Abstract: A hybrid three-axis magnetic sensor for calculating the accurate direction of the earth magnetism. The hybrid three-axis magnetic sensor includes: a flux gate type magnetic sensor which is so formed that a base serves as a main member and detects two axis components of a magnetic vector defined by a plane parallel to the base; a Hall element which detects another component of the magnetic vector orthogonal to the base; a tilt sensor which detects a tilt angle of the base; and a CPU, wherein the flux gate type magnetic sensor and the Hall element are integrally structured together as a hybrid IC. The thus detected three dimensional magnetic vector is corrected in the light of inclination of the base, so that the direction of the earth magnetism is accurately calculated.

Abstract: The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.

Abstract: Improvements to the acquisition and replay systems for direct-to-digital holography and holovision are described. A method of recording an off-axis hologram includes: splitting a laser beam into an object beam and a reference beam; reflecting the reference beam from a reference beam mirror; reflecting the object beam from an illumination beamsplitter; passing the object beam through an objective lens; reflecting the object beam from an object; focusing the reference beam and the object beam at a focal plane of a digital recorder to form an off-axis hologram; digitally recording the off-axis hologram; and transforming the off-axis hologram in accordance with a Fourier transform to obtain a set of results. A method of writing an off-axis hologram includes: passing a laser beam through a spatial light modulator; and focusing the laser beam at a focal plane of a photorefractive crystal to impose a holographic diffraction grating pattern on the photorefractive crystal.

Abstract: Growth differentiation factor-14 (GDF-14) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-14 polypeptide and polynucleotide sequences.

Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic.

Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue.

Abstract: Systems and methods are described for loss dielectrics. A loss dielectric includes at least one high dielectric loss layer and at least one high thermal conductivity-electrically insulating layer adjacent the at least one high dielectric loss layer. A method of manufacturing a loss dielectric includes providing at least one high dielectric loss layer and providing at least one high thermal conductivity-electrically insulating layer adjacent the at least one high dielectric loss layer. The systems and methods provide advantages because the loss dielectrics are less costly and more environmentally friendly than the available alternatives.

Abstract: A frequency sweep voltage controlled oscillator (VCO), with a selectable range of output frequencies is provided. The VCO includes a frequency range circuit to accept an input signal, differentially delay the signal, and selectably sum the delayed signals to provide signals in discrete frequency ranges. A frequency sweep circuit accepts the signal output from the frequency range circuit, differentially delays the signal, and sums the delayed signal in such a way as to modify the previously selected frequency range. A method for generating a signal from a frequency sweep VCO is also provided.

Abstract: The present invention provides a remote afterloader for moving a radiation source into and out of a catheter inserted in a tumor may include one or more radiation source cassettes, one or more motors, and a shielded container for storing the radiation source cassettes and the motor. Each radiation source cassette may include a radiation source wire having the radiation source connected to a treating end and a dummy source wire having a dummy source connected to a treating end. The motor advances and retracts the radiation source wire and the dummy source wire into and out of each radiation source cassette one at a time.

Abstract: Systems and methods are described for addressable field emission array (AFEA) chips. A method of operating an addressable field-emission array, includes: generating a plurality of electron beams from a pluralitly of emitters that compose the addressable field-emission array; and focusing at least one of the plurality of electron beams with an on-chip electrostatic focusing stack. The systems and methods provide advantages including the avoidance of space-charge blow-up.

Abstract: Methods, systems and devices are described relating to a chassis for front and back inserted modules. An apparatus includes a chassis including a first module bay and a second module bay, the first module bay and the second module bay together composing both a forward section and rearward section.

Abstract: The present invention includes a fluorescent compound that can detect an activity, such as an enzymatic activity, and exhibits quenching. The fluorescent compound can include a fluorescent protein, such as an Aequorea-related green fluorescent protein. The fluorescent compound can include a substrate site for an enzymatic activity such as a kinase activity, a phosphatase activity, a protease activity, and a glycosylase activity. The fluorescent compound of the present invention can be used to detect such enzymatic activities in samples, such as biological samples, including cells. The present invention also includes nucleic acids that encode the fluorescent compounds of the present inventions, and cells that include such nucleic acids or fluorescent compounds.

Abstract: Systems and methods are described for multi-link segmentation and reassembly for bonging multiple virtual circuits in an inverse multiplexing arrangement. A method includes: generating a plurality of multilink segmentation and reassembly sublayer cells at a first location; distributing the plurality of multilink segmentation and reassembly sublayer cells across a plurality of virtual circuits; transmitting the plurality of multilink segmentation and reassembly sublayer cells to a second location via the plurality of virtual circuits; and receiving the plurality of multilink segmentation and reassembly sublayer cells at the second location. An apparatus includes a multilink segmentation and reassembly sublayer transmitter, including: a source buffer; a multilink controller coupled to the source buffer; and a plurality of virtual circuits coupled to the multilink controller.

Abstract: A memory device includes a sense circuit comprising a sense amplifier, a reference sense circuit and a comparator. The sense amplifier detects a signal on a bit line associated with a column of memory cells in a memory array. The reference sense circuit detects a signal on a reference bit line associated with a column of reference cells in the memory array. The comparator compares the outputs of the sense amplifier and the reference sense circuit and provides a signal indicative of the contents of the read memory cell. In response to a transition of an address, the bit line and the reference bit line are precharged prior to reading of the memory cell. The reference sense circuit includes a selectable load that is disabled during the initial time after the address transition so that the bit line and the reference bit line rises substantially identically and then enabled to allow the reference bit line to settle to a steady state.

Abstract: Disclosed are peptides related to human TGF-&agr;, having TGF-&agr; biological activity, which are useful for many of the indications that full-length TGF-&agr; polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF-&agr; and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF-&agr; related peptides to related neurodengenerative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.

Abstract: A memory alias adapter, coupled to a processors memory bus, monitors processor memory accesses. Whenever a memory access corresponds to shared memory, rather than memory local to the processor, the adapter constructs a memory request message, and transmits the message over a network link to a shared memory unit. The shared memory unit performs the shared memory access and issues a response message over the network link. The memory alias adapter accepts the response message, and completes processor's memory access on the memory bus.

Abstract: In a computer system constituted by a portable computer and a desk station used to expand the function of the portable computer, the portable computer has a communication connector used for communication with the desk station, in addition to a connector for connecting a system bus in the portable computer to the desk station. Temperature control in the portable computer is also executed. The computer may include a one-chip controller that includes an element having a characteristic that varies with temperature and further includes a dedicated pin electrically connected to the element. The element may be mounted on a portion of an integrated circuit substrate. The dedicated pin may be provided on a portion of a connection pin arrangement.

Abstract: A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.

Abstract: A condition is detected between an inlet port of an inflatable thermal device, such as an inflatable thermal blanket, and an end of an air hose through which a flow of pressurized, thermally treated air is provided to the device by way of the inlet port. The condition may be disconnection of the end of the air hose from the inlet port or the identification of a particular style of inflatable thermal device. A response to the condition may include provision of a perceptible indication that the condition has occurred. Other responses may include cessation of the flow of air or changing an air flow characteristic.

Abstract: Growth differentiation factor-15 (GDF-15) polynucleotide sequence and amino acid sequence are provided herein. Also described are diagnostic and therapeutic methods of using GDF-15 polypeptide and polynucleotide sequences.