Abstract: Novel synthetic transcriptional modulators having at least one selected ligand linked to at least one transcriptional modulating portion are described. The transcriptional modulators of the present invention can include a ligand linked to a chemical moiety. These transcriptional modulators can be used to selectively control gene expression and to identify components of the transcriptional machinery.

Abstract: The systems and methods described herein relate to LED systems capable of generating light, such as for illumination or display purposes. The light-emitting LEDs may be controlled by a processor to alter the brightness and/or color of the generated light, e.g., by using pulse-width modulated signals. Thus, the resulting illumination may be controlled by a computer program to provide complex, predesigned patterns of light in virtually any environment.

Abstract: Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.

Abstract: Modified proteins, modified interferons .alpha.'s and .beta.'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-.alpha.-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-.alpha.-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-.alpha.-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.

Abstract: The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.

Abstract: The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides.

Abstract: A high throughput enzyme screen has been developed which relies on metal chelate interaction for capture of the product of the enzymatic reaction. In the present assay system, a detectable moiety is attached to a substrate having a chelating capturable moiety, which can be captured by an immobilized metal. Detection is effected due to the presence of a detectable label on the reaction product immobilized on the solid phase. Only signal associated with tagged protein bound to the solid phase is detected. The present assay can reliably measure enzyme activity, and has high reproducibility, which benefits high throughput screening.

Abstract: Method and compositions for treating type II diabetes; and type II diabetes diagnostics are disclosed

Abstract: The present invention provides a novel method for the early prediction of a propensity to develop chronic obstructive airway disorders such as asthma. The present invention also provides kits for the early determination of the propensity to develop such a disorder. The method consists of detecting the presence of one or more alleles of an IL-1B haplotype, specifically the IL-1b (+3954) and the IL-1B (-511) loci. The presence of allele 2 at the IL-1b (+3954) locus indicates increased risk for a chronic obstructive airway disorder. The presence of allele 2 at the IL-1B (-511) locus indicates susceptibility to more severe expression of chronic obstructive airway disorders.

Abstract: A method for chemical vapor deposition using a very fine atomization or vaporization of a reagent containing liquid or liquid-like fluid near its supercritical temperature, where the resulting atomized or vaporized solution is entered into a flame or a plasma torch, and a powder is formed or a coating is deposited onto a substrate. The combustion flame can be stable from 10 torr to multiple atmospheres, and provides the energetic environment in which the reagent contained within the fluid can be reacted to form the desired powder or coating material on a substrate. The plasma torch likewise produces the required energy environment, but, unlike the flame, no oxidizer is needed so materials stable in only very low oxygen partial pressures can be formed.

Abstract: A power-driven hammer has a tool holder a middle bore portion which is supported inside a housing and urged backward by a compression spring. The rear end of a large bore portion of the tool holder is slidably fitted into a spline ring which is secured to the front end of a middle housing. Spline grooves are formed in the inner periphery of the spline ring at its front end while spline gears are formed on the outer periphery of the large bore portion. When the spline grooves and the spline gears are engaged with each other, the tool holder, being urged backward, is locked with its rotation prohibited. This tool holder can be temporarily unlocked to allow its rotation by sliding a change ring cover forward and the tool holder itself, thereby disengaging the large bore portion from the spline ring.

Abstract: An optical fiber which modifies the optical signals propagated through the fiber and has refractive properties which change in response to electromagnetic energy. The outer surface of the fiber forms at least one groove extending along a selected length of the fiber for receiving an electrode, which would apply an electrical voltage to the fiber resulting in a change of the refractive properties of the fiber.

Abstract: The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of chiral or prochiral substrates that contain reactive .pi.-systems, in the present of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product.

Abstract: The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.

Abstract: The systems described herein include a surgical instrument having an elongate shaft member, a slide mounted thereon, a handle with two legs, a disengagement mechanism permitting the mounted slide to be removed from the elongate shaft member, and a lock mechanism preventing slide disengagement. In one embodiment, the handle comprises a first and a second handle leg, the second handle leg pivotable around the first handle leg, and the second handle leg having a proximal end bearing an axially directed slot that permits engagement with a cross-pin. In this embodiment, maximal spreading of the two handle legs inclines the slot in the proximal end of the second handle leg in a proximal direction, permitting the disengagement of the crosspin from the slot when the slide is retracted to its most proximal position. One embodiment of the apparatus described herein includes a lock mechanism comprising a mechanical stop that is capable of limiting the rotation of the second handle leg into a maximally spread position.

Abstract: A drive system is described that uses an electric motor and a rotary angle measuring system. The measuring system shaft is supported in roller bearings in a stator which is supported relative to the electric motor in a nonrotatable fashion by means of a stator coupling. The measuring system shaft is rigidly mounted on the end of motor shaft. The rotary angle measuring system thus assumes support of motor shaft at the B end.

Abstract: The invention provides nucleic acid molecules which encode polypeptides having homology to proteins in the Delta family of proteins. The invention also provides vectors containing nucleic acid molecules of the invention and host cells containing the vectors.

Abstract: The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis.