Abstract: Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.

Abstract: This invention relates to oligonucleotides complementary to the neuropilin genes which modulate tumor cell growth and angiogenesis in mammals. This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells and angiogenesis in mammals. This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.

Abstract: An apparatus, system and method for providing spot lighting for observing a gemstone is presented. In particular, the spot lighting provided by the invention allows for observing of the fire of a gemstone, i.e. the visible effects of light dispersion into separate colors. The apparatus includes a tube for receiving a portion of a multi-spectral light source, and a mask coupled to the tube for blocking other portions of the light source. By selecting the proper tube dimensions and aligning the tube with both the light source at an inlet and a gemstone at an outlet, the spot lighting source provides direct lighting for isolating and accentuating the effects of fire.

Abstract: A method of determining an energy load on a power distribution component, and a system for storing such method are presented. The method entails collecting meter data (in various formats) and weather data. The meter data and the weather data are correlated to generate tuning equations, each of which is associated with at least one of the meters and indicates a weather sensitivity of that meter. Any meter data that is in the hourly or daily format are normalized to generate normalized hourly loadshapes that are independent of weather conditions and weekly variations. These normalized hourly loadshapes are combined with the tuning equations to generate a set of model coefficients for each of the meters. The set of model coefficients reflects weather conditions and weekly variations for one of the meters, and is useful for determining an energy load on the power distribution component.

Abstract: The present invention relates to an organic electroluminescence display using a metallocene compound, and more particularly to an organic electroluminescence display with a simple structure using a metallocene compound, which has superior photoconductivity, can be used as a p-type semiconductor material, and functions as a superior luminescent material, as a luminescent material.

Abstract: The liquid crystal display device having a mirror function includes a back light assembly, a liquid crystal display panel, a first polarizing plate, a selective reflection polarizing plate and a second polarizing plate. The back light assembly generates a light. The liquid crystal display panel includes an upper substrate, a lower substrate facing the upper substrate, and a liquid crystal layer interposes between the upper substrate and the lower substrate. The liquid crystal display panel receives the light generated from the back light assembly to generate an image. The first polarizing plate is disposed on the upper substrate. The selective reflection polarizing plate is disposed on the first polarizing plate. The selective reflection polarizing plate selectively reflects an external light. The second polarizing plate is disposed on the lower substrate.

Abstract: A hand-held ink stamper has a base, an actuator slidably disposed on the base, and a die mount movably mounted within the base. The die mount is connected to the actuator and movable to at least a printing position upon movement of the actuator. A die is mounted on the die mount. A first, removable ink supply is mounted within the base at a first position and provides ink to the die. At least one second, spare, removable ink supply is stored within the base at a second position. The second ink supply is removable for replacing the first ink supply by moving the second ink supply to the first position.

Abstract: The invention provides cells and methods for identifying modulators of signal transduction, based on transducisome proteins that coordinate and assemble many types of signal transduction proteins. A transducisome is a PDZ domain containing protein that binds at least one signal transduction protein or a PDZ domain containing protein with at least one signal transduction protein bound. Examples of transducisome proteins include INAD, GRIP and other recently identified multi-PDZ domain proteins. Examples of signal transduction proteins include GPCRs, tyrosine kinase receptors, tyrosine phosphatase receptors, ion channels, phospholipases, adenylate cyclases, kinases and G-proteins. Also provided are methods for identifying modulators of signal transduction, proteins (and polynucleotides encoding the same) corresponding to transducisomes, modified transducisomes or defective transducisomes to use in assays of signal transduction, and a screening assay system for detecting protein-protein interactions.

Abstract: A children's vehicle features a main frame member with a seat support member attached thereto. A generally horizontal plate is attached to the seat support member and features a central portion with a number of transverse ridges. Slots are formed in the plate on opposing sides of the central portion. The seat features a number of ridges formed on its bottom surface as well as a pair of bolt holes. Bolts pass through the seat bolt holes and the slots of the plate. Knobs engage the bottoms of the bolts and may be loosened to permit the seat to be moved relative to the plate and tightened so that the ridges of the seat engage the ridges of the plate to lock the seat in a selected position.

Abstract: The invention is a grounding device that grounds the wearer when the wearer is in a designated area and automatically disengages when the wearer leaves the designated area. In more detail, the grounding device includes a wristband that is electrically coupled to a grounded object with a fastening mechanism, wherein the fastening mechanism automatically releases to separate the wristband from the grounded object if the wristband is outside of the designated area. Where the fastening mechanism includes a coupling mechanism (e.g., a wire), there may be a rotating device that retracts the coupling mechanism after the fastening mechanism is released. The device may be enhanced with a grounding device monitoring unit that monitors whether the grounding device is in use and a sensor that detects whether the operator is in the designated area, so that an alarm is triggered if the operator is in the designated area and the grounding device is not in use.

Abstract: A semiconductor memory device and method for making the same, where a memory cell and high voltage MOS transistor are formed on the same substrate. An insulating layer is formed having a first portion that insulates the control and floating gates of the memory cell from each other, and a second portion that insulates the poly gate from the substrate in the MOS transistor. The insulating layer is formed so that its first portion has a smaller thickness than that of its second portion.

Abstract: A circular saw includes a worktable, a blade supporting unit pivotally mounted to the worktable, a saw blade shaft mounted rotatably on the supporting unit and driven by a motor to rotate a saw blade, a driving shaft mounted rotatably on the supporting unit, and a dust collecting member confining a dust passageway which has an intake port in the vicinity of the saw blade, and an outlet port for passage of wood dust. A blower casing is disposed outwardly of the supporting unit, and defines an accommodation chamber disposed downstream of the outlet port and receiving a driving end of the driving shaft. An impeller is mounted on the driving end and is rotatable so as to draw wood dust from the dust passageway into the accommodation chamber and out through a discharge port.

Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.

Abstract: A structural cell system is disclosed for supporting hardscape areas in a way that enables tree root growth and accommodates filtering, retention, storage and infiltration of storm water while preventing hardscape damage. The system includes a plurality of structural cells capable of being positioned below a hardscape. The structural cells are designed to have openings that are sized to accept tree roots. The system has one or more permeable barriers around the structural cells with a way for water to flow into the plurality of structural cells flow out of the structural cells.

Abstract: An automated method for treating tinnitus by habituation through use of neurological feedback, comprising the steps of connecting a subject through a set of attached headphones to an electronic sound player that is connected to a PC workstation presenting sound examples by software to the subject who can refine them by manipulating a series of controllers on the player, making an electronic recording of the sound in a digital music format, storing the recording in the computer, transferring a copy of the electronic sound file to the subject's electronic music player, generating an EEC signature of the subject's brain activity in response to the presented sound, sound using the customized sound to stimulate the auditory system while the brain activity is recorded, wherein the computer continuously monitors for the feedback signatures and drives the sound stimuli appropriately.

Abstract: This invention relates to a method for manufacturing a large FRP member including: disposing a preform containing a reinforcing fiber on a surface of a molding die; covering a molding portion with a bagging material or a mold and providing a suction port and a resin injection port for sealing; evacuating the molding portion through the suction port; heating the molding portion; injecting a thermosetting resin from the resin injection port for impregnating the reinforcing fiber with the resin while a temperature Tm of the molding die and a temperature Tv of the bagging material or the mold are both set to room temperature or more, and a difference ?T in temperature between the Tm and the Tv is set to 10° C. or less; and curing the resin by maintaining the molding portion at a predetermined temperature Tpc which is equal to or more than room temperature.

Abstract: Disclosed is a photosensitive resin printing plate material, which comprises at least a support, a photosensitive resin layer and a photocoloring layer, and in which the photocoloring layer is UV-transmissive before colored, and is colored through exposure to light having a wavelength of from 450 to 1500 nm to be substantially UV-non-transmissive. This is transparent and can reproduce any fine relief, not requiring an original picture film.

Abstract: A train control system includes positioning systems at the end of the train and at the front of the train, allowing the conductor or engineer to unambiguously determine that no cars of the train have become detached. The positioning system at the end of the train is also used to verify that the entire train has cleared a block. This information can be relayed to a dispatcher, thereby eliminating the need for trackside sensing equipment. A control unit prevents the train from moving without an authorization that includes the train's current position.

Abstract: A method of improving the viewing angle of a vertically-aligned liquid crystal display device is presented. The method involves designing a uniaxial compensation film to provide a retardation value of 200 nm or less for light having a wavelength of about 550 nm. Using this uniaxial compensation film, a display device can be built by obtaining a liquid crystal panel with liquid crystal molecules contained between glass substrates, coupling the uniaxial compensation film to at least one of the glass substrates, and coupling a polarization film and electrodes to the compensation film. Preferably, the uniaxial compensation film has a thickness less than or equal to 50 microns. Where there are multiple compensation films, the total thickness and the total retardation values should be considered.