Patents Represented by Attorney Elizabeth Arwine

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  • Automated method of identifying and archiving nucleic acid sequences
    Patent number: 6871147
    Abstract: A method of identifying and archiving a nucleic acid sequence includes a) creating a directory of files in a computer, for storing information related to the nucleic acid sequence; b) inputting a raw nucleic acid sequence into the computer; c) trimming the raw nucleic acid sequence to obtain a trimmed nucleic acid sequence; d) submitting the trimmed nucleic acid sequence electronically to a nucleic acid identification database having a search program and receiving search results electronically from the nucleic acid identification database; e) choosing selective information from each search result and inserting the selective information from each search result into a first electronic spreadsheet; and f) selecting at least one of the search results from the first electronic spreadsheet and inserting the at least one search result into a second electronic spreadsheet.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: March 22, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John J. Schlager, Richard E. Sweeney, Douglas P. Avery
  • Method for treating, preventing, or inhibiting enterotoxigenic Escherichia coli infections with bovine red blood cells
    Patent number: 6869602
    Abstract: Disclosed herein are RBC preparations and methods of making and using thereof for treating, preventing or inhibiting ETEC infections. In particular, bovine red blood cell (RBC) preparations are shown to reduce enterotoxigenic Escherichia coli (ETEC) adhesion when administered orally. Also disclosed are kits comprising RBC preparations for the treatment of ETEC infections.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: March 22, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hyoik Ryu, Frederick J. Cassels
  • Ricin vaccine and methods of making and using thereof
    Patent number: 6869787
    Abstract: Disclosed herein are polypeptides and variants thereof comprising a polypeptide sequence having substantial identity to ricin A chain (RTA) that lack detectable N-glycosidase-rRNA activity or exhibit reduced N-glycosidase-rRNA activity as compared to controls and methods of making and using thereof. The polypeptides and variants have a greater solubility in aqueous solutions of physiological pH and ionic strength than RTA and also retain the integrity of the neutralizing immunological epitope of wild type RTA. Also disclosed are immunogenic compositions that may be used to immunize a subject against ricin intoxication. Methods of immunizing against, treating, and preventing ricin intoxication are disclosed.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: March 22, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Mark A. Olson, Charles B. Millard, Michael P. Byrne, Robert W. Wannemacher, Ross D. LeClaire
  • Isolation and purification of P. falciparum merozoite protein-142 vaccine
    Patent number: 6855322
    Abstract: This application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: February 15, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jeffrey A. Lyon, Evelina Angov
  • Sustained release hydrophobic bioactive PLGA microspheres
    Patent number: 6855331
    Abstract: A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophobic bioactive agent over a duration from 24 hours to 100 days comprising: and a blend of end-capped uncapped biocompatible, biodegradable poly(lactide/glycolide).
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: February 15, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Noelle Christine Vook, Elliott Jacob, Jean A. Setterstrom, John van Hamont, William Vaughan, Ha Duong
  • System and method for determining visual alertness
    Patent number: 6849050
    Abstract: In one embodiment, a method is characterized by presenting a first pattern of light during a first interval of time: recording a first-pattern response set; presenting a second pattern of light during a second interval of time; recording a second-pattern response set; and assessing visual alertness in response to the first-pattern response set and the second-pattern response set. In one embodiment, a related system includes but is not limited to circuitry and/or programming for effecting the foregoing-referenced method embodiment; the circuitry and/or programming can be virtually any combination of hardware, software, and/or firmware configured to effect the foregoing-referenced method embodiment depending upon the design choices of the system designer.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: February 1, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Michael B. Russo, Saul Santiago
  • Critical care platform for litters
    Patent number: 6842922
    Abstract: The invention preferably includes a platform for attaching to patient carrying devices such as litters. The platform preferably is capable of attaching to accessory clips connected to medical instruments that are useful for carrying for a patient.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: January 18, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Eric M. Smeed
  • Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
    Patent number: 6844010
    Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: January 18, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jean A. Setterstrom, John E. Van Hamont, Robert H. Reid, Elliot Jacob, Ramasubbu Jeyanthi, Edgar C. Boedeker, Charles E. McQueen, Daniel L. Jarboe, Frederick Cassels, William Brown, Curt Thies, Thomas R. Tice, F. Donald Roberts, Phil Friden
  • Low-backscatter aperture structure
    Patent number: 6834971
    Abstract: A system including but not limited to a low-backscatter aperture structure, where the system can include but is not limited to a camera, an optical communications system, an imaging system, a test system, and a measurement system.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: December 28, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Clarence E. Rash, John C. Mora
  • Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same
    Patent number: 6825323
    Abstract: The combination of recombinant factor VIIa and fibrinogen is effective in treatment for bleeding where direct pressure, tourniquets, indirect pressure, surgical ligation, bandaging, and transfusion of blood or plasma products are typically used. The combination of factor VIIa and fibrinogen is administered intravenously, either sequentially or simultaneously. The compositions may be safely circulated in the blood vessels to sites of injury. This is effective for single or multiple external or internal wounds.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: November 30, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: John R. Hess
  • Prophylactic and therapeutic monoclonal antibodies
    Patent number: 6824778
    Abstract: In this application are described monoclonal antibodies which recognize E3 glycoprotein of alphavirus and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of alphavirus infections in vitro and in vivo.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: November 30, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Mary Kate Hart
  • Trifluoromethylepinephrine compounds and methods of making and using thereof
    Patent number: 6825382
    Abstract: Disclosed herein are trifluoromethylepinephrine compounds having the following structural formula (I) wherein R1-R5 are each independently selected from the group consisting of H, alkyl, alkoxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, acyl, thioacyl, sulfonyl mercapto, alkylthio, carboxy, amino, alkylamino dialkylamino, carbamoyl, arylthio, and heteroarylthio; wherein X, Y, and Z are each independently selected from the group consisting of H or trifluoromethyl with the proviso that at least one of which is trifluoromethyl. Also disclosed are pharmaceutical compositions comprising the trifluoromethylepinephrine compounds and methods of making and using thereof. Novel trifluoroepinephrine intermediates are also disclosed.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: November 30, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Jeffrey R. Ammann
  • Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
    Patent number: 6815425
    Abstract: A nueroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH2 or a combination of pGLU-GLU-PRO-NH2 (EEP) and N-tert-Butyl-&agr;-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and injuries of the brain, spinal cord and retina is also presented by administering the endogenous tripeptide EEP to a subject as a neuroprotectant or by administering EEP in combination with SPBN or other nitrone.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 9, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: James L. Meyerhoff, Michael L. Koenig, Joseph B. Long
  • Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof
    Patent number: 6800618
    Abstract: A compound having the structural formula or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4, 5 or 6; Y is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or wherein R1 and R2 are each independently, H, a heteroatom, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and wherein each ring structure are independently substituted or unsubstituted is disclosed. Also disclosed are chemosensitizing agents and methods of modulating, attenuating, reversing, or affecting a cell's or organism's resistance to a given drug such as an antimalarial.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: October 5, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ai J. Lin, Jian Guan, Dennis E. Kyle, Wilbur K. Milhous
  • Mass spectrometry of colonization factors
    Patent number: 6797485
    Abstract: Disclosed herein are methods for identifying at least one bacterial colonization factor of enterotoxigenic E. coil which comprise the following steps in the following order: 1) obtaining the colonization factor; 2) solubilizing the colonization factor by dissolving the colonization factor in 1,1,1,3,3,3-hexafluoro-2-propanol; 3) adding a solution of volatile acid to the solubilized colonization factor of step 2 to obtain a product; 4) subjecting the product of step 3 to mass spectrometry to determine the mass of the colonization factor; and 5) comparing the mass determined in step 4 with the mass of at least one known colonization factor.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: September 28, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Frederick J. Cassels, Lewis K. Pannell
  • Anthrax vaccine
    Patent number: 6770479
    Abstract: Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: August 3, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John S. Lee, Peter Pushko, Michael D. Parker, Jonathan F. Smith, Susan L. Welkos
  • High throughput assays for the proteotytic activities of clostridial neurotoxins
    Patent number: 6762280
    Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: July 13, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: James J. Schmidt, Robert G. Stafford
  • Securing device for an endotracheal tube
    Patent number: 6755191
    Abstract: A securing device for an endotracheal tube preferably includes a shield having an opening through which the endotracheal tube can pass and a clamp mounted on the shield for holding the endotracheal tube. A bite block for preventing occlusion of the endotracheal tube by a patient's teeth may be mounted on an opposite surface of the shield from the clamp.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: June 29, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Todd M. Bertoch, Ted F. Gingrich, Steven C. Walker, John M. Shepherd
  • Protein biomarker for mustard chemical injury
    Patent number: 6753155
    Abstract: This invention relates to the discovery that toxicity to mustard may be evaluated by diagnostic test means disclosed herein. Upon electrophoretic separation (sodium dodocyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE)) of buffered extract of human skin cells (normal human epidermal keratinocytes (NHEK)) which had been exposed to mustard-type chemical compounds a band at approximately 50,000 to 80,000 daltons molecular weight was found. The protein band constitutes a biomarker.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: June 22, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Prabhati Ray
  • Portable medical digital radiography assembly
    Patent number: 6754306
    Abstract: A portable medical digital radiography apparatus includes a ruggedized transport case housing several system components, a digital X-ray image sensor and an X-ray generator. The digital X-ray image sensor is hingedly coupled to a stand that is mounted to the ruggedized transport case. The X-ray generator is preferably positioned opposite to the center of digital X-ray image sensor. A patient support unit is disposed between digital X-ray image sensor and the X-ray generator. An image acquisition unit is connected to the X-ray generator and to the digital X-ray image sensor and fixedly mounted in the ruggedized transport case. An image display unit is connected to the image acquisition unit and spaced from the X-ray generator.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: June 22, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth Cho, Mark Freckleton, Peter Martin