Abstract: N-(aminoalkyl)-substituted(N or C alkyl)-aryl-4-(methylsylfonylamino)benzamides of the formula ##STR1## wherein R is C.sub.1 -C.sub.4 straight chain alkyl, one of R.sub.1, R.sub.2 and R.sub.3 is a phenyl or naphthyl group and the others are hydrogen, --NR.sub.4 R.sub.5 is a secondary or teritary amino group, X and X.sub.1 are hydrogen or alkyl and n is 0 or 1, are useful as antiarrhythmic agents in the treatment of cardiac arrhythmias especially as combination Class I/Class III agents.

Abstract: Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.

Abstract: This invention relates to a process for the preparation of substituted sulfonamidobenzamides which compounds are known antiarrhythmic agents and to the novel N-acylaziridine employed therein.

Abstract: A modular tissue superfusion chamber includes a receptacle support having a recess therein for receiving one of a plurality of modular bath containers which hold tissue samples being tested for electrophysiological responses to compounds. The receptacle support has a Peltier heater therein and is mounted on a magnetic base with a plurality of pillars.

Abstract: Novel 1-(4-substituted phenyl)-1H-imidazoles and their use as antiarrhythmic, anti-hypertensive and anti-ischemic agents is described. Pharmaceutical formulations containing such compounds are also discussed.

Abstract: A tablet container having a cover and sliding tray is used for dispensing birth control tablets for either a twenty-one-day or twenty-eight-day cycle. Normally, the tray does not slide completely out of the cover and is stabilized with respect thereto when open. The case resembles a cosmetic compact and is reuseable in that once birth control tablets contained in a blister pack are used up, a new blister pack may easily be inserted.

Abstract: Novel substituted 4-[1H-imidazol-1-yl]benzamides and their use in the treatment of cardiac arrthythmias especially as Class III or combination Class I/III antiarrhythmic agents is described. Pharmaceutical formulations containing such compounds are also disclosed.

Abstract: Orally active prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2 -one are disclosed. Pharmaceutical formulations containing such compounds are also provided.

Abstract: Novel imidazolylphenylpyrrol-2-ones are described as having cardiovascular properties especially as cardiotonic agents in the treatment of congestive heart failure. Pharmaceutical formulations containing such compounds are also described.

Abstract: Novel imidazolonecarbonylarylimidazoles are described having cardiovascular properties, especially as cardiotonic agents in the treatment of congestive heart failure. Pharmaceutical formulations containing such compounds are also provided. Further, a novel process for the preparation of the compounds and intermediates useful thereto of this invention is disclosed.

Abstract: A system and apparatus for containing and dispensing medications in a prescribed manner, and for reducing the possibility of incorrect dosages being taken and/or medication being taken at the wrong time of the day. A tray contains plural rows and columns of cavities, and each cavity is adapted to contain medication therein. The cavities include structure dividing them into two parts. A first part is open to the user to enable the user to place medication therein and to remove medication therefrom. A second part is closed off from direct access by the user in semi-permanent fashion by a transparent enclosure and is used to contain in a preferred embodiment, an exemplification of a appropriate dosage of medication to be taken. For example, if five green pills are to be taken, the enclosed portion will contain five green pills viewable through the transparent enclosure. The dose example of medication contained therein is the dose amount and type medication to be placed in each open cavity structure each day.

Abstract: The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.

Abstract: A novel, orally administrable pro-drug form of dobutamine of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof.

Abstract: Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.

Abstract: A bipolar electrode is a disc of bio-compatable material. Wires are passed through the disc and terminate on one side in bead shaped electrode means of conductive material and out the other end to a power supply. The conductive material is, in one aspect, silver. In one embodiment, the disc is silicone rubber. In another and preferred embodiment the disc is of polypropylene mesh permitting tissue ingrowth and secure attachment.

Abstract: The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.

Abstract: Novel quinuclidines, their acid addition, quaternary ammonium and inner salts are described. Also provided is the method of using these compounds as antiarrhythmic agents and pharmaceutical formulations containing such compounds.

Abstract: This invention relates to novel substituted imidazo[1,2-a]pyridines, most especially novel 8-phenylimidazo[1,2-a]pyridines and a process for their preparation. The compounds of the invention have been found to have cardiotonic antiarrhythmic, CNS stimulant, CNS depressant and other pharmacological effects.

Abstract: The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.

Abstract: This invention relates to novel benzodiimidazole diols and diones and their ability to sensitize hypoxic cells to radiation, thus demonstrating utility for enhancing the treatment of solid tumors by radiation in a subject in need of such treatment.