Abstract: An apparatus includes an electrical lead comprising a lead body and an electrical conductor, and an electrode coupled to the electrical conductor, wherein the electrode includes a coating on at least a portion of a surface of the electrode, the coating including two or more layers, with a first layer adjacent the surface of the electrode comprising an insulative material and a second layer adjacent the first layer comprising at least one pharmacological agent.

Abstract: A miniature piezoelectric transducer element is provided, comprising; (a) a cell element having a cavity; (b) a flexible piezoelectric layer attached to the cell member, the piezoelectric layer having an external surface and an internal surface, the piezoelectric layer featuring such dimensions so as to enable fluctuations thereof at its resonance frequency upon impinging of an external acoustic wave; and (c) a first electrode attached to the external surface and a second electrode attached to the internal surface of the piezoelectric layer. At least one of the electrodes may be specifically shaped so as to provide a maximal electrical output, wherein the electrical output may be current, voltage or power. A preferred shape of the electrodes includes two cores interconnected by a connecting member. The transducer element may function as a transmitter.

Abstract: A medical electrical lead configured to be coupled to a pulse generator in a cardiac rhythm management system. The lead comprises a proximal terminal connector configured for coupling the lead to the pulse generator, and a plurality of longitudinally arranged lead segments each configured to exhibit one or more predetermined physical characteristics based on the implantation location for the respective segment. The lead segments may be pre-fabricated as separate modules optimized for the operating environment and/or delivery requirements of the respective segments. The pre-fabricated modules are longitudinally arranged and joined to form the lead.

Abstract: A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.

Abstract: A system and method for administering a therapeutic treatment to the heart includes a pressure sensor positioned in the pulmonary artery, an implantable medical device located remotely from the sensor, and communication means for communicating pressure data from the pressure sensor to the implantable medical device. The system includes a control module operatively coupled to the implantable medical device. The control module is adapted for comparing the pulmonary arterial pressure data to a pre-programmed value, adjusting an operating parameter of the implantable medical device based on the relationship of the pulmonary arterial pressure to the pre-programmed value, and repeating this process until the relationship between the pulmonary arterial pressure data and the pre-programmed value is such that no adjustment is necessary.

Abstract: An implantable medical device comprising a housing and an ultrasonic transducer having a communication frequency coupled to a portion of the housing. The housing resonates at the communication frequency, and a casing is coupled to the housing and disposed over the ultrasonic transducer. The casing is adapted to amplify the deformation of the ultrasonic transducer in a bending mode and transfer the bending moment to the housing. An implantable medical device comprising a housing having an upper portion and a lower portion. A first ultrasonic transducer is coupled to a first connection rod and is coaxial with the first connection rod. The first ultrasonic transducer and first connection rod are interposed between the upper and lower portions such that the first ultrasonic transducer is adapted to vibrate the upper and lower portions simultaneously. A method of optimizing an ultrasonic transducer and a housing of an implantable medical device.

Abstract: A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. They can be used alone or in combination with other therapies to treat cancer and other cell proliferative diseases. Representative compounds of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide and N,N-diethyl-N-allyl-3-(2-methyl-9H-thioxanthen-9-ylidene)-propane-1-aminium bromide, were shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. These compounds had even greater effects on tumor volume, body weight, and survival when administered together with the human protein placental alkaline phosphatase.

Abstract: A guide catheter for accessing the coronary sinus ostium has a proximal portion and a distal portion formed into a preformed shape including a curved segment. The preformed shape includes a first arc, a second arc, a third arc, a fourth arc, and a generally straight terminal portion. The preformed shape is generally a J-shape, having a terminal portion generally parallel to the proximal portion, a generally closed arc or a generally open arc.

Abstract: A mixer for combining ingredients using a composite shaking and tumbling motion. The mixer includes a base carrier rotating about a primary axis and supporting a container carrier assembly having a clamp retaining a container to be mixed. The container carrier assembly is coupled to the base carrier to oscillate in an eccentric manner with respect to the rotating base carrier. The container carrier assembly also rotates with the base carrier rotation. The composite resulting motion includes shaking and tumbling components of the motion to mix the ingredients. The clamp has a first housing portion receiving the container, and a second housing portion movable with respect to the first portion to retain the container. A latch selectively retains the first and second housing portions together in a closed condition.

Abstract: In one embodiment, an external programming device is operable to determine and graphically display power consumption of an implantable medical device (“IMD”). In accordance with this particular embodiment, the external programming device includes a graphical user interface display and a communication interface operable to receive information from an IMD. In this embodiment, the external programming device is operable to receive IMD parameter settings and/or battery parameter values from the IMD, calculate a power consumption rate for the IMD, and then display the power consumption on the graphical user interface display using a graphical visual indicator.

Abstract: An ancillary tool for fitting a humeral component of a total or partial elbow prosthesis, comprising a guiding tool (30) for boring a humeral trochlea (T) along a geometric axis (X-X?) of bend of a joint to be equipped with said prosthesis. The guiding tool (30) includes a stirrup element (31) and means (32b, 33b) for securing said stirrup element on the humeral trochlea (T) so that said guiding tool defines a guiding zone that is aligned in the geometric axis of bend for the introduction (F1) of a drill (40), a punch or the like, in the humeral trochlea (T) along said geometric axis of bend. This ancillary tool also comprises at least one stepped template (701, 702, 703) for determining an anterior offset of said geometric axis of bend (X-X?) with respect to a humeral diaphyseal axis (Y-Y?).

Abstract: Systems, apparatuses and methods for securing tissue to bone using a bone anchoring system are described. Methods and apparatuses may allow transformation between locked and unlocked states, thereby allowing adjustment of the tension in the suture. The apparatus and/or methods may allow unidirectional movement of a suture, while preventing slippage or movement of the suture and tissue in the opposite direction. Ends of a suture may be individually tensioned to adjust positioning of a tissue with respect to a bone.

Abstract: A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.

Abstract: The present invention provides a cardiac vascular occlusion system which includes inner and outer guide catheters and an occluding member disposed on the inner catheter. The occluding member may be deployed from a compressed to an expanded position to limit retrograde blood flow in a body lumen. The occluding member may be used when injecting a contrast agent into the body lumen.

Abstract: The present invention provides methods and devices for enhancing the delivery of treatment devices for treating the annulus of an intervertebral disc. The methods and devices may employ delivery support elements to delivery tools used to deliver expandable treatment devices to the intervertebral disc. Fixation devices and methods are also disclosed, which may help to secure the treatment device in place.

Abstract: A mortarless masonry structure comprising a plurality of regular masonry blocks and/or bricks connected to each other by a plurality of metal bars and a plurality of standard metal threaded fasteners thereby forming a post tensioned structure. Preferably, the blocks are operatively connected to each other as a structure by simple mechanical tools. Each interconnection results in a unitized post tensioned member that, when interconnected to the adjacent members, forms a comparatively higher strength structure than systems made of mortar and reinforced mortar. The method used to create this structure is a simple, waterless, mortarless interconnection process that is completed by a series of simple individual steps of fastening the blocks and bars into a strong and durable structure. Once connected the structure is strong and durable. If desired, the structure may be disassembled and the components re-used.

Abstract: Systems and methods for determining a trend in vertical track modulus are described. Vertical deflection data is collected along a particular section of railroad track. A first set of vertical track modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of railroad track to be used in determining a second set of vertical track modulus. At least the first and second sets of vertical track modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the railroad track.

Abstract: An all stainless steel grounding electrode uses a coating of stainless steel for an upper collar which has a dual purpose cable connector. The cable connector can accommodate a cable lug and bolt connection or a cad weld connection. A cap for the collar has a one quarter turn dual heavy duty thread set to prevent corrosion from locking up the cap. An osmotic material is placed and replaced in the grounding electrode via the cap.

Abstract: An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.