Abstract: A method of treating interstitial cystitis is disclosed comprising administering to a patient in need thereof an effective amount of a compound selected from compound 1, its metabolite 2 and pharmaceutically acceptable salts thereof:

Abstract: This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming artificial livers.

Abstract: The invention relates to a method for the purification of a fermentatively prepared ?-hydroxy acid on an industrial scale, in which an ?-hydroxy acid with a color (fresh) of not more than 10,000 APHA units is subjected to at least two crystallization steps, with the crystallization steps being carried out in cooling crystallization devices, melting crystallization devices, evaporative crystallization devices and/or adiabatic crystallization devices.

Abstract: A scaled-up multi-coaxial fiber bioreactor, and variations of this bioreactor. The device is characterized by a hollow housing and an array of from about 20 to about 400 modules of hollow fibers, where each module includes at least three coaxial semipermeable hollow fibers. The innermost fiber provides a boundary for an innermost compartment which is connected to inlet and outlet ports. Arranged coaxially around the central hollow fiber are several other hollow fibers with their respective compartments, each compartment defined by a respective annular space between adjacent fibers and each including inlet and outlet ports. An outermost compartment for permitting integral aeration is the space between the outer side of the outermost fibers and the inner side of the housing, and has inlet and outlet ports. The hollow housing has inlet and outlet manifolds and flow distributors for each of the compartments. In a preferred embodiment the bioreactor is used as an extracorporeal liver.

Abstract: The invention relates to a method of purifying lactic acid esters, wherein an impure lactic acid ester is subjected to a melt crystallization. The impure lactic acid contains not more than 10 wt. % of impurities, based on the total amount of ester, and has a chiral purity of more than 90%. The ester is derived from lactic acid and a C1–C18 alcohol.

Abstract: A method and system for determining the effect of precipitation on flow within a sewer network includes identifying a modeled response of the sewer to a precipitation event. Once the modeled response is identified, scaled responses to future precipitation events may be predicted, in real time, by measuring intervals of the precipitation event and calculating the scaled response as a function of the modeled response and the precipitation quantity measured during the precipitation event.

Abstract: An antenna assembly is formed from at least one antenna and associated conductive connecting element (wires, conductive gel or liquid, etc.) mounted within a deformable membrane that allows the antenna assembly to be installed or fixed within a narrow gap or crevice, wherein the gap or crevice may be subject to harsh environmental conditions. The gap or crevice is preferably a gap or crevice in a closure. The antenna assembly typically has a low profile, and is installed either flush with or within a traffic surface or within ¼″ above the surface. The deformable membrane will yield under force, but return to its original shape once the force is removed. The deformable membrane and antenna assembly will deform to conform to the shape of a gap or crevice into which the antenna assembly is installed.

Abstract: This invention relates to a composition for use in treating benign prostatic hyperplasia including a saw palmetto extract provided in an oral controlled release formulation which allows release of active ingredients in the intestinal tract and which allows the maintenance of therapeutic levels of active agents in the bloodstream for prolonged periods of time. This invention also relates to a composition for improving the efficacy of a saw palmetto extract, a method of treating benign prostatic hypertrophy, and a method of improving the efficacy of a saw palmetto extract treatment.

Abstract: A method and system for monitoring and analyzing flow in a sewer system includes the steps of using a monitoring assembly to collect data representative of actual flow volume of a fluid substance in a first location such as a sewer pipe, storing the actual flow volume data in a memory, maintaining previously stored data in the memory, determining a predicted flow volume and comparing the actual flow volume with the predicted flow volume to yield a difference value. The predicted flow volume is dependent on the data selected from the previously stored data and a day and time that corresponds to both the actual flow volume data and the data selected from the previously stored data. The predicted flow volume may also be dependent upon additional data corresponding to a rain event.

Abstract: A device for storing and administering a medical fluid comprising a sealed flexible formed container with an opening part in its front end in which an insert is positioned. Over the insert, the container extends into a removable sealing cap. After removal of the sealing cap an injection means is attached to the insert and fluid administration through the insert is admitted in one direction by squeezing the container.

Abstract: This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

Abstract: The invention relates to a method for the preparation of lactic acid and calcium sulphate, in which (a) an aqueous solution that contains lactate is reacted with sulphuric acid at a temperature that is essentially higher than the transition temperature of calcium sulphate dihydrate (CaSO4.2H2O), with the formation of a mixture that contains calcium sulphate hemihydrate and lactic acid, (b) the mixture from step (a) is subjected to at least one recrystallisation step at a temperature that is essentially lower than the transition temperature of calcium sulphate dihydrate, with the formation of a precipitate of calcium sulphate dihydrate and an aqueous solution of lactic acid, and (c) the precipitate of calcium sulphate dihydrate is separated off from the aqueous solution of lactic acid.

Abstract: The present invention relates to a sun protection product which contains microparticles as the active agent, wherein the microparticles comprise water-insoluble linear polyglucan.

Abstract: A composition useful as a substitute for table salt is disclosed. The salt substitute contains calcium chloride, a potassium salt, citric acid, rice flour, ginger oil and one or more flavorants.

Abstract: This invention relates to a composition for use in treating benign prostatic hyperplasia including a saw palmetto extract provided in an oral controlled release formulation which allows release of active ingredients in the intestinal tract and which allows the maintenance of therapeutic levels of active agents in the bloodstream for prolonged periods of time. This invention also relates to a composition for improving the efficacy of a saw palmetto extract, a method of treating benign prostatic hypertrophy, and a method of improving the efficacy of a saw palmetto extract treatment.

Abstract: The invention relates to pharmaceutical closures for containers made of flexible polyolefinic materials which are suitable to be filled with parentally administrable fluids prior to their sealing and sterilization. The polyolefinic closures have an excellent resealing capacity after being penetrated by a piercing device for establishing fluid communication with the container, even after multiple entries into the container.

Abstract: The invention relates to a fuel composition which comprises a diesel fuel, a C1-C4 alkyl ester of an &agr;-hydroxymonocarboxylic acid and, if appropriate, a C1-C4 alcohol. The diesel fuel is either obtained from petroleum or from a petroleum fraction, such as middle distillate, or is obtained by conversion of material of biological origin (so-called biodiesel). The fuel composition preferably contains from 3 to 6% by weight of C1-C4 alkyl ester, calculated on the basis of the total weight of the composition.

Abstract: A composition is disclosed for alleviating or managing symptoms associated with premenstrual syndrome “PMS” comprising an effective amount of an aqueous mixture of water and a rapidly digestible carbohydrate blend. The aqueous mixture is essentially free of protein and is characterized by a certain pH and ratio of water to carbohydrate blend. Methods of use of the composition for alleviating or managing symptoms associated with PMS are also disclosed.