Patents Represented by Attorney Elizabeth Arwine

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  • Attenuated dengue-2 virus vaccine
    Patent number: 6511667
    Abstract: The present invention provides vaccine compositions of attenuated dengue-2 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-2 virus by administration of attenuated dengue-2 virus.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: January 28, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph R. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, David Vaughn, Erik A. Henchai, Niranian Kanesa-thasan
  • Botulinum neurotoxin vaccine
    Patent number: 6495143
    Abstract: Using the nontoxic heavy chain fragment from botulinum neurotoxins A-G, compositions and methods of use in inducing an immune response which is protective against intoxication with botulinum in subjects is described.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: December 17, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John S. Lee, Peter Pushko, Jonathan F. Smith, Michael Parker, Mark T. Dertzbaugh, Leonard Smith
  • Critical care platform for litters
    Patent number: 6493890
    Abstract: This invention preferably includes a platform (100) having a support surface (110), a pair of legs (150, 150) connected to the support surface (110), and footings (152) and securing mechanism (160 or 180) on the legs (150, 150) for attaching the invention to a litter that preferably satisfies NATO requirements. Preferably, the invention attaches to the poles used to carry a patient on a litter such that the invention provides space for the patient's legs to pass under if necessary. A further embodiment of the invention adds at least one accessory clip, which preferably includes at least one attachment for a piece of medical equipment such as medical monitors, ventilators, and infusion pumps.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: December 17, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Eric M. Smeed
  • Active topical skin protectants
    Patent number: 6472437
    Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: October 29, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ernest H. Braue, Jr., Stephen T. Hobson, Erich K. Lehnert
  • Active topical skin protectants containing S-330
    Patent number: 6472438
    Abstract: A topical skin protectant formulation containing a barrier cream and a reactive moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and a reactive moiety that serves to neutralize chemical warfare agents into less toxic agents.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: October 29, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ernest H. Braue, Jr., Millard M. Mershon, Catherine R. Braue, Ruth A. Way
  • Method of treating, preventing or inhibiting central nervous system injuries and diseases
    Patent number: 6469049
    Abstract: Methods of preventing, treating, or both preventing and treating CNS injury, disease, neurotoxicity or memory deficit in a subject by the administration of at least one lipoic acid compound to the subject are disclosed. Examples of CNS injuries or disease include traumatic brain injury (TBI), posttraumatic epilepsy (PTE), stroke, cerebral ischemia, neurodegenerative diseases of the brain such as Parkinson's disease, Dementia Pugilistica, Huntington's disease and Alzheimer's disease, brain injuries secondary to seizures which are induced by radiation, exposure to ionizing or iron plasma, nerve agents, cyanide, toxic concentrations of oxygen, neurotoxicity due to CNS malaria or treatment with anti-malaria agents, and other CNS traumas.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: October 22, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: James L. Meyerhoff, Debra L. Yourick, Michael L. Koenig
  • Pacifier pulse oximeter sensor
    Patent number: 6470200
    Abstract: A pacifier pulse oximeter sensor includes pulse oximeter sensor elements located within the nipple of a pacifier. The pulse oximeter sensor elements may be completely within the nipple material, embedded within the nipple material, nested within the nipple material, or adjacent to the nipple material while not being exposed to the outside environment. The pulse oximeter sensor elements include a light source and a light detector. The pulse oximeter sensor elements communicate with an oximeter through wiring, an electrical connector, and/or wirelessly. An alternative embodiment adds oximeter processing capabilities to the pacifier pulse oximeter sensor.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: October 22, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Steven C. Walker, John G. Alexander, John M. Shepherd
  • Prophylactic and therapeutic monoclonal antibodies
    Patent number: 6451309
    Abstract: In this application are described vaccinia monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of vaccinia virus infections in vitro and in vivo.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: September 17, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jay W. Hooper, Alan L. Schmaljohn, Connie S. Schmaljohn
  • Sustained release hydrophobic bioactive PLGA microspheres
    Patent number: 6447796
    Abstract: A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophocib bioactive agent over a duration from 24 hours to 100 days comprising: and a blend of end-capped uncapped biocompatible, biodegradable poly(lactide/glycolide).
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: September 10, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Noelle Christine Vook, Elliott Jacob, Jean A. Setterstrom, John van Hamont, William Vaughan, Ha Duong
  • Prolonged storage of red blood cells
    Patent number: 6447987
    Abstract: Novel additive solutions useful for the storage of human red blood cells (RBCs) under refrigerated conditions are disclosed. Also disclosed is a method of using the additive solutions in an appropriate volume to preserve RBCs at about 1 to 6° C. for up to at least about 11 weeks or more. Additive solutions and processes in accordance with the present invention allow the viable storage of human RBCs for an extended period of time in a solution which is directly infusible in humans.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: September 10, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John R. Hess, Tibor J. Greenwalt
  • Live vaccine against Brucellosis
    Patent number: 6444445
    Abstract: Live Brucella vaccines and methods for preparing the live vaccines protective against brucellosis are described. The vaccines are prepared by introducing a deletion in the rfbU gene of a strain of Brucella which results in attenuation of the strain while retaining the desired immunogenicity to initiate a protective immunogenic response. Other strains with varying levels of attenuation are described.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: September 3, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Mikeljon P. Nikolich, David L. Hoover, Richard L. Warren, Luther E. Lindler, Ted L. Hadfield, Gerhardt G. Schurig, Stephen M. Boyle, John R. McOulston, Nammalwar Sriranganathan
  • Active topical skin protectants using polymer coated metal alloys
    Patent number: 6437005
    Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 20, 2002
    Assignees: The United States of America as represented by the Secretary of the Army, Mainstream Engineering Corporation
    Inventors: Stephen T. Hobson, Ernest H. Braue, Jr., Dwight Back
  • Compositions having anti-leishmanial activity
    Patent number: 6433023
    Abstract: This invention is directed to a composition comprising 4-chloro-3,6-dinitrobenzotrifluoride and related compounds and method for using it to treat infections caused by organisms that have microtubules.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: August 13, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Heather Callahan, Colleen Kelley, Max Grogl, Brian G. Schuster
  • Treatment of and/or prophylaxis against brain and spinal cord injury
    Patent number: 6432434
    Abstract: The administration of &agr;-lipoic acid (&agr;LA) and dihydrolipoic acid (DHL) both as a preventive measure before exposure to conditions which may cause damage, such as rapid changes in atmospheric pressure, and as a means of preventing or ameliorating damage arising from such injury provides benefits not currently available. The active agents may be administered systemically or to the injured tissue. For example, when there is spinal cord injury, the active agents may be administered intrathecally.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: August 13, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: James L. Meyerhoff, Joseph Long, Michael Koenig
  • Active topical skin protectants using polyoxometallates
    Patent number: 6420434
    Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: July 16, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ernest H. Braue, Jr., Stephen T. Hobson, James White, Richard Bley
  • Convertible patient isolation pod
    Patent number: 6418932
    Abstract: A convertible isolation pod for an individual patient formed from sealable flexible plastic sheeting including an air intake grommet at the head end and an air exhaust grommet at the foot end of the pod each of the grommets being equipped with a Heimlich valve to provide unidirectional air flow within the pod where the air is filtered to remove contaminants.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: July 16, 2002
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Charles R. Paschal, Jr., Orlando J. Illi, George W. Haubeil, James R. Gauger, Robert L. Mullins, Jr.
  • Method for predicting human cognitive performance
    Patent number: 6419629
    Abstract: An apparatus and method for predicting cognitive performance of an individual based on factors including sleep history and the time of day. The method facilitates the creation of predicted cognitive performance curves that allow an individual to set his/her sleep times to produce higher levels of cognitive performance. The method also facilitates the reconstruction of past cognitive performance levels based on sleep history.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: July 16, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Thomas J. Balkin, Gregory L. Belenky, Stanley W. Hall, Gary H. Kamimori, Daniel P. Redmond, Helen C. Sing, Maria L. Thomas, David R. Thorne, Nancy Jo Wesensten
  • Active topical skin protectants using hybrid organic polysilsesquioxane materials
    Patent number: 6417236
    Abstract: A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: July 9, 2002
    Assignees: The United States of America as represented by the Secretary of the Army, The Regents of the University of California
    Inventors: Stephen T. Hobson, Ernest H. Braue, Kenneth Shea
  • Icon for a portion of a display screen
    Patent number: D463445
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: September 24, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Stephen W. Hoxie, André Akers
  • Icon for a portion of a display screen
    Patent number: D463446
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: September 24, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Stephen W. Hoxie, André Akers