Abstract: This invention relates to novel 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones, to the intermediates and processes for their preparation, and to their use as antidepressants.
Abstract: Compounds of the following general structure are useful as antirhinovirus agents: ##STR1## wherein R is a straight or branched hydrocarbon chain having from 12 to 16 carbon atoms and is saturated or is unsaturated having from 1 to 4 double bonds.
Abstract: Compounds of the following general structure are useful as antirhinovirus agents: ##STR1## wherein R is a straight or branched hydrocarbon chain having from 12 to 16 carbon atoms and is saturated or is unsaturated having from 1 to 4 double bonds.
Abstract: N-(3-Dialkylamino-2-propenylidene)-N-alkylalkanaminium salts substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.
Type:
Grant
Filed:
May 16, 1983
Date of Patent:
August 6, 1985
Assignee:
Merrell Dow Pharmaceuticals Inc.
Inventors:
Eugene R. Wagner, Charlotte L. Barney, Donald P. Matthews
Abstract: Camsylate salts of N-(3-dialkylamino-2-propenylidene)-N-alkylalkanaminium substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.
Abstract: Novel analgesic and antipsychotic agents having the formula ##STR1## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R.sub.5 is hydrogen or halogen, and R.sub.2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group ##STR2## or the group ##STR3## wherein R.sub.3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
July 19, 1982
Date of Patent:
November 20, 1984
Assignee:
Richardson Merrell Inc.
Inventors:
Albert A. Carr, Robert A. Farr, John M. Kane
Abstract: Novel compounds of the formula ##STR1## wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R.sub.1 is hydrogen, alkyl, alkoxy or halogen, and Z is carbonyl or hydroxymethylene and their pharmaceutically acceptable acid addition salts are useful as antipsychotic agents having a low potential for extrapyramidal side effects. The novel compounds are prepared from novel intermediates of formula ##STR2## or their salts wherein R has the meanings defined above and R.sub.2 is hydrogen, lower alkyl or phenyl(lower alkyl).
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ; R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutically acceptable acid addition salts of those compounds of basic character,have antisecretory activity.
Abstract: Novel analgesic and antipsychotic agents having the formula ##STR1## wherein Q is ##STR2## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R.sub.5 is hydrogen or halogen, and R.sub.2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group ##STR3## or the group ##STR4## wherein R.sub.3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
March 14, 1980
Date of Patent:
July 27, 1982
Assignee:
Richardson-Merrell Inc.
Inventors:
Albert A. Carr, Robert A. Farr, John M. Kane
Abstract: Novel compounds of the formula ##STR1## wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R.sub.1 is hydrogen, alkyl, alkoxy or halogen, X is carbonyl, hydroxymethylene or methylene, and Z is carbonyl or hydroxymethylene and their pharmaceutically acceptable acid addition salts are useful as antipsychotic agents having a low potential for extrapyramidal side effects. The novel compounds are prepared from novel intermediates of formula ##STR2## or their salts wherein R and X have the meanings defined above.