Abstract: In a hot pressing apparatus, a hot-plate pressing cylinder is provided at the center of a moving plate, and a substantially central part of each of the materials to be laminated between hot plates, which are pressed by a fixed plate and a moving plate, is pressed by a hot-plate pressing cylinder of the moving plate. Thus, a uniform pressure can be applied to the materials to be laminated, thereby preventing the occurrence of defects such as wrinkles and bubbles in the products.

Abstract: The present invention relates to a composition for use as an immunomodulator comprising small molecular weight components of less than 3000 daltons, and having the following properties: a) is extractable from bile of animals; b) is capable of stimulating monocytes and macrophages in vitro and in vivo; c) is capable of modulating tumor necrosis factor production; d) contains no measurable IL-1&agr;, IL-1&bgr;, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-&ggr;; e) has an anti-proliferative effect in a malignant mouse hybridoma cell line; f) shows no cytotoxicity to human peripheral blood mononuclear cells or lymphocytes; and g) is not an endotoxin. The invention also relates to a method of preparing the composition, its use as an immunomodulator, and its use in the treatment of diseases and conditions having an immunological component.

Abstract: Disclosed are a recombinant vector for use in gene therapy for insulin-dependent diabetes mellitus and a therapeutic composition thereof. Following the injection of a &bgr;-galactosidase expression vector having a K14 promoter gene, along with a Drosophola's P transposase expression helper vector, into murine skin in a liposome-mediated manner, the &bgr;-galactosidase gene is expressed in the keratinocyte layer from 24 hours to 20 weeks after injection as measured by X-gal staining. With the enhancement effect and tissue specificity, the K14 promoter is applied for the expression of a human insulin gene in keratinocytes, thereby suggesting a new gene therapy method for treating insulin-dependent diabetes mellitus. When, in combination with the P-element expression helper vector, a human insulin expression vector with the K14 promoter is injected into the skin of diabetic mice, which lack insulin-producing &bgr;-cells of the pancreas, their blood glucose levels are maintained in a normal range.

Abstract: Centrifugal thrower-crusher device for arid matter and other materials having a revolvable inertia wheel (1) and mallets (2) diametrally matched on at least one face of the wheel inside a housing (3) with a front opening (8) at the side in which the mallets (2) are housed in a peripheral channel (17), while in the periphery another opening is defined (9), through which the materials leave thrown selectively in a centrifugal projection.

Abstract: A novel silicone gum and the use of a silicone gum such as diphenyldimethicone dissolved in a silicone oil for making a cosmetic of pharmaceutical compositions, particularly dermatological compositions, containing a fatty phase. Anb exemplary silicone oil is phenyltrimethicone. Also contemplated is the preparation of a cosmetic or pharmaceutical composition for skin care, in particular for the face or the body or for hair care.

Abstract: A fastening device and method for fastening at least two objects, such as bone portions, together in a desired alignment. The fastening device includes a securing member, such as a bone screw (10), having a head (11), a shank (12), and an end region (14) distal the head (11). The device also includes a guiding means, such as guidewire (20), comprising at least an elongate member. The guidewire (20) is connected to or formed integral with the end region (14) of the securing member (10). The device and method is especially useful in circumstances where it is desirable or, in fact, crucial for the objects to be so fastened in a particular and/or specific alignment. The device is also beneficial for use in fastening together any or all portions of bone surrounding a fracture site.

Abstract: Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include antisense oligonucleotides complementary to regions of the mammalian ribonucleotide reductase genes.

Abstract: A novel rapid-melt, semi-solid molded composition, including methods of making the same, and methods of using the same for the delivery of prophylactic and therapeutic active materials to a mammal wherein the prophylactic or therapeutic active is a psychotropic, a gastrointestinal therapeutic or a migraine therapeutic.

Abstract: This invention is about the identification of the HD-2, a natural chemical substance that was separated and purified from a natural product, Sinsuk, as arsenic hexoxide (As4O6) and about its therapeutic efficacy as an anti-cancer drug and pharmaceutical composition. Arsenic hexoxide (As4O6), a natural chemical substance obtained from Sinsuk after eliminating the toxic property, has a potent anti-cancer efficacy by its direct cytotoxicity on tumor cells and suppresses the formation of new blood vessels of tumor masses, which results in complete cure of malignant cancers.

Abstract: An insulating lining that is used as a floor covering and is especially useful in providing acoustic insulation. The insulating lining consists of a covering layer and a cell layer with a plurality of cells. The cells are defined by lateral cell walls and are open on the bearing surface side. The cell walls of the cell layer have spacers on the bearing surface side so that when the insulating covering is in place air which is enclosed in each cell can communicate directly with the airspace in each adjacent cell through a lateral space between the bearing surface and the bottom edge of the cell wall between each pair of adjacent cells.

Abstract: In a tape cassette having sensor optical path holes provided on respective wall portions on a straight line coupling a position of a light emission element with a position of a light reception element so that light from the light emission element is introduced into a tape container and light passing through a tape running path of the tape container comes out of the tape container and reaches a light reception element, a light shielding member having a light shielding effect is bonded around a sensor optical path hole right after the light from the light emission element comes out of the tape container.

Abstract: A print medium feed device and a stencil printing machine employing the same are disclosed wherein a print medium as a print sheet, transferred with a pair of secondary paper feed rollers, is transferred through a pair of transfer guide members to a press drum by which transfer of the print medium is succeeded. An upper transfer guide member, with which the print medium is brought into sliding contact, is periodically shifted between a guide position to allow the print medium to be guided to the press drum, and an inoperative non-guide position in which the upper transfer guide member is separated from the other transfer guide member. A shaft of one secondary paper feed roller is exerted with a rotational braking effect by a torque limiter, whose rotational braking effect is periodically released by a clutch unit.

Abstract: In a method for measuring a rotary tool use is made of a measuring device, which has an optoelectronic image acquisition device with optics alignable with the rotary tool and an image processing device for the computer-aided evaluation of acquired images. For measurement purposes a section of the rotary tool is brought into the image area of the optics and the rotary tool is rotated about its rotation axis. During rotation a sequence of frames of the rotating rotary tool is acquired. An evaluation of the frames is carried out with respect to at least one image parameter, which represents a measure for the positioning of the tool contour relative to the sharpness zone of the optics. By computer-aided selection a selection is made of the particular frame in which the image parameter corresponds to a positioning of the tool contour in the sharpness zone of the optics. This selected frame is used for determining at least one tool parameter characterizing the tool contour.

Abstract: The present invention relates to a device for adjusting the height of a plurality of tool carriers connected to a top panel of a bending press, each tool carrier having a tool spacer, the adjustment device comprising, for each tool carrier, an adjustment wedge interposed between the square of the top panel and the top face of the tool spacer associated with said wedge. According to the invention, the ends of each wedge include engagement mechanism to enable a wedge associated with a tool spacer firstly to overlap at least part of the top face of an adjacent tool spacer, and secondly to engage reversibly with the wedge associated with said adjacent tool spacer so that the two adjacent tool spacers touch each other, and the square of the top panel is designed to bear against the engagement mechanism.

Abstract: A two dimensional beam deflector is disclosed which deflects beams from multiple optical assemblies. The input of beams of the multiple optical assemblies follow parallel optical paths until deflection to a wafer. An ellipsometer using a two-dimensional beam deflector is also disclosed.