Patents Represented by Attorney, Agent or Law Firm Francis O. Ginah
  • sPLA2 inhibitors
    Patent number: 6939890
    Abstract: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: September 6, 2005
    Assignee: Eli Lilly and Company
    Inventors: Richard Waltz Harper, Ho-Shen Lin, Michael Enrico Richett
  • Substituted carbazoles as inhibitors of sPLA2
    Patent number: 6933313
    Abstract: Carbazoles of formula (I) with R2=hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: August 23, 2005
    Assignee: Eli Lilly and Company
    Inventors: Richard Waltz Harper, Ho-Shen Lin, Michael Enrico Richett
  • sPLA2 inhibitors
    Patent number: 6930123
    Abstract: A novel class of benz[f]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: August 16, 2005
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, Michael Dean Kinnick, Ho-Shen Lin, John Michael Morin, Michael Enrico Richett, Daniel Jon Sall, Jason Scott Sawyer, Edward C R Smith
  • Spla2 inhibitors
    Patent number: 6916840
    Abstract: A novel class of benz[g]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: July 12, 2005
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, Michael Dean Kinnick, Ho-Shen Lin, John Michael Morin, Jr., Michael Enrico Richett, Daniel Jon Sall, Jason Scott Sawyer, Edward C R Smith
  • sPLA2 inhibitors
    Patent number: 6872743
    Abstract: A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: March 29, 2005
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, Michael Dean Kinnick, Ho-Shen Lin, John Michael Morin, Jr., Michael Enrico Richett, Daniel Jon Sall, Jason Scott Sawyer
  • Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors
    Patent number: 6831095
    Abstract: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: December 14, 2004
    Assignee: Eli Lilly and Company
    Inventors: Richard Waltz Harper, Ho-Shen Lin, Michael Enrico Richett
  • sPLA2 inhibitors
    Patent number: 6730694
    Abstract: A class of novel substituted pyrrole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: May 4, 2004
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, John Michael Morin, Jr., Jason Scott Sawyer, Edward C R Smith
  • spla2 inhibitors
    Patent number: 6713505
    Abstract: A class of novel benzo(b)thiophene is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: March 30, 2004
    Assignee: Eli Lilly and Company
    Inventors: Michael Dean Kinnick, Ho-Shen Lin, Michael John Martinelli, John Michael Morin, Michael Enrico Richett
  • Substituted tricyclics
    Patent number: 6713645
    Abstract: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: March 30, 2004
    Assignee: Eli Lilly and Company
    Inventors: Nicholas James Bach, Susan Elizabeth Draheim, Robert Delane Dillard, Edward David Mihelich, Jason Scott Sawyer, Douglas Wade Beight, Michael LeRoy Phillips, Tulio Suarez, Daniel Jon Sall, Jolie Anne Bastian, Michael Lyle Denney, Gary Alan Hite, Michael Dean Kinnick, Robert Theodore Vasileff, John Michael Morin, Jr., Ho-Shen Lin, Michael Enrico Richett, Richard Waltz Harper, John McNeill McGill, III, Benjamin Alan Anderson, Nancy Kay Harn, Richard James Loncharich, Richard Walter Schevitz
  • sPLA2 inhibitors
    Patent number: 6706752
    Abstract: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 medicated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: March 16, 2004
    Assignee: Eli Lilly and Company
    Inventors: Ho-Shen Lin, Michael Enrico Richett
  • sPLA2 inhibitors
    Patent number: 6635670
    Abstract: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: October 21, 2003
    Assignee: Eli Lilly and Company
    Inventors: Ho-Shen Lin, Michael Enrico Richett
  • Process for preparing a 10,11-methanodibenzosuberane derivative
    Patent number: 6624304
    Abstract: This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: September 23, 2003
    Assignee: Eli Lilly and Company
    Inventors: Bret Anthony Astleford, Charles Jackson Barnett, Michael Edward Kobierski, Thomas Michael Wilson
  • Hypoglycemic N,N-arylsulfonylglycine compounds
    Patent number: 6617343
    Abstract: A compound of formula l: wherein, R1, R2 and R3 independently represent hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl groups having 1 to 8 carbon atoms; X represents an alkoxyalkyl, alkoxyaryl, alkoxyalkylaryl, aralkylalkoxy, or alkoxyalkylheterocycle; or a pharmaceutically acceptable salt or prodrug thereof.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: September 9, 2003
    Assignee: Eli Lilly and Company
    Inventor: Samuel James Dominianni
  • Hypoglycemic sulfonyl pyrazolones and pyrazolines
    Patent number: 6617342
    Abstract: This invention provides compounds and their pharmaceutically acceptable salts, pharmaceutical formulation of said compounds and methods for treating hyperglycemia associated with non-insulin dependant diabetes and for treating hyperlipidemia.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: September 9, 2003
    Assignee: Eli Lilly and Company
    Inventor: Samuel James Dominianni
  • Process for preparing toluenesulfinates
    Patent number: 6617460
    Abstract: A process for preparing novel compounds useful in the preparation of 1H-indole-3-glyoxamides.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: September 9, 2003
    Assignee: Eli Lilly and Company
    Inventors: Benjamin Alan Anderson, Nancy Kay Harn, Richard Duane Miller, Edward Francis Plocharczyk
  • Process for preparing toluenesulfinates
    Patent number: 6570023
    Abstract: A process for preparing novel compounds useful in the preparation of 1H-indole-3-glyoxamides.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: May 27, 2003
    Assignee: Eli Lilly and Company
    Inventors: Benjamin Alan Anderson, Nancy Kay Harn, Richard Duane Miller, Edward Francis Plocharczyk
  • Process for preparing a 10,11-methanodibenzosuberane derivative
    Patent number: 6570016
    Abstract: This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: May 27, 2003
    Assignee: Eli Lilly and Company
    Inventors: Bret Anthony Astleford, Charles Jackson Barnett, Michael Edward Kobierski, Thomas Michael Wilson
  • Hypoglycemic and hypolipidemic compounds
    Patent number: 6541497
    Abstract: This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: April 1, 2003
    Assignee: Eli Lilly and Company
    Inventors: Samuel James Dominianni, Margaret Mary Faul, Russell Dean Stucky, Leonard Larry Winneroski, Jr.
  • Process for preparing 10,11-methanobenzosuberane derivatives
    Patent number: 6521755
    Abstract: This invention provides a process to prepare 10,11-(optionally substituted)methanodibenzosuberane derivatives. The invention also provides an intermediate in this process.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: February 18, 2003
    Assignee: Eli Lilly and Company
    Inventors: Bret Eugene Huff, Michael Edward LeTourneau, Thomas Michael Wilson, Julie Kay Bush, Susan Marie Reutzel-Edens
  • Chromogenic compound
    Patent number: 6448422
    Abstract: This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: September 10, 2002
    Assignee: Eli Lilly and Company
    Inventors: Patrick Irving Eacho, Patricia Sue Foxworthy-Mason, Richard Waltz Harper, Ho-Shen Lin, Jose Eduardo Lopez, Michael Enrico Richett