Abstract: A class of tricycles is disclosed together with the use of such for inhibiting Spla2 mediated release of fatty acids for the treatment of conditions such as septic shock.
Abstract: A process for preparing 4-hydroxy carbazoles useful as intermediates for preparing compounds that are useful for inhibiting sPLA2 and novel intermediates.
Abstract: A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.
Type:
Grant
Filed:
March 19, 2001
Date of Patent:
April 30, 2002
Assignee:
Eli Lilly and Company
Inventors:
Benjamin Alan Anderson, Nancy Kay Harn, Richard Duane Miller, Edward Francis Plocharczyk
Abstract: This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
Type:
Grant
Filed:
March 3, 2000
Date of Patent:
March 5, 2002
Assignee:
Eli Lilly and Company
Inventors:
Samuel James Dominianni, Margaret Mary Faul, Russell Dean Stucky, Leonard Larry Winneroski, Jr.
Abstract: A class of novel phenyl acetamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
Type:
Grant
Filed:
November 24, 1997
Date of Patent:
March 5, 2002
Assignee:
Eli Lilly and Company
Inventors:
Theodore Goodson, Jr., Richard Waltz Harper, David Kent Herron
Abstract: A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.
Abstract: This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
Type:
Grant
Filed:
December 18, 1998
Date of Patent:
February 27, 2001
Assignee:
Eli Lilly and Company
Inventors:
Samuel James Dominianni, Margaret Mary Faul, Russell Dean Stucky, Leonard Larry Winneroski, Jr.
Abstract: This invention provides 1,2,3,4-tetrahydroisoquinoline compounds and their pharmaceuticallyacceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
Type:
Grant
Filed:
December 18, 1998
Date of Patent:
September 19, 2000
Assignee:
Eli Lilly and Company
Inventors:
Samuel James Dominianni, William Harlan Gritton