Patents Represented by Attorney Edmunde D. Riedl

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  • Chemical synthesis of flavipucine
    Patent number: 4094878
    Abstract: A method for the total chemical synthesis of flavipucine employs the condensation of 4-hydroxy-6-methyl-2-pyridone with isobutylglyoxal in alkali alkoxide. The resulting alkali salt is acylated in both the 1' and 4 positions. Treatment of the 1',4-diacyloxy derivative with excess alkaline peroxide yields flavipucine.
    Type: Grant
    Filed: May 19, 1977
    Date of Patent: June 13, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, Narindar N. Girotra, Zbigniew S. Zelawski, deceased
  • 2-R-Substituted-1,2,5-thiadiazole-3-one antimicrobials
    Patent number: 4094986
    Abstract: 2-R-substituted-1,2,5-thiadiazole-3-ones have broad spectrum antibacterial and antifungal activity. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: June 13, 1978
    Assignee: M. S. & D. (I.A.) Corp.
    Inventors: Joshua Rokach, Grant W. Reader
  • Method for the preparation of di-bicyclo[3.1.1] and [2.2.1]heptyl and di-bicyclo-[3.1.1] and [2.2.1]heptenyl ketones
    Patent number: 4091020
    Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
    Type: Grant
    Filed: August 23, 1976
    Date of Patent: May 23, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas
  • Diphenyl derivatives of polyamine compounds having a piperidine moiety
    Patent number: 4079059
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: March 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Crystalline dipilocarpinium pamoate
    Patent number: 4076942
    Abstract: This invention relates to novel crystalline dipilocarpinium pamoate useful as an agent, for lowering elevated intraocular pressure in glaucomatous patients, as well as to a process for preparing said compound and novel intermediates thereof.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: February 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee
  • Impregnated activated carbon for improved removal of malodorous compounds
    Patent number: 4072479
    Abstract: An improved process for the removal of malodorous compounds, especially sulfur-containing compounds, for example H.sub.2 S and methyl mercaptan, from gas streams containing oxygen in which a bed of activated carbon treated with NaOH and moisture is used to remove said compounds. The treatment, which may also be combined with regeneration of the activated carbon, is effected, typically, by applying to the carbon one bed volume of dilute (4-6%) NaOH solution, draining and drying with 50- 100% R.H. air.
    Type: Grant
    Filed: December 20, 1976
    Date of Patent: February 7, 1978
    Assignee: Calgon Corporation
    Inventors: Rabindra Kumar Sinha, Norman J. Wagner, Ronald S. Joyce
  • Derivatives of 6-aminopenicillanic acid
    Patent number: 4071529
    Abstract: Novel 6-methoxy and 6-thioalkyl-6-acylamidopenicillanic acids and their non-toxic pharmaceutically-acceptable salts, esters and amides which are useful as antibiotics. The products are prepared by treating an ester of 6-substituted-6-aminopenicillanic acid with an acylating agent followed by removal of the ester group. Also disclosed are novel intermediates.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: January 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama
  • Diphenyl polyamides having a cyclohexylene moiety
    Patent number: 4070400
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: January 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines
    Patent number: 4065497
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Polyamine compounds as antibacterial agents
    Patent number: 4061775
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Broad spectrum antibacterial compositions containing tris-(hydroxymethyl)-aminoethane and dicycloaliphatic-alkyl polyamines
    Patent number: 4060639
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dicyclohexyl-, dicyclohexenyl- and cyclohexylcyclohexenyl-alkyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Broad spectrum antimicrobial compositions containing tris-(hydroxymethyl)aminomethane and polyamines
    Patent number: 4058625
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines, their acid addition salts, and mixtures thereof are useful as antimicrobial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Broad spectrum antibacterial compositions containing tris (hydroxymethyl)-aminomethane and diphenyl and loweralkyl substituted diphenyl polyamines
    Patent number: 4058624
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and diphenyl and loweralkyl substituted diphenyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench
    Patent number: 4051132
    Abstract: Total synthesis methods employ 7-amino (6-amino in the case of a penicillin derivative) group in the alpha configuration. The instant invention provides a general route for preparing the 7.beta.-amino (or 6.beta.-amino) compound, through the formation of an imino-containing intermediate, followed by hydrolysis to the desired epimer. Novel intermediate products are provided. The compounds having the desired beta epimer can be converted to acylamino-antibiotics.
    Type: Grant
    Filed: December 24, 1975
    Date of Patent: September 27, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone
  • Alicyclic alkylene polyamine microorganism and algae growth inhibitors
    Patent number: 4049417
    Abstract: Novel dicyclohexyl, dicyclohexenyl and cyclohexylcyclohexenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Bruce E. Witzel, Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Composition for secondary and tertiary oil recovery
    Patent number: 4049559
    Abstract: An antimicrobial composition for secondary and tertiary oil recovery comprising a flooding composition consisting of displacement and driving fluids having incorporated therein an antimicrobially effective amount of a di-bicyclo[3.1.1] or [2.2.1] heptyl or di-bicyclo[3.1.1] and [2.2.1] heptenyl polyamines or salts thereof.
    Type: Grant
    Filed: May 18, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines and methods for their preparation
    Patent number: 4035174
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a cyclohexylene group in the polyamine moiety are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial waters where microbial control is desired.
    Type: Grant
    Filed: March 26, 1976
    Date of Patent: July 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • 6.alpha., .beta.-Substituted penicillin derivatives
    Patent number: 4035359
    Abstract: Novel 6-methoxy and 6-thioalkyl-6-acylamido-penicillanic acids and their non-toxic pharmaceutically-acceptable salts, esters and amides which are useful as antibiotics. The products are prepared by treating an ester of 6-substituted-6-aminopenicillanic acid with an acylating agent followed by removal of the ester group. Also disclosed are novel intermediates.
    Type: Grant
    Filed: July 25, 1975
    Date of Patent: July 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama
  • Dibicyclo[3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a piperidine moiety
    Patent number: 4033748
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: July 2, 1976
    Date of Patent: July 5, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • 1,8-Naphthyridine compounds
    Patent number: 4031103
    Abstract: There is described 2-amino-5,7-disubstituted-naphthyridine and 5,7-disubstituted-naphthyridin-2(1H)-one derivatives with bronchodilating and hypotensive properties prepared by the reaction of 2,6-diaminopyridine with an appropriate .beta.-diketone providing the 2-amino products. The 2-oxo analogs are prepared from the 2-amino products by treatment with nitrous acid.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: June 21, 1977
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Hayden Windsor Richard Williams, Clarence Stanley Rooney