed to reduce the halide vapor to the elemental material or alloy resulting in an exothermic reaction between the vapor halide and the liquid reducing metal. Particulates of the elemental material or alloy and particulates of the halide salt of the reducing metal are produced along with sufficient heat to vaporize substantially all the excess reducing metal. Thereafter, the vapor of the reducing metal is separated from the particulates of the elemental material or alloy and the particulates of the halide salt of the reducing metal before the particulate reaction products are separated from each other.

Abstract: The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of determining a level of toxicity in normal tissue for an anti-tumor compound. The methods include providing at least one cell type and culturing the cell type in the presence of at least one concentration of the chemical compound, measuring at least one indicator of cell health at the at least one concentration of compound for the at least one cell type, and performing a concentration response analysis, from which a toxic concentration can be determined.

Abstract: The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions which can benefit from treatment with flexible heteroarotinoids as described herein are, (1) cancers and other diseases that involve abnormal differentiation, (2) diabetes, (3) hemophilia, (4) liver disease, (5) diseases involving human aldehyde dehydrogenase 2, (6) polycystic kidney disease, (7) lysosomal storage diseases, (8) high cholesterol, (9) obesity, (10) high triglycerides, (11) glycoprotein metabolism diseases, and (12) diseases involving abnormal angiogenesis.

Abstract: A discharge valve comprising a valve body, a valve member, and a valve seat. The valve body has a first end; a second end; a central axis therebetween; an inlet formed through the first end; a flow channel extending from the inlet to the second end; a valve channel extending from the inlet and terminating within the valve body; and at least one discharge port extending from the valve channel to an outer surface of the valve body. The valve member is substantially-spherical and movably disposed within the valve channel. The valve seat is disposed adjacent the first end of the valve channel. The valve seat has an orifice defined therethrough The valve member is movable between a first position, engaging the valve seat to substantially seal the orifice, and a second position adjacent the second end of the valve channel to permit fluid to flow through the orifice.

Abstract: In combination, an identifier assembly is mounted to a tubular of a drill string to uniquely identify the tubular. The identifier assembly is provided with a radio-frequency-identification tag having a unique identification code stored therein, and means for mounting the radio-frequency-identification tag to the tubular such that the radio-frequency-identification tag is disposed outside of an arcuate external perimeter of the tubular.

Abstract: The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Pasteurella multocida hyaluronate synthase (PmHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product.

Abstract: A tie rack includes a mounting plate, a first side arm extending from the mounting plate, second side arm in a spaced apart, parallel relationship to the first side arm. A first mounting rod extends from the first side arm toward the second side arm, and a second mounting rod extends from the second side arm toward the first side arm. The second mounting rod has a distal end in a spaced apart relationship with the distal end of the first mounting rod. A drag rod extends between the first side arm and the second side arm in a spaced apart and parallel relationship to the first mounting rod and the second mounting rod such that when a tie is looped over one of the mounting rods with two portions of the tie extending therefrom, the two portions are extendable over one side of the drag rod.

Abstract: A training device having a concave ramp surface with a lower edge and an upper edge. The concave ramp surface has an angle of curvature greater than 90 degrees from the lower edge to the upper edge such that the ball traveling along the concave ramp surface from the lower edge to the upper edge is directed back over the lower edge. The angle of curvature of the concave ramp surface between the lower edge and the upper edge is variable between the first side and the second side of the body member.

Abstract: A cinch connector for connecting a cinch to a saddle. The cinch connector has a frame, a latch bar, and a tongue. The frame has a top frame member, a bottom frame member, and an intermediate frame member supported in a spaced apart, parallel relation to define a first strap receiving slot and a second strap receiving slot. The latch bar is pivotally connected to the bottom frame member and defines a catch receiving space. At least a portion of the latch bar is configured to be received through the ring of a buckle when the distal end of a catch of the buckle is disengaged from the ring so that the catch of the buckle may then be rotated through the catch receiving space of the latch bar to engage the ring of the buckle thereby capturing the latch bar to connect the cinch connector to the buckle. The tongue is pivotally connected to the bottom frame member and extendible to the intermediate frame member to fasten the strap to the cinch connector.

Abstract: An engine system comprising a secondary fuel source for providing a secondary fuel, a metering valve for delivering the secondary fuel at a substantially pre-determined rate, an air intake, and an internal combustion engine. The metering valve comprises a valve body and a selectively-adjustable static valve mechanism. The valve body is provided with a fuel inlet in fluid communication with the secondary fuel source to receive the secondary fuel from the secondary fuel source, a fuel outlet, and a fuel passage between the fuel inlet and the fuel outlet. The selectively-adjustable static valve mechanism is disposed within the fuel passage of the valve body. The air intake is in fluid communication with the fuel outlet of the metering valve to receive the secondary fuel from the metering valve to permit the secondary fuel to mix with air.

Abstract: A subsurface drainage assembly for directing fluid drainage from a surface is disclosed. The subsurface drainage assembly includes a plurality of drain structure panels linked together in a manner that permits movement of one drain structure panel relative to the adjacent drain structure panel. The drain structure panels have a laterally extensive backing grid and a plurality of spaced apart tubular support members projecting therefrom. The tubular support members are tapered so that the tubular support members are nestable with the tubular support members of an identical drain structure panel when the drain structure panels are stacked.

Abstract: Improved compositions and processes for removing photoresists, polymers, post etch residues, and post oxygen ashing residues from interconnect, wafer level packaging, and printed circuit board substrates are disclosed. One process comprises contacting such substrates with mixtures containing an effective amount of organic ammonium compound(s); from about 2 to about 20 weight percent of oxammonium compound(s); optionally organic solvent(s); and water.

Abstract: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size.

Abstract: A method for identifying compounds capable of targeting suppressed cancer cells, the method including the steps of comparing the response to a test compound of cancer cells grown on a suppressing cell support matrix which causes suppression of a malignant phenotype in a growing cancer cell and on a non-suppressing cell support matrix.

Abstract: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate synthase from Pasteurella multocida. The present invention also relates to coatings for biomaterials wherein the coatings provide protective properties to the biomaterial and/or act as a bioadhesive. Such coatings could be applied to electrical devices, sensors, catheters and any device which may be contemplated for use within a mammal. The present invention further relates to drug delivery matrices which are biocompatible and may comprise combinations of a biomaterial or a bioadhesive and a medicament or a medicament-containing liposome. The biomaterial and/or bioadhesive is a hyaluronic acid polymer produced by a hyaluronate synthase from Pasteurella multocida.