Abstract: The present invention relates to methods and systems for labeling, isolating, detecting, and/or enumerating a statistically significant number of biological cells, or other biological analytes of interest, present in a complex matrix sample. The isolation of a biological target of interest from a sample mixture is done by immunomagnetic separation. Upon introduction of the sample within an imaging chamber, the capture complex (biological target-magnetic capture agent) will be attracted by the magnetic field and will lay on the surface of the chamber in the focal plane of the imaging system.

Abstract: A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.

Abstract: Disclosed is a multi-beneficial topical skin care composition, and methods for its use, that can hydrate skin, increase the firmness of skin, reduce the appearance of fine lines or wrinkles on skin, and reduce the appearance of age spots on skin. The composition can include a combination of skin active ingredients comprising euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, a combination of skin moisturizing agents comprising glycerin and butyrospermum parkii, a photo stable combination of sunscreen agents providing the composition with a sun protection factor (SPF) of at least about 15, and a dermatologically acceptable vehicle which imparts a non-greasy feel when applied to skin.

Abstract: A topical skin care composition and method for its use comprising Codium tomentosum extract and Crithmum maritimum extract, wherein the composition is formulated as an emulsion, cream, lotion, solution, gel, ointment, or anhydrous base.

Abstract: The invention relates to a method for producing an optical article having antireflection or reflective properties and comprising a substrate having at least one main surface, comprising the step of depositing an sub-layer onto a substrate's main surface, the step of treating the sub-layer by ionic bombardment and the step of depositing onto said sub-layer a multilayered stack comprising at least one high refractive index layer and at least one low refractive index layer. According to a preferred embodiment, the deposition of the sub-layer is conducted in a vacuum chamber in which a gas is supplied during the deposition step.

Abstract: Azelaic acid or its derivatives or analogs induce a robust and a speedier defense response against pathogens in plants. Azelaic acid treatment alone does not induce many of the known defense-related genes but activates a plant's defense signaling upon pathogen exposure.

Abstract: A preferred embodiment of the present invention comprises a mobile cantilever transfer device for transferring mobility-impaired patients. In one embodiment, the mobile cantilever transfer device includes a support surface that is cantilevered from a lift cart so that the support surface may be positioned over the origination or destination location for a transfer, such as a patient's bed. In yet another embodiment, the cantilevered support surface may be laterally extended from the lift cart in order to allow the support surface to be positioned at different points over a transfer location without moving the lift cart. In yet another embodiment, multiple sides of the support surface may be connected to the lift cart so that a transfer can be accomplished from multiple directions, such as on either side of a patient's bed.

Abstract: The present invention provides nucleic acid based polymerase inhibitors and methods for reducing non-specific polymerase extension and amplification in nucleic acid amplification reactions. The polymerase inhibitors provide a double stranded nucleic acid portion that is recognized by a polymerase enzyme as a template for extension but is incapable of being extended by the polymerase enzyme. The polymerase binds to the polymerase inhibitor which sequesters the enzyme until the temperature achieves a level that denatures the double stranded portion of the inhibitor after which the polymerase is released and can then catalyze nucleic acid extension.

Abstract: The invention relates to methods and apparatuses for the subterranean injection of reactive substances like propellants into wellbores and subterranean reservoirs. These methods and apparatuses controls the temperature of a reactive substance for safe handling at surface and controls the decomposition rate of the substances in the subterranean environment. In addition, these methods and apparatuses provide a means for safe dilution of reactive fluids in the event of a leak or spillage of the reactive substance.

Abstract: A method for treating an ophthalmic lens comprising two main sides, wherein at least one side comprises an organic or mineral external layer coated with a MgF2 temporary protective layer, said method comprising the specific treating step of depositing the MgF2 temporary protective layer on the external layer through vacuum evaporation at a speed lower than or equal to 0.5 nm/s. The lens obtained from the above method is capable of being submitted to a trimming operation within 48 hours after the ophthalmic lens has been treated, i.e. after the various layers have been deposited.

Abstract: Methods and devices are disclosed for providing therapeutic hypothermia using irrigation of the aerodigestive tract with cooled liquids. The disclosed method provides much more rapid therapeutic cooling to lower temperatures than could previously be achieved, thereby improving clinical outcomes. Novel cooling liquids and cooling devices are disclosed for carrying out the method. An external turbulent flow of cooling liquid may also be applied to the exterior of the head to further promote heat exchange. Multiple embodiments of devices are disclosed for performing rapid induction and maintenance of therapeutic hypothermia either in a hospital setting or in the field so that hypothermic treatment can be quickly instituted before significant tissue damage occurs. Methods are also disclosed for targeting brain cooling by irrigating the upper airway/aerodigestive tract, and more generalized cooling by irrigating the esophagus and/or stomach.

Abstract: Bone-penetrating needles for delivering a quantity of fluid to bone marrow of a bone or providing access to remove fluids from a target site is provided. The bone penetrating needles each includes at least one side port disposed at an angle away from the direction of rotation. Some of the bone penetrating needles are operable to attach to a cartridge assembly.

Abstract: There are disclosed systems and methods which provide for an inter-action between unrelated databases such that information provided to a first database by a first provider can be pushed from the first database to a user based, at least in part, on data provided by that user to a second database unrelated to the first database. This then allows a user to have information pushed to him/her based upon information previously obtained from that user or about that user. In one embodiment, the user enters his/her information into one or more databases and the entered information forms the basis for information to be pushed to that user from any database even if the pushed information resides in a non-related database. In another embodiment, the data required from a provider is determined based upon data gathered from other providers for similar items. In some situations certain data is gathered without active participation from the provider.

Abstract: Methods and systems for determining composition and completion of an experiment are provided. One-computer-implemented method for determining composition and completion of an experiment includes determining one or more characteristics of data acquired during the experiment and determining if the experiment is completed based on the one or more characteristics. One system configured to determine composition and completion of an experiment includes a processor configured to determine one or more characteristics of data acquired during the experiment and to determine if the experiment is completed based on the one or more characteristics. Another system configured to perform an experiment includes a measurement subsystem configured to acquire data during the experiment and a processor configured to determine one or more characteristics of the data during the experiment and to determine the composition of the experiment and if the experiment is completed based on the one or more characteristics.

Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Methods of reducing triglycerides or reducing C-reactive protein levels are also provided.

Abstract: Systems and methods which provide a multimode tuner architecture implementing direct frequency conversion are shown. Embodiments provide a highly integrated configuration wherein low noise amplifier, tuner, analog and digital channel filter, and analog demodulator functionality are provided in a single integrated circuit. A LNA of embodiments implements a multi-path configuration with seamless switching to provide desired gain control while meeting noise and linearity design parameters. Embodiments of the invention implement in-phase and quadrature (IQ) equalization and a multimode channelization filter architecture to facilitate the use of direct frequency conversion. Embodiments implement spur avoidance techniques for improving tuner system operation and output using a clock signal generation architecture in which a system clock, sampling clock frequencies, local oscillator (LO) reference clock frequencies, and/or the like are dynamically movable.

Abstract: The invention relates to an article having a nanotextured surface with superhydrophobic properties, comprising an array of vertical tabs, preferably regular, wherein the pillar array fulfils the following conditions: the surface fraction of the pillars Øs is such that 3%?Øs?13%, preferably 5%?Øs?12%, preferably 5%?Øs?13%, even better 5.5%?Øs?13%, even better 6%?Øs?13%, and better still 8%?Øs?13%; the pitch p of the array is such that 100 nm?p?250 nm; the height h of the pillars is such that 100 nm?h?400 nm, preferably 250?h?400 nm, even better 300?h?400 nm; and the lateral surface of the pillars is inclined at most by an angle of ±20°, preferably ±10° or even better ±5°, in relation to the vertical axis of the pillars.

Abstract: Compositions comprising a nitrite salt, a nitrate salt, and ascorbic acid are provided in several embodiments. Use of said composition in a method of enhancing cardiovascular performance or treating adverse cardiovascular event in a mammal is also provided.

Abstract: The invention relates to a polymerisable liquid mixture comprising: (a) a polymerisable thermosetting composition which is a precursor by polymerization of a first thermoset polymer material, said composition containing at least one polythiol and/or one polyol, preferably a polythiol, and at least one polyiso(thio)cyanate; and (b) a second polymer material solubilized in the aforementioned polymerisable thermosetting composition, whereby the second material (i) contains at least one block copolymer comprising at least two polymer blocks A and B, namely an elastomer block A and a hydrophilic block B, and, following polymerization of the polymerisable mixture, (ii) forms domains which are rich in elastomer block A and which are dispersed throughout the first material, said domains being smaller than 80 nanometers and preferably smaller than 50 nanometers.