Abstract: A spill of acid is controlled and cleaned up by being neutralized by a low metal ion fluid neutralizer composition formed of a non-volatile organic amine compound, a foam-forming surfactant and a pH indicator dye and which can additionally contain water, a dissolved gas and color tinting agents. Such a neutralizer composition is especially useful in the electronics manufacturing industry and in clean rooms where the presence of metal ions would be deleterious.
Type:
Grant
Filed:
March 20, 1978
Date of Patent:
November 13, 1979
Assignee:
J. T. Baker Chemical Company
Inventors:
James W. Seidenberger, Francis W. Michelotti
Abstract: Novel 7-[2-[.omega.-(1,3-dithiolan-2-imino)substituted]-acetylamino]cephalospora nic acid derivatives are described having useful antibacterial activity.
Abstract: Novel bis-basic ethers of 9-substituted phenanthrene and related 10-oxa and 10-aza derivatives, their method of preparation and their use as pharmaceutical agents for the prevention and inhibition of viral infections are disclosed.
Type:
Grant
Filed:
November 11, 1976
Date of Patent:
October 2, 1979
Assignee:
Richardson-Merrell Inc.
Inventors:
Donald R. Meyer, Arthur D. Sill, Paul L. Tiernan
Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic acitivity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
Type:
Grant
Filed:
February 14, 1978
Date of Patent:
May 8, 1979
Assignee:
Richardson-Merrell Inc.
Inventors:
Johann M. Grisar, Thomas R. Blohm, Edward M. Roberts
Abstract: Novel vinyl derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; Z is R.sub.1 OCCH.dbd.CH-- or R.sub.1 OC(CH.sub.2).sub.n -- wherein n is an integer of from 1 to 3; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, or ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and the lactams thereof when Z is R.sub.1 OC(CH.sub.2).sub.
Abstract: Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an effective quantity of an active ingredient are disclosed herein. The active ingredients are those compounds having the formula ##STR1## wherein A is a straight or branched alkylene chain of from 1 to 6 carbon atoms and each Y is the group(A) ##STR2## wherein R.sup.1 and R.sup.2 are each individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or(B) ##STR3## wherein n is a whole integer of 4, 5 or 6 and R.sup.3 is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl and can be attached to any one of the carbon atoms of the heterocyclic group; or(C) ##STR4## wherein X is oxygen or N--R.sup.4 and R.sup.
Abstract: Substituted furoic acids and esters and pharmaceutically acceptable salts thereof of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y represents oxygen or divalent sulfur; R represents a straight or branched alkyl chain containing from 10 to 20 carbon atoms and may be saturated or may be unsaturated containing from 1 to 4 double bonds; R.sup.1 represents hydrogen, straight or branched lower alkyl of from 1 to 6 carbon atoms, benzyl, phenethyl, pyridylmethyl, alkane-poly-yl containing from 3 to 6 carbon atoms, 1,2,3,4,5,6-cyclohexanehexayl, or Z; Z represents ##STR2## wherein n is an integer of 2 or 3; R.sup.2 represents straight or branched lower alkyl of from 1 to 4 carbon atoms, or acyl; R.sup.3 represents hydrogen or straight or branched lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sup.3 is hydrogen, R.sup.2 is acyl; or when R.sup.2 is other than acyl, R.sup.2 and R.sup.
Abstract: The present invention concerns derivatives of 19-oxygenated-androst-5-enes which are useful in the enhancement of libido and related psychic attitudes.
Abstract: Novel acetylenic derivatives of amines of the following general structure: ##STR1## WHEREIN Z is .beta.-methylthioethyl, .beta.-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, .gamma.-guanidinopropyl, or ##STR2## WHEREIN N IS 2 OR 3 AND R.sub.1 is hydrogen or lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sub.1 is other than hydrogen, n is 2; and each of R.sub.a and R.sub.b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR3## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; with the provisos that when Z is .beta.-benzylthioethyl or S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, R.sub.b is hydrogen, and when Z is ##STR4## EACH OF R.sub.a and R.sub.
Abstract: Novel halomethyl derivatives of amines of the following general structure: ##STR1## WHEREIN Y is FCH.sub.2 --, F.sub.2 CH-- or F.sub.3 C--; Z is .beta.-methylthioethyl, .beta.-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, .gamma.-guanidinopropyl, or ##STR2## WHEREIN N IS 2 OR 3 AND R.sub.1 is hydrogen or lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sub.1 is other than hydrogen, n is 2; and each of R.sub.a and R.sub.b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR3## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; with the provisos that when Z is .beta.-benzylthioethyl or S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, R.sub.b is hydrogen, when Z is .beta.-methylthioethyl, Y is other than F.sub.
Abstract: Novel acetylenic derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein n is an integer of from 1 to 3; R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, of ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and the lactams thereof when n is 2 or 3; and pharmaceutically acceptable salts and individual optical isomers thereof.
Abstract: Pathogenic infectious bovine rhinotracheitis (IBR) virus may be modified by serial passages in non-bovine tissue cultures until it becomes non-pathogenic when applied to the intranasal passages of bovines. Such application will result in the induction of high levels of interferon in nasal secretions as well as the production of local antibodies and a long lasting immunity against IBR infection by virtue of the induction of specific circulating antibodies. The invention includes the method of modifying the IBR virus, a method of preparing a vaccine therefrom and a method of immunizing bovines and promoting production of high levels of interferon in nasal secretions.