Patents Represented by Attorney Edlyn S. Simmons

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  • Aryloxy alkanols as anti-retrovirus agents
    Patent number: 5177108
    Abstract: Aryloxyalkanol derivatives having the formulaAr--O(CH.sub.2).sub.n OHwherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treatment of a retrovirus infection.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: January 5, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Sai P. Sunkara
  • 3-aryl-5-alkylthio-4H-1,2,4-traizoles for treatment of hyperreflexia due to spinal trauma
    Patent number: 5158968
    Abstract: This invention relates to the use of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and the corresponding alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from chronic hyperreflexia due to spinal trauma.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: October 27, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John H. Kehne, John M. Kane, Francis P. Miller
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 5143933
    Abstract: This invention relates to novel sulfone and sulfoxide derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and to the use of 3-aryl-5-alkylthio-, alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from convulsant seizures.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: September 1, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
    Patent number: 5100906
    Abstract: This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease and Wernicke-Korsakoff syndrome by administration of 5-(R.sub.n -phenyl)-4-alkyl-3H-1,2,4-triazole-3-thiones of the formula ##STR1## wherein R is halogen, trifluoromethyl, C.sub.1-4 lower alkyl orC.sub.1-4 lower alkoxy,n is zero, 1 or 2, andR.sub.2 represents hydrogen or C.sub.1-3 lower alkyl; andR.sub.4 independently represents C.sub.1-3 lower alkyl.
    Type: Grant
    Filed: February 26, 1991
    Date of Patent: March 31, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Jerry A. Miller
  • Aryloxy alkanols as anti-retrovirus agents
    Patent number: 5077315
    Abstract: Aryloxyalkanol derivatives having the formulaAr--O(CH.sub.2).sub.n OHwherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treatment of a retrovirus infection.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: December 31, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Roger A. Parker, Sai P. Sunkara
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 4981863
    Abstract: This invention relates to derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles, to their pharmacological properties and to their use as muscle relaxants, spasmolytics, anticonvulsants and anxiolytics.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: January 1, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: John M. Kane, Francis P. Miller
  • Antiretroviral furan ketones
    Patent number: 4980371
    Abstract: Furan ketone derivatives thereof having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula ##STR1## wherein Y is a bond, oxygen or divalent sulfur; n is 0 or 1; R is a straight or branched C.sub.8-20 alkyl chain or a straight or branched C.sub.8-20 alkenyl chain having from 1 to 4 double bonds; and R.sub.1 is C.sub.1-6 alkyl.
    Type: Grant
    Filed: November 27, 1989
    Date of Patent: December 25, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Roger A. Parker, Sai P. Sunkara
  • Antiretroviral aryloxy substituted furan ketones
    Patent number: 4977185
    Abstract: Novel furan ketone derivatives having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula ##STR1## wherein Y represents a bond, oxygen or divalent sulfur; Ar represents phenyl or naphthylenyl; n is 0 or 1; m is an integer of from 4 to 10; and R.sub.1 represents C.sub.1-6 alkyl.
    Type: Grant
    Filed: November 27, 1989
    Date of Patent: December 11, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Roger A. Parker, Sai P. Sunkara
  • 4-benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and their use as anticonvulsants
    Patent number: 4966909
    Abstract: The invention relates to 4-benzyl-5-phenyl-1,2,4-dihydro-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: October 30, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: John M. Kane, Francis P. Miller
  • 5-heterocyclic-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants
    Patent number: 4952593
    Abstract: This invention relates to novel 5-R.sub.n -(Het)-2,4-di alkyl-3H-1,2,4-triazole-3-thiones, to the intermediates and processes for their preparation, and to their use as antidepressants.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: August 28, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 5-phenyl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants
    Patent number: 4946856
    Abstract: This invention relates to 5-phenyl-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: August 7, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • Aryloxy alkanols as anti-retrovirus agents
    Patent number: 4939173
    Abstract: Aryloxyalkanol derivatives having the formulaAr--O(CH.sub.2).sub.n OHwherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treating a retrovirus infection.
    Type: Grant
    Filed: December 14, 1988
    Date of Patent: July 3, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Sai P. Sunkara
  • 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants
    Patent number: 4912095
    Abstract: This invention relates to novel 5-(R.sub.n -phenyl)-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and to their use as antidepressants.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: March 27, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 4900743
    Abstract: This invention relates to derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles, to their pharmacological properties and to their use as muscle relaxants, spasmolytics, anticonvulsants and anxiolytics.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: February 13, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • Hypoglycemic N-(2-substituted-3-dialkylamino-2-propenylidene)-N-alkylalkanaminium salts
    Patent number: 4857663
    Abstract: N-(3-Dialkylamino-2-propenylidene)-N-alkylalkanaminium salts substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.
    Type: Grant
    Filed: November 16, 1988
    Date of Patent: August 15, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Eugene R. Wagner, Donald P. Matthews, Charlotte L. Barney
  • Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione
    Patent number: 4847276
    Abstract: This invention relates to a novel method for the treatment of hemorrhagic and thrombotic thrombocytosis by means of administration of a 5-(4-chlorophenyl)-2,4-dimethyl-3H-1,2,4-triazole-3-thione.
    Type: Grant
    Filed: September 6, 1988
    Date of Patent: July 11, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: John T. Yarrington
  • Synthesis for the preparation of 4-amino-4,5-dihydro-2-furancarboxylic acid
    Patent number: 4824974
    Abstract: This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C.sub.1-6 lower alkyl esters thereof. These compounds are .gamma.-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.
    Type: Grant
    Filed: October 15, 1987
    Date of Patent: April 25, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Joseph P. Burkhart, Gene W. Holbert
  • Method of alleviating withdrawal symptoms
    Patent number: 4800209
    Abstract: The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal, pre-menstrual tension and peri-menopausal flushing is disclosed.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: January 24, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Albert Sjoerdsma
  • Hypoglycemic N-(2-substituted-3-dialkylamino-2-propenylidene)-N-alkylalkanaminium salts
    Patent number: 4788335
    Abstract: N-(3-Dialkylamino-2-propenylidene)-N-alkylalkanaminium salts substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.
    Type: Grant
    Filed: October 20, 1987
    Date of Patent: November 29, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Eugene R. Wagner, Donald P. Matthews, Charlotte L. Barney
  • Antifungal 2-anilinothiazolines
    Patent number: 4788209
    Abstract: Fungal infections of the skin and mucous membranes may be controlled by topical administration of a pharmaceutical composition comprising a N-(3- or 4-alkylphenyl)4,5-dihydro-2-thiazolamine.
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: November 29, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Russell J. Baumann, Boyd L. Harrison