Abstract: A novel, stable, crystalline sodium (5R,6S,8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxyl ate (designated as Form II) is prepared by forming a homogenous solution of sodium (5R,6S,8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxyl ate combined with stirring the homogenous solution for a time and at a temperature sufficient to produce Form II and recovering Form II. Form II may also be prepared by contacting a first solution obtained by dissolving (5R,6S,8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxyl ic acid in dimethylacetamide with a second solution obtained by dissolving a sodium salt of an organic acid having a pKa of up to about 5, e.g., sodium 2-ethylhexanoate in acetone, in the presence of at least 5 volume percent water while stirring the reaction mixture so formed at a temperature and for a time sufficient to produce Form II followed by recovering Form II.

Abstract: Phosphinylalkanoyl imino acids useful in the treatment of hypertension are disclosed.

Abstract: A mascara application system features a mascara fluent having a viscosity range from 1,500 to 25,000 poises at ambient temperature; and a brush applicator having from 100 to 150 bristle strands per quarter inch of material, with a denier of approximately 0.003 to 0.004 inches. This system separates and combs the eyelashes as it simultaneously applies the mascara in an even and uniform manner.

Abstract: There is disclosed desevernitrose, acetamido, ethylamino and diethylamino derivatives of antibiotic 13-384 components 1 and 5 represented by the following formula ##STR1## wherein R is hydrogen, or ##STR2## wherein R.sup.1 is acetamide, ethylamine, diethylamine, N-hydroxylamino, nitroso or the pharmaceutically acceptable salts thereof.

Abstract: Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.

Abstract: There are disclosed 2(N-heterocyclyl) penems and their pharmaceutically acceptable salts and esters and their use as anti-bacterials.

Abstract: This invention relates to 2-(N-heterocycloaliphaticthio)penems wherein the nitrogen of the heterocyclic ring is connected to the alkyl group, and to their use as antibacterial agents.

Abstract: The compound 4,7-dimethyl-2-(4-pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidin-5(4H)-one and the pharmaceutically acceptable salts thereof are analgesic and anti-inflammatory agents. Methods for preparing and using the compound and salts are described.

Abstract: The antibiotic 13-384 complex is elaborated by a new variety of Micromonospora carbonacea; namely Micromonospora carbonacea var africana NRRL 15099.

Abstract: Antiviral (3-ethoxypropionate) esters of (+)-cyclaradine having the formula: ##STR1## In the monoester Ry and Rz are hydrogen. In the diester Ry is the 3-ethoxypropionyl group and Rz is hydrogen. In the triester, Ry and Rz are each 3-ethoxypropionyl groups.

Abstract: Disclosed is a mascara applicator whose brush contains alternating rows of long and short bristles. The alternating rows of long and short bristles allow for facile application of mascara while simultaneously combing and separating the eyelashes.

Abstract: There is disclosed 2-(arylalkyl-heterocyclylalkylthio)penems having long serum half-lives and their uses as antibacterial agents.

Abstract: Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma.

Abstract: Improved processes for the production of 6-hydroxyethyl-2-substituted thio penem-3-carboxylates which eliminate the step of using a silver reagent are disclosed.

Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.

Abstract: A method for producing bronchodilation in a mammal is disclosed. Composition for use in said method are also described.