Patents Represented by Attorney, Agent or Law Firm Edward T. Lentz
  • Cytokine inhibiting imidazole substituted hydroxamic acid derivatives
    Patent number: 5665753
    Abstract: The present invention relates to a series of novel imidazole substituted hydroxamic acid derivatives, and compositions useful thereof as inhibitors of matrix degrading metalloproteinases, in particular collagenase.
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: September 9, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: James Simpson Frazee, John Gerald Gleason, Brian Walter Metcalf
  • Stabilized tablet formulation
    Patent number: 5665390
    Abstract: Invented are stabilized tablet formulations of substituted 3,5-diene steroidal compounds. Also invented are methods of preparing stabilized tablet formulations of substituted 3,5-diene steroidal compounds.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: September 9, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Patrick Gerard Faulkner, Mark Warren Fisher, Joseph Peter Sauer, Carlos Roberto Hernandez
  • Inhibition of inflammatory lipid mediators
    Patent number: 5663053
    Abstract: Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: September 2, 1997
    Assignees: SmithKline Beecham Corporation, The Johns Hopkins University
    Inventors: James David Winkler, Deirdre Mary Bernadette Hickey, Floyd Harold Chilton, III
  • Process for preparing pyrimidyl imidazoles
    Patent number: 5663334
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: September 2, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter William Sheldrake, Timothy Francis Gallagher, Joseph Sisko
  • Water soluble camptothecin analogs
    Patent number: 5663177
    Abstract: The present invention provides a water soluble camptothecin analog of Formula I: ##STR1## which is particularly useful as an antineoplastic agent; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 2, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: David A. Berges, John J. Taggart
  • Synthesis of acid addition salts of hydroxylamines
    Patent number: 5663368
    Abstract: This invention relates to novel diastereomeric acid addition salts of homochiral hydroxylamines, to processes for obtaining such, to processes for the conversion thereof to the corresponding homochiral hydroxylamines, to certain novel homochiral hydroxylamines and the processes for using these as intermediates.
    Type: Grant
    Filed: April 11, 1996
    Date of Patent: September 2, 1997
    Assignee: Smithkline Beecham Corporation
    Inventors: Joseph R. Flisak, Stephen Torey Ross
  • Rapamycin derivatives
    Patent number: 5661156
    Abstract: Rapamycin derivatives of formula ##STR1## pharmaceutical compositions comprising such rapamycin derivatives and pharmaceutically acceptable carriers or diluents; and methods of using such derivatives to inhibit pathogenic fungal growth, cause therapeutically desirable immunosuppression, or treat carcinogenic tumors are disclosed.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: August 26, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis Alan Holt, Juan Ignacio Luengo, Leonard Walter Rozamus, Jr.
  • Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivatite
    Patent number: 5658887
    Abstract: A pharmaceutical formulation comprising a pharmaceutically acceptable salt of clavulanic acid in combination with erythromycin and another antimicrobial agent useful for the treatment of an infection by intracellular pathogens in humans or animals.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 19, 1997
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Angela Suzanne Gisby
  • Imidazole compounds, compositions and use
    Patent number: 5658903
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: August 19, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi-Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Processes and intermediates for the preparation of 2-substituted benzaldehydes
    Patent number: 5659084
    Abstract: Processes for preparing 2-substituted benzaldehydes of general formula (I), wherein: R.sub.1 is CH.sub.2 CH.sub.2 --(L.sub.1).sub.p --(CH.sub.2).sub.q --(L.sub.2).sub.r --CH.sub.2 --(T).sub.2 --Z; L.sub.1 and L.sub.2 are independently CH.sub.2 CH.sub.2, CH.dbd.CH or C.tbd.C; q is 0 to 8; p, r and s are independently 0 or 1; T is O, S, CH.sub.2, CH.dbd.CH, C.tbd.C; and Z is C.sub.1-4 alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl optionally mono substituted with CF.sub.3, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, methylthio, or trifluoromethylthio; and R.sub.2 and A are independently H, CF.sub.3, C.sub.1-4 alkyl, F, Cl, Br or I; are useful for preparing pharmaceutically active compounds.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: August 19, 1997
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Kerry Joseph Gombatz, Michael Anthony Forth, Jerome Francis Hayes, Michael Barry Mitchell, Stephen Alexander Smith
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5656636
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela Anne Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Angiotensin II receptor blocking compositions
    Patent number: 5656650
    Abstract: This invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier, an angiotensin II receptor antagonist and a second agent selected from a diuretic, a calcium channel blocker, a .beta.-adrenoceptor blocker, a renin inhibitor, or an angiotensin converting enzyme inhibitor and a method of treating hypertension.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corp.
    Inventor: Joseph Weinstock
  • Compositions containing histamine-H.sub.2 -receptor antagonists at low dosage
    Patent number: 5656652
    Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham plc
    Inventor: Adrian Francis Davis
  • Dispensing device
    Patent number: 5655517
    Abstract: A device for dispensing a comminuted liquid to the upper respiratory tract, which comprises an electrohydrodynamic comminution means and a means for supplying a liquid to the comminution means. And a device for comminuting a liquid, the comminution site sit of which is provided by fibres projecting from an end surface or edge, the edge or surface being composed substantially of fibres.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 12, 1997
    Assignee: Electrosols, Ltd.
    Inventor: Ronald Alan Coffee
  • Pyridyl imidazoles
    Patent number: 5656644
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Toothbrush with resiliently flexible head
    Patent number: 5651158
    Abstract: A toothbrush having a handle and at one end having a bristle-bearing head which is in the form of one or more segments which are flexibly and/or resiliently linked to each other. Optionally, the head may also be flexibly and/or resiliently linked to the handle. The grooves between the linked segments of the head are wholly or partly filled with an elastomeric material. In one aspect, the bristle-bearing head of the toothbrush is attached to the handle by a frame which wholly or partly surrounds the head and is an integral extension of the handle.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: July 29, 1997
    Assignee: Lingner & Fischer GmbH
    Inventor: Hans Halm
  • Hemoregulatory peptides
    Patent number: 5652219
    Abstract: The invention provides compounds of general formula (I). The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the prevention and treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: July 29, 1997
    Assignee: SmithKline Beecham Corporation
    Inventor: Pradip Kumar Bhatnagar
  • Combined confectionery and chewing gum
    Patent number: D381485
    Type: Grant
    Filed: July 5, 1995
    Date of Patent: July 29, 1997
    Assignee: Lingner & Fischer GmbH
    Inventor: Jurgen Reinhardt
  • Pharmaceutical tablet
    Patent number: D383533
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: September 9, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: John Michael Jushchyshyn, Ricky Holland
  • Pharmaceutical tablet
    Patent number: D383534
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: September 9, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: John Michael Jushchyshyn, Ricky Holland