Abstract: This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides, which advantageously also inhibit and interfere with HBV viral assembly by blocking the interaction between HBV core protein and HBV surface proteins. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using them.

Abstract: Improved procedures for cardiopulmonary resuscitation of a victim of cardiac arrest are provided. In the resuscitation, the victim's chest is mechanically compressed and decompressed to stimulate the heart. The victim is induced to inspire and expire against insufflating breathing gas during the chest compression/decompressions. The breathing gases are adduced under pressure to promote the development of a positive coronary perfusion pressure. Electro-stimulation of the heart can be carried after positive coronary perfusion pressures have been achieved. The electro-stimulation can be defibrillation or heart pacing or both. The chest compression/decompression cycles and the electro-stimulation measures are synchronized to promote sufficiently body circulation of oxygenated blood in a subject suffering from cardiac arrest. Medical equipment systems are provided for implementing the CPR procedures.

Abstract: A programmable logic device (“PLD”) is augmented with programmable clock data recover (“CDR”) circuitry to allow the PLD to communicate via any of a large number of CDR signaling protocols. The CDR circuitry may be integrated with the PLD, or it may be wholly or partly on a separate integrated circuit. The circuitry may be capable of CDR input, CDR output, or both. The CDR capability may be provided in combination with other non-CDR signaling capability such as non-CDR low voltage differential signaling (“LVDS”). The circuitry may be part of a larger system.

Abstract: Systems and methods for assessing an individual's physiological condition are provided. Cycle and shape parameters are derived from a recorded time trace containing heart rate data collected while an individual performs a cyclic exercise routine. Individually tailored exercise regimens that are based on these parameters are generated and modified as desired.

Abstract: Systems and methods for reducing delays between successive write and read accesses in multi-bank memory devices are provided. Computer circuits modify the relative timing between addresses and data of write accesses, reducing delays between successive write and read accesses. Memory devices that interface with these computer circuits use posted write accesses to effectively return the modified relative timing to its original timing before processing the write access.

Abstract: General purpose methods for the fabrication of integrated circuits from flexible membranes formed of very thin low stress dielectric materials, such as silicon dioxide or silicon nitride, and semiconductor layers. Semiconductor devices are formed in a semiconductor layer of the membrane. The semiconductor membrane layer is initially formed from a substrate of standard thickness, and all but a thin surface layer of the substrate is then etched or polished away. In another version, the flexible membrane is used as support and electrical interconnect for conventional integrated circuit die bonded thereto, with the interconnect formed in multiple layers in the membrane. Multiple die can be connected to one such membrane, which is then packaged as a multi-chip module. Other applications are based on (circuit) membrane processing for bipolar and MOSFET transistor fabrication, low impedance conductor interconnecting fabrication, flat panel displays, maskless (direct write) lithography, and 3D IC fabrication.

Abstract: The invention, in various embodiments, is directed to a solid-state flow generator and related systems, methods and applications.

Abstract: Circuitry and methods allow signal detection based entirely on differential voltage pairs. An incoming differential data signal is processed by separate full-wave rectifiers to extract high and low peak voltage envelopes. The rectifiers utilize negative feedback to ensure accurate envelope detection, and can detect peaks regardless of incoming signal polarity. The extracted envelopes are compared to a differential pair of threshold voltages. If the envelope signals have a smaller voltage difference than that of the threshold signals, the final output of the detector indicates that a loss-of-signal condition has occurred. Fully differential operation makes the detector independent of common-mode voltage, and thus more robust.

Abstract: The invention provides a highly efficient, rapid, and cost effective method of linking nucleic acid components in a predetermined order to produce a nucleic acid multicomponent construct. The invention further provides nucleic acid components, each nucleic acid component comprising a double stranded nucleic acid molecule having at least one single stranded 5? or 3? terminal sequence, the terminal sequence having sufficient complementarity to either a terminal sequence in a separate nucleic acid component or to a sequence in a linking nucleic acid molecule so as to allow for specific annealing of complementary sequences and linkage of the components in a predetermined order. Kits containing reagents required to practice the method of the invention are also provided.

Abstract: Systems and methods are provided for using an electronic program guide application to access a non-program guide application. The electronic program guide application provides a program guide display from which a user can access the non-program guide application. The electronic program guide application receives a user selection to access the non-program guide application from the program guide display. In response to the user selection, the electronic program guide application accesses the non-program guide application.

Abstract: A valve assembly has a valve housing and a valve core body movable therewithin for providing a smooth and continuous outflow of liquid from a container, which may be unvented and rigid, through a liquid-out passageway, and provides an air-back passageway for drawing external air into the container. In a preferred embodiment, the core is rotatable within the housing by one-handed actuation. The air-back passageway is preferably a channel provided on the surface of the core body, and the liquid-out passageway is preferably provided between openings in the core body.

Abstract: A stiffening system for the perimeter edges of a foam core mattress comprising a coil spring (or other spring-based) structure disposed along one or more perimeter edges (e.g., one or both side edges, the foot, the head, or a combinations thereof including the foot and both side edges) of a mattress having a foam sleeping area. The perimeter spring structure is rectangular or square in cross-section and provides sufficient stiffness for comfortable seating on the edges of the mattress and is joined to the foam core by planar fabric elements that span the joint between them and are attached to both. The sleep area provides the softness and other salutary effects of a foam sleeping surface while the stiffer spring perimeter element provides the rigidity need for comfortable seating and wear resistance.