Patents Represented by Attorney Gerald D. Sharkin
  • Patent number: 5207802
    Abstract: Compounds and mixtures of compounds obtainable by condensation of sulphonation products of defined alkyl-substituted naphthalenes and sulphonation products of optionally alkyl-substituted diphenylethers with formaldehye and optionally treated with further components, are valuable interface-active compounds suitable as assistants in various application fields, in particular as dispersing or levelling agents in the dyeing with disperse dyes or as tanning-assistants or dyeing-assistants for leather.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: May 4, 1993
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Baumann
  • Patent number: 5203919
    Abstract: Method and compositions for the stabilization (prevention of hardening) of concrete residues in Ready-Mix truck drums.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: April 20, 1993
    Assignee: Sandoz Ltd.
    Inventors: Gregory S. Bobrowski, Robert J. Ryan
  • Patent number: 5200411
    Abstract: The compounds of formula I ##STR1## wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity.They can be prepared by one or more of the following process variants: reduction, deprotection, acylation, reaction with N,N'-carbonyl- or N,N'-thiocarbonyldiimidazole, halogenation, splitting off of hydrogen halide, reaction with a hydrogen carbonate, radical deoxygenation, dehydration or reaction with diazomethane of -ethane, optionally under transient protection of reactive groups which it is not desired to react.
    Type: Grant
    Filed: June 13, 1991
    Date of Patent: April 6, 1993
    Assignee: Sandoz, Ltd.
    Inventors: Andrew J. F. Edmunds, Maximilian Grassberger
  • Patent number: 5198459
    Abstract: The invention provides use of a 5HT-3 antagonist in the manufacture of a medicament suitable for the prevention or reduction of dependence on a dependence-inducing agent.
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: March 30, 1993
    Assignee: Sandoz Ltd.
    Inventors: Assunta Imperato, Dietmar Romer
  • Patent number: 5196031
    Abstract: A process for dyeing a mixed fibrous substrate comprising applying to the substrate,a) at least one disperse dye,b) at least one copper - containing direct or reactive dye, preferably in a sufficient amount to produce a dyeing greater than a 1/1 standard depth;c) a complexing agent having a stability constant (K-value) with the metal of the direct or reactive dye of from 6 to 17 inclusive;d) a lignin sulphonate dispersing agent; ande) an oxidizing agent capable of converting copper (I) to copper (II) at a temperature of 100.degree.-130.degree. C. at a pH of 5-7 in the process for dyeing the mixed substrate.
    Type: Grant
    Filed: August 27, 1991
    Date of Patent: March 23, 1993
    Assignee: Sandoz Ltd.
    Inventor: John A. Hook
  • Patent number: 5196032
    Abstract: 1. A process comprisinga) a two liquor process for treating a cellulosic substrate with alkali and applying a dye to the substrate characterized by pad treating the substrate with alkali and dyeing by pad dyeing or printing with a reactive dyestuff without an intermediate washing step; orb) a one liquor process for treating a cellulosic substrate with alkali and a dye characterized in that the substrate is pad treated with alkali and reactive dye.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: March 23, 1993
    Assignee: Sandoz Ltd.
    Inventor: Christian Oschatz
  • Patent number: 5192341
    Abstract: In an operation wherein a gaseous stream, such as an air stream, is contacted with a liquid selective solvent for a component of the gaseous stream for the removal of said component from the gaseous stream, improved results are obtain, particularly in a direct gas-liquid countercurrent contacting operation, by employing a liquid selective solvent which has a viscosity of less than about 30 centipoises at 77.degree. F. Suitable such solvents include diethyl phthalate, dioctyl phthalate, dioctyl adipate, acetyltributyl citrate and diisohexyl phthalate, particularly blends or mixtures thereof.
    Type: Grant
    Filed: October 25, 1991
    Date of Patent: March 9, 1993
    Assignee: Sandoz Ltd.
    Inventor: Arthur J. Ehrler
  • Patent number: 5190941
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description, are useful for the treatment of conditions associated with cerebral ischaemia, e.g. stroke.
    Type: Grant
    Filed: December 12, 1990
    Date of Patent: March 2, 1993
    Assignee: Sandoz Ltd.
    Inventors: Joachim Nozulak, Andre Sauter, Jean-Marie Vigouret
  • Patent number: 5189111
    Abstract: Water-dilutable side-chain-containing vinylic copolymers comprising groups (.gamma.) of the formula--X--Alk--Y-- (I),whereinAlk signifies alkylene with 2-6 carbon atoms or hydroxysubstituted alkylene with 3-6 carbon atoms or alkylene with 4-6 carbon atoms, interrupted by --O--,X signifies a basic amino group or an ammonium group andY signifies a basic --NH-group or an acid adduct thereof,one of X and Y being further bound to an optionally substituted aliphatic or heteroaromatic hydrocarbon radical and the other to hydrogen or an optionally substituted aliphatic hydrocarbon radical, as a constituent of a least some of the side-chains and at least one mole % of the comonomer units constituting the copolymer bearing such (.gamma.)-containing side-chains - which are obtainable by copolymerization of corresponding comonomers or by amino-alkylation of corresponding starting polymers - are particularly suitable as precipitating and/or flocculating agents, e.g.
    Type: Grant
    Filed: January 4, 1989
    Date of Patent: February 23, 1993
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • Patent number: 5188628
    Abstract: A closure device for connection to a fluid container which has an opening for receiving the device. The closure device has a base section which may sealably cover the container opening. The base section has a spike receiving opening passing there through with at least one air vent on the base section which is spaced from the spike receiving opening. A hydrophobic air filter, is associated with the air vent. Adjoining the base section is an internal cover, which lies over the aperture, covering it and the base section. The internal cover has a pierceable portion which is in alignment with the spike receiving opening of the base section.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: February 23, 1993
    Assignee: Sandoz Ltd.
    Inventors: Robert G. Rani, Douglas E. Hahn
  • Patent number: 5189164
    Abstract: A process for synthesizing syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof from the corresponding keto-hydroxy compounds, which process comprises: providing a reaction medium comprising sodium borohydride and an alkoxydialkylborane compound; treating the keto-hydroxy compound with said reaction medium under conditions wherein a cyclic boronate ester is formed; and cleaving the cyclic boronate ester to obtain the dihydroxy product.The product compounds, or derivatives thereof, are useful as anti-atherosclerotic agents.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: February 23, 1993
    Assignee: Sandoz Ltd.
    Inventors: Prasad K. Kapa, Kau-Ming Chen
  • Patent number: 5188640
    Abstract: Compound of the formula ##STR1## in which both groups --NR.sub.1 R.sub.2 are identical;R.sub.1 is C.sub.2-4 alkyl, substituted by one or two hydroxy groups and salts thereof,R.sub.2 is hydrogen, C.sub.2-4 hydroxyalkyl or --CH.sub.2 CH.sub.2 CN, provided that when R.sub.2 is --CH.sub.2 CH.sub.2 CN then R.sub.1 can only be --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH,and mixtures of such compounds, which compounds are in free acid or salt form, and are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, especially leather and textiles containing or consisting of natural or synthetic polyamides or of natural or regenerated cellulose; the most preferred substrate is textile material containing or consisting of cotton.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: February 23, 1993
    Assignee: Sandoz Ltd.
    Inventor: Hans von Tobel
  • Patent number: 5182271
    Abstract: The invention discloses certain thioether, keto-ester and alkyl phospholipids which are useful in treating multiple sclerosis.
    Type: Grant
    Filed: August 30, 1991
    Date of Patent: January 26, 1993
    Assignee: Sandoz Ltd.
    Inventor: William J. Houlihan
  • Patent number: 5182383
    Abstract: The invention relates to new stable, crystalline forms of the t-butylester of ceftazidime of formula ##STR1## and the production thereof.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: January 26, 1993
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Bernhard C. Prager, Karl Wessely, Werner Veit
  • Patent number: 5177085
    Abstract: 6,7-Di(C.sub.1-4 alkoxy)-1-[3,5-di(C.sub.1-4 alkoxy)phenyl]-3,4-dihydro-3-hydroxy-methyl-isoquinolines, their physiologically hydrolyzable and -acceptable esters and acid addition salts thereof are novel. The said compounds and esters and pharmaceutically acceptable acid addition salts thereof are useful as pharmaceuticals, e.g. in the treatment of asthma.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: January 5, 1993
    Assignee: Sandoz Ltd.
    Inventor: Reto Naef
  • Patent number: 5177059
    Abstract: Polymyxin B carrier conjugates, especially polymyxin B-dextran, are water soluble, have a greater half-life in the bloodstream and are significantly less toxic than native polymyxin B.
    Type: Grant
    Filed: November 1, 1990
    Date of Patent: January 5, 1993
    Assignee: Sandoz Ltd.
    Inventors: Dean A. Handley, Philip Lake
  • Patent number: 5176753
    Abstract: A chloride-free admixture for use as a cold weather (e.g., 13.degree. F. to 40.degree. F.) concrete set accelerator. The admixtures comprise;1) at least one soluble inorganic salt having freezing point depressant properties,2) at least one water reducing dispersant, e.g., superplasticizer,3) at least one inorganic early set and strength accelerator, and optionally,4) at least one inorganic set accelerator.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: January 5, 1993
    Inventor: John W. Brook
  • Patent number: 5175353
    Abstract: The 2-(2'-aminoethoxy)ethanol salt of dicamba is useful as a herbicidal and has the advantages of a lower volatility and excellent solubility in water and organic solvents.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: December 29, 1992
    Assignee: Sandoz Ltd.
    Inventors: Rita S. Jones, Michael T. Chirchirillo, Johnny L. Burns
  • Patent number: 5169773
    Abstract: Novel monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metabolites, e.g. Cyclosporins 17 and 18, are produced, e.g. starting from novel cyclosporins having an activated coupling group, e.g. activated carboxy group, e.g. (i) [(O-succinimidooxysuccinyl)-Thr].sup.2 -Cyclosporine and (ii) [(N-.epsilon.-succinimidooxysuccinyl)-(D)Lys].sup.8 -Cyclosporine. Cyclosporin starting materials required for the production of cyclosporins of type (ii), e.g. [(D)Lys].sup.8 -Cyclosporine are also new and additionally have utility in the preparation of novel labelled cyclosporin derivatives, as well as antibodies and antisera generally. Also claimed are novel antigenic conjugates and hybridoma cell lines used in the production of antibodies and antisera as aforesaid as well as assay kits comprising novel antisera, antibodies and/or labelled cyclosporins as aforesaid.
    Type: Grant
    Filed: October 31, 1988
    Date of Patent: December 8, 1992
    Assignee: Sandoz Ltd.
    Inventors: Joachim Rosenthaler, Roland Wenger, Philipp E. Ball, Max H. Schreier, Valerie Quesniaux
  • Patent number: RE34239
    Abstract: A semi-permeable membrane .[.which comprises.]. .Iadd.having high permeability characteristics is disclosed. This may comprise .Iaddend.either(i) a copolymer of acrylonitrile and at least one ionic or ionizable monomer, or(ii) a copolymer of acrylonitrile, at least one ionic or ionizable monomer, and at least one non-ionic and non-ionizable monomer, or(iii) a mixture of at least two copolymers as defined under (i) and/or (ii), or(iv) a mixture of at least one copolymer as defined under (i) and/or (ii), and at least one copolymer of acrylonitrile and at least one non-ionic and non-ionizable monomer, the ionic or ionizable monomer units representing from 1 to 80 mole % of the monomer units in one of said copolymers, and representing from 1 to 50 mole % of the monomer units in the membrane, said membrane having a degree of salt rejection of less than 1% and a permeability to water of more than 100 liters/day.m.sup.
    Type: Grant
    Filed: January 18, 1990
    Date of Patent: May 4, 1993
    Assignee: Hospal Ltd.
    Inventor: Xavier Marze