Patents Represented by Attorney, Agent or Law Firm Edward T. Lentz
  • Method of diagnosing and monitoring colorectal cancer
    Patent number: 5726061
    Abstract: Methods of screening for colorectal cancer by measuring levels of HC gp-39 are provided. Methods of monitoring patients with colorectal cancer are also provided. In addition, kits for detection of HC gp-39 useful in screening for and monitoring of colorectal cancer in a patient are provided.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: March 10, 1998
    Assignee: SmithKline Beechum Corporation
    Inventors: David Robbins, Robert B. Kirkpatrick, Stephen D. Holmes
  • Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
    Patent number: 5726165
    Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, or solvate thereof, wherein,R.sup.o represents an aryl group, optionally substituted;X represents O or S;R.sup.1 and R.sup.1a each independently represents hydrogen or an alkyl group;R.sup.2 represents OCH.sub.2 CO.sub.2 H, or an ester or amide thereof, or R.sup.2 represents a moiety of formula (b): ##STR2## wherein R.sup.4 represent hydrogen, alkyl, hydroxyalkyl, arylalkyl, aralkyloxyalkyl or cycloalkyl and R.sup.5 represent hydroxy, alkoxy, arylalkyloxy, hydroxyalkyloxy, alkoxyalkyloxy, arylalkoxyalkyloxy, cycloalkyloxy, hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, arylalkyl, arylalkyloxyalkyl or R.sup.5 together with OR.sup.4 represents O(CH.sub.2).sub.n O wherein n is 2, 3 or 4; andR.sup.3 represents hydrogen, halogen, alkyl or alkoxy or R.sup.3 together with R.sup.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 10, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Lee James Beeley, Mervyn Thompson, David Kenneth Dean, Nikesh Rasiklal Kotecha, John Michael Berge, Robert William Ward
  • Enzymatic preparation of monic acids
    Patent number: 5726049
    Abstract: A process for the production of monic acids which comprises contacting a corresponding pseudomonic acid or an ester thereof with a hydrolase enzyme from a suitable microorganism, in particular Streptomyces sp.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: March 10, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Esme Faith Hayes, John Thomas Sime, Stefan Roland Woroniecki, David Alan Yeandle
  • Coumarin derivatives as retroviral inhibitors
    Patent number: 5723631
    Abstract: The present invention relates to a process for the preparation of a compound of the following structure: ##STR1## wherein, substituents are as defined in the specification.
    Type: Grant
    Filed: June 22, 1995
    Date of Patent: March 3, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Ashok Dharmaji Patil, Robert Philip Hertzberg, Geoffrey B. Dreyer, Alan James Freyer, John W. Westley, Balan Chenera, Michael Leo West
  • 3,3-(disubstituted)cyclohexan-1-01 dimers and related compounds
    Patent number: 5723681
    Abstract: The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ol dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: March 3, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski
  • NERF genes
    Patent number: 5721113
    Abstract: Isolated nucleic acids encoding human lymphoid-specific transcription factors NERF-1 and NERF-2, proteins obtainable from the nucleic acids, recombinant host cells transformed with the nucleic acids and use of the proteins and nucleic acid sequences are dislcosed.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: February 24, 1998
    Assignee: Human Genome Sciences, Inc.
    Inventors: Towia Aron Libermann, Joerg Peter Oettgen, Charles A. Kunsch
  • Endothelin receptor anatagonists
    Patent number: 5719182
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Pharmaceutical compositions containing a calcitonin
    Patent number: 5719122
    Abstract: Pharmaceutical compositions comprising a calcitonin and a polyglycolysed glyceride and a method of enhancing the transdermal or transmucosal absorption of calcitonin in a mammal are disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Farmaceutici S.p.A.
    Inventors: Laura Chiodini, Teodoro Fonio, Gianfranco Rancati
  • Intermediate for preparing a pharmaceutically active compound
    Patent number: 5719293
    Abstract: This invention relates to a compound of formula (I) and hydrates, solvates, and salts thereof.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Corporation
    Inventor: Raymond E. Dagger
  • Endothelin receptor antagonists
    Patent number: 5719183
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • 3,3-(disubstituted)cyclohexan-1-carboxylate dimers and related compounds
    Patent number: 5719184
    Abstract: The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-carboxylate dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski
  • Pyridyl substituted imidazoles
    Patent number: 5716972
    Abstract: The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati
  • Endothelin receptor antagonists
    Patent number: 5716985
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Maria Amparo Lago
  • Endothelin receptor antagonists
    Patent number: 5716984
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott
  • Container with ramp action closure
    Patent number: 5715960
    Abstract: A container and closure combination wherein the closure comprises a skirt portion, the periphery of which has at least one rounded ramped portion adapted to cooperate with one or more corresponding rounded ramped portions on the container such that relative axial rotation of the container causes cooperation of the ramped portions and disengagement of the closure from the container.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Richard William Seymour
  • Substituted imidazole compounds
    Patent number: 5716955
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: February 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm
  • Method of treating sepsis
    Patent number: 5714469
    Abstract: The invention relates to the method of preventing and treating sepsis using (S)-5-oxo-L-prolyl-L-.alpha.-glutamyl-L-.alpha.-aspartyl-N.sup.8 -(5-amino-1-carboxypentyl)-8-oxo-N.sup.7 -?N-?N-(5-oxo-L-prolyl)-L-.alpha.-glutamyl!-L-.alpha.-aspartyl!-L-threo-2, 7,8 triaminooctanoyl-lysine ?(pGlu-Glu-Asp).sub.2 -Sub-(Lys).sub.2 ! alone or in conjunction with an anti-infective agent.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: February 3, 1998
    Assignee: SmithKline Beecham Corporation
    Inventor: Peter Lawrence DeMarsh
  • Treating cardiovascular disease with steroidal 5-alpha-reductase inhibitors
    Patent number: 5714480
    Abstract: Invented is a method of treating cardiovascular disease by employing a steriod 5-alpha-reductase inhibiting compound.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: February 3, 1998
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert Howard Palmer
  • Rapamycin derivative with antimicrobial, anticancer and immunomodulation activity
    Patent number: 5712129
    Abstract: A compound of formula (I) is obtainable by the cultivation of a genus Streptomyces, such as Streptomyces NCIMB 40515. in the presence of rapamycin, and recovery thereof from the culture medium. The compound, and pharmaceutical compositions containing it, is useful as an immunomodulatory agent as an anticancer agent, or in the treatment of microbial infections in animals including humans.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: January 27, 1998
    Assignee: SmithKline Beecham p. l. c.
    Inventor: Brian Douglas Ford
  • Azalicyclooctane derivatives as anti-arrhythmic agents
    Patent number: 5712284
    Abstract: A compound of formula (I) or a salt thereof, or a solvate thereof: ##STR1## wherein B represents a C.sub.1-4 n-alkylene group wherein each carbon is optionally substituted by a C.sub.1-6 alkyl group; Z represents a bond, CH.sub.2, (CH.sub.2).sub.2 or X--CH.sub.2 --CH.sub.2 wherein X represents O or S; D represents CO, SO.sub.2, NH--CO or NH--SO.sub.2 ; T represents a bond and U represents CH.sub.2 or T represents CH.sub.
    Type: Grant
    Filed: February 14, 1996
    Date of Patent: January 27, 1998
    Assignee: SmithKline Beecham Laboratoires Pharmaceutiques
    Inventors: Guy Marguerite Marie Gerard Nadler, Michel Louis Souchet