Abstract: A pseudo-push-pull DC:DC converter topology replaces one primary switching transistor with a high speed passively switched diode coupled between one end of a transformer first primary winding and ground. A second primary winding is coupled to ground via a solid state switch that is driven with a control circuit that outputs a single drive signal of slightly less than 50% duty cycle. The other ends of the first and the second transformer primaries are coupleable to a source of Vin. The topology includes a gapped transformer whose transformer core stores sufficient electromagnetic energy when the solid state switch is turned-on by the control circuit to drive a load coupled to the transformer secondary when the solid state switch is turned-off. When the solid state switch is turned-off by the control circuit, the diode self-biases on, coupling the first transformer primary winding between Vin and ground, as though a perfectly driven solid state switch were turned-on.

Abstract: Conditioning oil for use on bowling lanes. The oil contains a mixture of mineral oil, a leveling agent, and an antistatic agent. The mineral oil is a combination of paraffin and petroleum based mineral oils and/or a polyalphaolefin synthetic oil, and in some embodiments, the mixture also includes a flow agent, a fluorescent whitening agent, a lubricity agent, and a surfactant.

Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.

Abstract: Three-dimensional computer graphics systems and methods and more particularly to structure and method for a three-dimensional graphics processor and having other enhanced graphics processing features. In one embodiment the graphics processor is a Deferred Shading Graphics Processor (DSGP) comprising an AGP interface, a command fetch & decode (2000), a geometry unit (3000), a mode extraction (4000) and polygon memory (5000), a sort unit (6000) and sort memory (7000), a setup unit (8000), a cull unit (9000), a mode injection (10000), a fragment unit (11000), a texture (12000) and texture memory (13000) a phong shading (14000), a pixel unit (15000), a backend unit (1600) coupled to a frame buffer (17000). Other embodiments need not include all of these functional units, and the structures and methods of these units are applicable to other computational processes and systems as well as deferred and non-deferred shading graphical processors.

Abstract: An improved modular masthead for use in cellular communications networks is described. The masthead unit includes a power amplifier, a duplexer and a local power supply that supplies the power amplifier. The power amplifier is arranged to amplify outgoing communication signals received from a base station. In a preferred embodiment, the masthead also includes a low noise amplifier for amplifying incoming communication signals and passing the amplified incoming communication signals to an associated base station. With this arrangement, the masthead forms a modular unit that is distinct from the base station such that the modular masthead may be replaced independently of the base station. With this arrangement the range of a cell within a cellular network may be changed by simply swapping an existing masthead unit with a second masthead unit having a different power supply thereon and making software changes in the system.

Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Abstract: A stress-free wafer comprising a substrate formed of a semiconductor material having front side and back side planar and parallel surfaces and having a thickness which can be as thin as 1 to 2 mils. The front side has electronic circuitry therein with exposed contact pads. The back side is ground and polished so that the wafer is substantially stress free and can withstand bending over a 2″ radius without breaking or damaging.

Abstract: An improved flash EEPROM memory-based storage subsystem includes one or more flash memory arrays, each with a duplicity of data registers and a controller circuit. When data are read from a flash array into a data register, the data is copied to a second register so that, during the ensuing program operation into the same array, the data may be transferred to the controller for the purpose of checking the data validity. This creates an improved performance system that doesn't suffer data transfer latency during copy operations but that is able to guarantee the validity of the data involved in such operations.

Abstract: This invention concerns novel methods and compositions useful for directly and rapidly analyzing the biochemical components of microorganisms. The compositions and methods of the present invention obviate the need for extracting and purifying the biochemicals prior to analysis.

Abstract: A portable computer. The computer includes a base, a display member, and an arm assembly coupling the display member to the base. The arm assembly includes a pair of spaced arm portions and a rigid connecting portion extending between the arm portions. The arm portions each have a first end pivotally coupled to the base edge for movement of the arm assembly between a closed position with the arm portion substantially parallel to the base and an open position with the arm portion oriented at an angle relative to the base, and a second end pivotally coupled to the display edge for pivotal movement of the display member relative to the arm portion to move the display member between a plurality of positions relative to the arm member.

Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents. In a preferred embodiment the methods include detecting a change in an optical property around a microsphere on an array.

Abstract: The invention includes novel fusion nucleic acids encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides. The fusion nucleic acids comprise four nucleic acids which encode a fusion polypeptide comprising first, second, third and fourth amino acid sequences. The first nucleic acid encodes a signal polypeptide functional as a secretory sequence in a first filamentous fungus. The second nucleic acid encodes a secreted polypeptide or functional portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third nucleic acid encodes a cleavable linker while the fourth nucleic acid comprises at least two nucleic acids encoding desired polypeptides.

Abstract: A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which exude from the lesion, means to prevent the ingress of bacteria and other cellular debris from the lesion and means to ensure that substantially all said active agent is directed to the de-epithelialized lesion.

Abstract: A method of forming Supercondtuctors with high critical temperature is described in which heterostructures at the atomic limit are realized artificially by molecular beam epitaxy, sputtering, lithography, chemical synthesis, electrochemical deposition or other similar technologies, made by a plurality of first portions of a superconducting metallic material forming a lattice of substantially equal elements with constant period &lgr;p, at least in a first direction (y), and a plurality of second portions formed by a material with different electronic structure from that of the first portions, intercalated to the first portions to realize the separation between said first portions; the heterostructure is characterized by the fact that the plurality of first portions have a size (L) and a period (&lgr;p) as to satisfy the condition for the shape resonance condition for the electrons at the Fermi level and the plurality of second portions have a size (W) smaller or of the order of the superconducting Pippard cohe

Abstract: A decoder is used in an end-to-end scalable video delivery system operable over heterogeneous networks. The decoder may software-based and computationally low complexity, or may be implemented inexpensively in ROM hardware. The system utilizes a scalable video compression algorithm based on a Laplacian pyramid decomposition to generate an embedded information stream. At the receiving end, the decoder extracts from the embedded stream different streams at different spatial and temporal resolutions. Decoding a 160×120 pixel image involves only decompressing a base layer 160×120 pixel image. Decoding a 320×240 pixel image involves decompressing and up-sampling (e.g., interpolating) the base layer to yield a 320×240 pixel image to which is added error data in a first enhancement layer following its decompression.

Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.

Abstract: Method of enhancing blood flow in tissue wherein an implant is non-ablatively introduced into the tissue in order to stimulate production of angiogenic agents by the tissue, the agents produced by the tissue are absorbed into the implant, where they are stored, and the stored agents are released back into the tissue when the production of agents by the tissue subsides. The implant is fabricated of a bioresorbable material and is resorbed into the tissue after the agents are released. In some embodiments, an exogenous angiogenic agent in included in the implant and released into the tissue along with the agents which are produced by the tissue and absorbed by the implant.

Abstract: Vibratory tuning fork having a body of piezoelectric material with a base and a pair of tapered tines which extend from the base and decrease in lateral dimension from the base toward the tips of the tines. A crotch section at the base of the tines has an inner pair of faces which lie in crystallographic planes of the piezoelectric material and an outer pair of faces which lie in additional crystallographic planes of the material and extend between the inner pair of faces and the tines. An isolation slot is formed in the base adjacent to the crotch, with enlarged cut-outs at the ends of the slot to prevent the formation of facets and membranes across the slot.

Abstract: There is described a capacitive micromachined ultrasonic transducer array which is configured to minimize the excitation and propagation of plate waves traveling in the substrate and ultrasonic waves propagating at the interface between the array surface and the immersion fluid.