Patents Represented by Attorney Geoffrey G. Dellenbaugh

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  • Monoclonal antibody to human suppressor T cells
    Patent number: 4709015
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: November 24, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
    Patent number: 4695569
    Abstract: Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
    Type: Grant
    Filed: October 12, 1987
    Date of Patent: September 22, 1987
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frans E. Janssens, Joseph L. G. Torremans, Jozef E. Hens, Theophilus T. J. M. Van Offenwert
  • 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
    Patent number: 4695575
    Abstract: 4-[(Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: September 22, 1987
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Frans E. Janssens, Ludo E. J. Kennis, Jozef F. Hens, Joseph L. G. Torremans, Gaston S. M. Diels
  • Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigen, antibody, and methods
    Patent number: 4691010
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: September 1, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
    Patent number: 4689330
    Abstract: Novel substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines useful as anti-depressives, in the treatment of Parkinson's disease and in the treatment of diseases related with disturbed enterokinesia.
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: August 25, 1987
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frans E. Janssens, Theophilus T. J. M. Van Offenwert, Raymond A. Stokbroekx, Bernard R. Boar
  • Monoclonal antibody to human T cells
    Patent number: 4680383
    Abstract: Hybrid cell line for producing of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: July 14, 1987
    Assignee: Ortho Pharmaceutical
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
    Patent number: 4665075
    Abstract: Novel derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines which are useful agents in the treatment of warmblooded animals suffering from diseases according to the vascular bed in which excessive serotonin release occurs.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: May 12, 1987
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Josephus C. Mertens
  • Methods and compositions using monoclonal antibody to human T cells
    Patent number: 4657760
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: April 14, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody to human helper T cells
    Patent number: 4658020
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: April 14, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Complement-fixing monoclonal antibody to human T cells
    Patent number: 4658019
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: April 14, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Methods and compositions using complement fixing monoclonal antibody to human T cells
    Patent number: 4654210
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: March 31, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Derivatives of 2,2'-iminobisethanol
    Patent number: 4654362
    Abstract: Derivatives of 2,2'-iminobisethanol having useful properties in the treatment and/or the prevention of disorders of the coronary-vascular system.
    Type: Grant
    Filed: October 12, 1984
    Date of Patent: March 31, 1987
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Guy R. E. Van Lommen, Marcel F. L. De Bruyn, Marc F. J. Schroven
  • Methods and compositions using monoclonal antibody to human helper T cells
    Patent number: 4652447
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: March 24, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Water-dilutable wood-preserving liquids
    Patent number: 4648988
    Abstract: Wood-preserving liquids which are dilutable with aqueous mediums, said liquids containing a suitable solvent, a suitable solubilizer and an azole.
    Type: Grant
    Filed: October 15, 1984
    Date of Patent: March 10, 1987
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Paul C. M. Van Dijck, Theo F. M. C. Ligtvoet, Leo J. J. Van Leemput
  • Hybrid cell line for producing monoclonal antibody to human cytotoxic and suppressor T cells, antibody, and methods
    Patent number: 4637983
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human cytotoxic and suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: January 20, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patric C. Kung, Gideon Goldstein
  • Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
    Patent number: 4634704
    Abstract: Five membered heterocyclic ring containing N-(bicyclic heterocyclyl)-4-piperidinamines having histamine and serotonine antagonistic activity which compounds are useful agents in the treatment of allergic diseases.
    Type: Grant
    Filed: June 27, 1984
    Date of Patent: January 6, 1987
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Frans E. Janssens, Joseph L. G. Torremans, Jozef F. Hens, Theophilus T. J. M. Van Offenwert
  • Anti-protozoal .alpha.-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneace tonitrile derivatives, pharmaceutical compositions, and method of use therefor
    Patent number: 4631278
    Abstract: The present invention is related with .alpha.-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneaceton itriles which are effective in destructing or preventing the growth of Protozoa in subjects suffering from such Protozoa.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: December 23, 1986
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gustaaf M. Boeckx, Alfons H. M. Raeymaekers, Victor Sipido
  • Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigens, antibody, and methods
    Patent number: 4624925
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: November 25, 1986
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-diox olan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4619931
    Abstract: Substituted [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H -imidazoles and 1H-1,2,4-triazoles having antimicrobial properties and being particularly useful in the treatment of vaginal candidosis.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: October 28, 1986
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Leo J. J. Backx
  • Hybrid cell line for producing monoclonal antibody to a human T cell antigen, antibody, and methods
    Patent number: 4614720
    Abstract: Hybrid cell line for production of monocloral antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: September 30, 1986
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein