Abstract: A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D-A moiety is in turn covalently linked through the anomeric carbon of A to the P-R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P-R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support.

Abstract: This invention provides a novel fluorescent article comprising a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are capable of giving off multiple fluorescent emissions simultaneously, which is useful for multiplexed analysis of a plurality of analytes in a sample. The coupled complex particles carrying on their surface fluorescent nanoparticles, methods of preparing such polymer articles, and various applications and methods of using such particles are claimed.

Abstract: A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a period of time. The diploid nucleus can be donated by a cell in either the G0 or G1 phase of the cell cycle at the time of transfer. Subsequently, the reconstituted embryo is activated. Correct ploidy is maintained during activation, for example, by incubating the reconstituted embryo in the presence of a microtubule inhibitor such as nocodazole. The reconstituted embryo may then give rise to one or more live animal births. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.

Abstract: The invention relates to a method for purifying protein containing waste water, In which a) a first insoluble material is caused to form in the waste water, b) the mixture obtained in step a) is separated to form pre-purified waste water, c) the pre-purified waste water is treated with aerobic microorganisms and d) the mixture obtained in step c) is separated to form finely purified waste water, and in which step b) and step d) are carried out in the same device. Preferably, steps b) and d) are alternately carried out in the same device.

Abstract: Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.

Abstract: The present invention is directed to a cannula, attachable to an injection device comprising a needle entirely surrounded by an essentially cylindrical collapsible needle cover in order to visually hide the entire needle during the whole procedure of administration by injection. The collapsible needle cover comprises a resilient, cylindrical or vaguely conical sleeve made of a foamed polymer and is provided with an axially extended hole for the needle, alternatively the needle cover can have a bellows-like structure. Also disclosed is a method of administering a medicament by injection with needle hidden from visual impression during the whole administration process.

Abstract: An azimuth sensor unit 15 and an altitude sensor unit 16 have pairs of optical sensors 18 and 20, respectively, disposed along their respective directions, which pair of optical sensors are disposed toward the sun in the form of a tapered section narrower to the front end and broader to the rear end with their light-receiving surfaces outward, and the azimuth sensor unit and the altitude sensor unit themselves rotate so as to balance light-receiving amounts of their respective pairs of optical sensors and send signals for rotating a concave mirror 10 in the same directions by half the amounts of the rotations of the azimuth sensor unit and the altitude sensor unit to a drive mechanism.

Abstract: Optical systems are disclosed that enable an image sensor to generate an image of either a wide-angle view of an area of interest, or a direct view of an area of interest. In an embodiment, a wide-angle optical system is mounted to reflect radiation reflected from the area of interest along an optical axis. Radiation on the optical axis is directed to a zoom lens of the image sensor. Optionally, a planar mirror redirects the radiation, so that the optical axis is angled with respect to a central axis of the image sensor. In the preferred embodiment, the image sensor is a pan-tilt-zoom camera that can move from the wide-angle view to a direct view of a target or region of interest, using pan, tilt, and zoom controls, under either remote or automatic control. The disclosure also provides a method for maintaining registration of the image sensor when it is moved from a wide-angle view of a target to a direct view of a target.

Abstract: A portable computer apparatus for assisting a cognitively impaired person to perform tasks in the person's particular living environment is disclosed. The portable computer apparatus presents a plurality of first level virtual buttons on a display for selection by the person. Each first level virtual button corresponds to a different selectable domain or selection type. The first level virtual buttons are configured to correspond to the abilities and life needs of a particular person. When selected, a first level virtual button causes a category, sub-category, task, task element or content element to be presented. A hierarchical content structure, custom-tailored to the life needs and abilities of the particular cognitively impaired individual is provided. A means is provided, by an authoring facility hosted on a separate PC, to develop the user's content and download it to the portable computer apparatus.

Abstract: Disclosed are methods and means for facilitating injection which enable a correct penetration depth of the needle.

Abstract: A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P—R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D—A moiety is in turn covalently linked through the anomeric carbon of A to the P—R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P—R groups used in assembling the compounds.

Abstract: The present invention discloses a new vaccine composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.

Abstract: The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. SLPs and PBAs are prepared by the following emulsification process: (1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted.

Abstract: A pharmaceutical composition including tannic acid and tannin complexes, and a method of treating cancer with tannic acid and tannin complexes.

Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g.

Abstract: The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage of the discovery that the relative reactivity of glycoside residues containing anomeric sulfoxides and nucleophilic functional groups can be controlled. In another aspect of the invention, the reactivity of activated anomeric sugar sulfoxides is utilized in a solid phase method for the formation of glycosidic linkages. The methods disclosed may be applied to the preparation of specific oligosaccharides and other glycoconjugates, as well as to the preparation of glycosidic libraries comprising mixtures of various oligosaccharides, including glycoconjugates, which can be screened for biological activity.

Abstract: A data management system user interface allows users to enter, store, retrieve, and display multiple, related groups of information in a single document. The interface loads document data into a separate template which defines various fields, and the interface determines the fields that should be displayed based on the information entered by the user. The user enters an unlimited amount of data into each field, thus creating a free-flowing document, and the user can create groups of entries for each field. The interface also contains a data validation and error correction feature, that provides automatic correction, prompts for manual correction, and allows the user to save a draft document with a list of errors for future correction at a later date.

Abstract: A new and distinct variety of peach Prunus persica tree with the following combination of unique features that are desirable in a new variety. 1. Heavy and regular production of fruit. 2. Production of very firm, white flesh fruit with good handling and shipping quality. 3. Fruit that will stay firm on the tree 10 to 17 days after maturity (shipping ripe). 4. Fruit with excellent flavor and eating quality. 5. Middle season maturity of white flesh fruit. 6. Fruit having a skin with pink overspread with light yellow. 7. Vigorous half-open growth.

Abstract: A new and distinct variety of peach Prunus persica tree with the following combination of unique features that are desirable in a new variety. 1. Heavy and regular production of fruit. 2. Production of very firm, white flesh fruit with good handling and shipping quality. 3. Fruit that will stay firm on the tree 10 to 13 days after maturity (shipping ripe). 4. Fruit with excellent flavor and eating quality. 5. Middle season maturity of white flesh fruit. 6. Fruit skin pink overspread with light yellow. 7. Vigorous half-open growth.

Abstract: A new and distinct variety of peach ‘Prunus persica’ tree with the following combination of unique features that are desirable in a new variety. 1. Heavy and rugular production of fruit. 2. Production of very firm, white flesh fruit with good handling and shipping quality. 3. Fruit that will stay firm on the tree 15 to 17 days after maturity (shipping ripe). 4. Fruit with excellent flavor and eating quality. 5. Early season maturity of white flesh fruit. 6. Fruit with an attractive red skin. 7. Vigorous half-open growth.