Patents Represented by Attorney Elizabeth A. Bellamy

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Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones

Patent number: 4556665

Abstract: Novel imidazolonecarbonylarylimidazoles of the formula: ##STR1## are described having cardiovascular properties, especially as cardiotonic agents in the treatment of congestive heart failure. Pharmaceutical formulations containing such compounds are also provided. Further, a novel process for the preparation of the compounds and intermediates useful thereto of this invention is disclosed.

Type: Grant

Filed: July 9, 1984

Date of Patent: December 3, 1985

Assignee: Schering A.G.

Inventors: Paul W. Erhardt, Alfred A. Hagedorn, III, William C. Lumma, Jr., Ronald A. Wohl
Substituted phenylalkenyl ammonium salts as antiarrhythimc agents

Patent number: 4545995

Abstract: The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such ammonium salts.

Type: Grant

Filed: July 12, 1983

Date of Patent: October 8, 1985

Assignee: Schering A.G.

Inventors: William C. Lumma, Jr., Ronald A. Wohl
Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof

Patent number: 4544654

Abstract: Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.

Type: Grant

Filed: March 20, 1984

Date of Patent: October 1, 1985

Assignee: Schering A.G.

Inventors: David D. Davey, William C. Lumma, Jr., Ronald A. Wohl
N-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]-1H-benzimidazole-1-butanamine and use thereof as a cardiotonic agent

Patent number: 4517310

Abstract: The compound N-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]-1H-benzimidazole-1-butanamine and methods for its manufacture and use are described herein. The compound is a cardiotonic agent useful primarily in the treatment of congestive heart failure.

Type: Grant

Filed: July 28, 1981

Date of Patent: May 14, 1985

Assignee: Berlex Laboratories, Inc.

Inventors: Julius Diamond, Ronald A. Wohl
Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines

Patent number: 4434174

Abstract: 3-Phenoxy-2-hydroxypropylamines having an N-benzimidazolyalkyl substituent and similar compounds are described herein. They are obtained by the reaction of the appropriate imidazole-1-alkanamine with an epoxide, and they are useful primarily as .beta..sub.1 -agonists/.beta.-sympathomimetic agents.

Type: Grant

Filed: March 2, 1982

Date of Patent: February 28, 1984

Assignee: Berlex Laboratories, Inc.

Inventors: Julius Diamond, Ronald A. Wohl
Method of use of antiarrhythmic 1-arylcarbamoylalkyl imidazole derivatives, composition

Patent number: 4415587

Abstract: Novel 1,2-disubstituted imidazol(in)es are described herein. The compounds are generally produced by reacting a haloacylanilide with an excess of 2-substituted-imidazol(in)e. The compounds are antiarrhythmic agents.

Type: Grant

Filed: August 12, 1982

Date of Patent: November 15, 1983

Assignee: Berlex Laboratories, Inc.

Inventors: Julius Diamond, Thomas K. Morgan, Jr., Ronald A. Wohl
N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines

Patent number: 4363808

Abstract: 3-Phenoxy-2-hydroxypropylamines having an N-benzimidazolyalkyl substituent and similar compounds are described herein. They are obtained by the reaction of the appropriate imidazole-1-alkanamine with an epoxide, and they are useful primarily as .beta.-adrenergic blocking agents.

Type: Grant

Filed: May 7, 1981

Date of Patent: December 14, 1982

Assignee: Berlex Laboratories, Inc.

Inventors: Julius Diamond, Ronald A. Wohl
Antiarrythmic 1-arylcarbamoylalkyl-2-imidazoline derivatives, composition and method of use

Patent number: 4353921

Abstract: Novel 1,2-disubstituted imidazol(in)es are described herein. The compounds are generally produced by reacting a haloacylanilide with an excess of 2-substituted-imidazol(in)e. The compounds are antiarrhythmic agents.

Type: Grant

Filed: June 19, 1981

Date of Patent: October 12, 1982

Assignee: Berlex Laboratories, Inc.

Inventors: Julius Diamond, Thomas K. Morgan, Jr., Ronald A. Wohl
Process for the preparation of chiral 3-amino-2-hydroxypropionic acid and N-blocked derivatives thereof

Patent number: 4296242

Abstract: This invention describes a novel process whereby D-glucose and D-mannose are converted to S-3-amino-2-hydroxypropionic acid and R-3-amino-2-hydroxypropionic acid, respectively, and their N-blocked derivatives.

Type: Grant

Filed: June 6, 1979

Date of Patent: October 20, 1981

Assignee: Schering Corporation

Inventors: Tattanahalli L. Nagabhushan, Alan Cooper
Process for the preparation of 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy derivatives produced thereby

Patent number: 4284764

Abstract: A novel process whereby 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols are reacted with a dialkylaminosulfur trifluoride to produce novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents.

Type: Grant

Filed: February 19, 1980

Date of Patent: August 18, 1981

Assignee: Schering Corporation

Inventors: Peter J. L. Daniels, Dinanath Rane
Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diam inocyclitols

Patent number: 4282350

Abstract: This invention describes a novel process whereby 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diamin ocyclitols are selectively acylated at the 3"-N-position with 1-Z-imidazole, wherein Z is an amino protecting group; to produce novel 1-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diaminocycli tols.

Type: Grant

Filed: August 5, 1977

Date of Patent: August 4, 1981

Assignee: Schering Corporation

Inventor: John J. Wright
Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them

Patent number: 4272525

Abstract: This invention relates to derivatives of polyene macrolide antibiotics containing an amino sugar moiety, the process for their preparation and pharmaceutical compositions containing them useful in the treatment of fungal infections.

Type: Grant

Filed: March 7, 1980

Date of Patent: June 9, 1981

Assignee: Schering Corporation

Inventor: John J. Wright
6"-Amino derivatives of 4-0-aminoglycosyl-6-0-garosaminyl-1,3-diaminocyclitols

Patent number: 4243801

Abstract: Novel 6"-amino derivatives of 4-0-aminoglycosyl-6-0-garosaminyl-1,3-diaminocyclitols, useful as antibacterial agents, are described.

Type: Grant

Filed: July 12, 1979

Date of Patent: January 6, 1981

Assignee: Schering Corporation

Inventor: John J. Wright
17.alpha.-Chloro-17.beta.-hydrocarbonsulfinyl-1,4-androstadienes and the corresponding 17.beta.-hydrocarbonsulfonyl derivatives and their use as anti-acne agents

Patent number: 4183924

Abstract: Novel 17.alpha.-chloro-17.beta.-hydrocarbonsulfinyl and 17.alpha.-chloro-17.beta.-hydrocarbonsulfonyl derivatives of 3-oxo-1,4-androstadienes and their use as anti-acne agents are described.

Type: Grant

Filed: February 27, 1978

Date of Patent: January 15, 1980

Assignee: Schering Corporation

Inventors: Michael J. Green, Robert Tiberi
1-N-substituted derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols

Patent number: 4180565

Abstract: Novel 1-N-aminoalkyl (oxycarbonyl or carboxamido or thiocarboxamido) derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful as antibacterial agents, are described.

Type: Grant

Filed: May 25, 1978

Date of Patent: December 25, 1979

Assignee: Schering Corporation

Inventors: Alan K. Mallams, David H. Davies
2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor

Patent number: 4171356

Abstract: The preparation of novel 2'-unsubstituted derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful as antibacterial agents, is described.

Type: Grant

Filed: October 28, 1976

Date of Patent: October 16, 1979

Assignee: Schering Corporation

Inventors: John J. Wright, Alan K. Mallams
Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor

Patent number: 4085208

Abstract: This invention relates to the preparation of novel 1-epi-aminoglycosides, useful as antibacterial agents, and also relates to the process for the preparation of known as well as novel 1-N-substituted aminoglycoside antibacterial agents.

Type: Grant

Filed: June 21, 1976

Date of Patent: April 18, 1978

Assignee: Schering Corporation

Inventors: Alan K. Mallams, David Huw Davies
1-Desamino-1-hydroxy and 1-desamino-1-epi-hydroxy-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols; 1-desamino-1-oxo-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, intermediates and use as antibacterial agents

Patent number: 4066752

Abstract: This invention relates to the preparation of novel 1-desamino-1-oxo-aminoglycosides and their use as intermediates in the preparation of novel 1-desamino-1-hydroxy and 1-desamino-1-epi-hydroxyaminoglycoside antibacterial agents.

Type: Grant

Filed: June 21, 1976

Date of Patent: January 3, 1978

Assignee: Schering Corporation

Inventors: Alan K. Mallams, David Huw Davies
Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor

Patent number: 4062947

Abstract: 1,2'-di-N-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and 1,6'-di-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and their acid addition salts are valuable as antibacterial agents. Also disclosed are 2'-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents which are also useful as intermediates in the preparation of the 1,2'-di-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols. Preferred compounds of this invention include 1,2'-di-N-ethylsisomicin and 1,6'-di-N-ethylsisomicin.

Type: Grant

Filed: July 19, 1976

Date of Patent: December 13, 1977

Assignee: Schering Corporation

Inventors: John J. Wright, Peter J. L. Daniels, Alan K. Mallams, Tattanahalli L. Nagabhushan
Combined medication dispenser and cassette

Patent number: D275833

Type: Grant

Filed: November 16, 1981

Date of Patent: October 9, 1984

Assignee: Berlex Laboratories, Inc.

Inventor: Jack W. Malpass

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