Abstract: This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
Abstract: The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.
Type:
Grant
Filed:
February 16, 2007
Date of Patent:
April 6, 2010
Assignee:
Pfizer Inc.
Inventors:
Peter Jones, David Pryde, Thien Duc Tran
Abstract: Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
Type:
Grant
Filed:
July 11, 2003
Date of Patent:
April 6, 2010
Assignee:
Pfizer Inc.
Inventors:
Bore G. Raju, Hardwin O'Dowd, Hongwu Gao, Dinesh V. Patel, Jaoquim Trias
Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
Type:
Grant
Filed:
April 25, 2005
Date of Patent:
April 6, 2010
Assignee:
Pfizer, Inc.
Inventors:
Klaus Ruprecht Dress, Qiyue Hu, Ted William Johnson, Michael Bruno Plewe, Steven Paul Tanis, Huichun Zhu, Junhu Zhang
Abstract: The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2, and R3 are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof in the treatment of, inter alia, conditions, diseases, and symptoms including, inter alia, Alzheimer's Disease, cancer, dementia, depression, diabetes, hair loss, schizophrenia, and stroke.
Abstract: The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
Type:
Grant
Filed:
July 5, 2005
Date of Patent:
March 2, 2010
Assignee:
Pfizer Inc.
Inventors:
Lain-Yen Hu, Bruce A. Lefker, Daniel Y. Du, Yvonne Dorothy Smith, Huangshu Lei, William Glen Harter, Victoria Leigh Downs, Mark L. Boys, Donna Michele Iula
Abstract: The compounds of formula (I) or a pharmaceutically acceptable salt, solvate or pro-drug thereof, are proline derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, fibromyalgia, arthritis, neuropathalogical disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.
Abstract: This invention relates to compounds of the formulae I wherein R1-R8, A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
Type:
Grant
Filed:
April 29, 2005
Date of Patent:
February 9, 2010
Assignee:
Pfizer Inc
Inventors:
Nancy S. Barta, Shelly Ann Glase, David L. Gray, Gregory A. Reichard, Lloyd Jerome Simons, Wenijan Xu
Abstract: The present invention is directed to crystalline forms of 6-[[(3S,4R)-3,4-dihydro-3-hydroxy-6-[(3-hydroxypheny)sulfonyl]-2,2,3-trimethyl-2H-1-benzopyran-4-yl]oxy]-2-methyl-3(2H)-pyridazinone, formulations containing at least one of these crystalline forms and their use to promote hair growth.
Type:
Grant
Filed:
July 4, 2005
Date of Patent:
February 2, 2010
Assignee:
Pfizer Inc.
Inventors:
Vladimir Genukh Beylin, Javier Magano, Julie Kwon Spence, James Anthony Wesley
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
Abstract: Forming amorphous atorvastatin comprises the steps of dissolving atorvastatin in a hydroxylic solvent, followed by rapidly evaporating the solvent. In another aspect, a composition comprises particles of amorphous atorvastatin and a core.
Type:
Grant
Filed:
April 20, 2004
Date of Patent:
February 2, 2010
Assignee:
Pfizer Inc.
Inventors:
Douglas A. Lorenz, Kenneth Craig Waterman
Abstract: The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.
Type:
Grant
Filed:
February 19, 2004
Date of Patent:
February 2, 2010
Assignee:
Pfizer Inc.
Inventors:
David L. Shelton, German J. Vergara, Carole M. Loo
Abstract: The present invention relates to a class of substituted 1,2,4-triazoles of formula (1) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).
Type:
Grant
Filed:
October 30, 2007
Date of Patent:
January 19, 2010
Assignee:
Pfizer Inc.
Inventors:
Alan Daniel Brown, David Ellis, Christopher Ronald Smith
Abstract: The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
Type:
Grant
Filed:
February 3, 2005
Date of Patent:
January 19, 2010
Assignee:
Pfizer Inc
Inventors:
Andrew Antony Calabrese, David Sebastien Fradet, David Hepworth, Mark Lansdell
Abstract: A method is disclosed for the sealing of hard shell capsules having coaxial body parts which overlap when telescopically joined. Also described is an apparatus to seal the capsules. The method comprises the steps of holding the capsule in a precise and upright position and injecting a quantity of sealing fluid in the overlap of the body parts. An apparatus for performing the method is also disclosed. The apparatus comprises a sealing clamp to hold the capsule in an upright position and means to inject the sealing fluid in the overlap of the body parts.
Type:
Grant
Filed:
March 8, 2004
Date of Patent:
January 12, 2010
Assignee:
Warner-Lambert Company LLC
Inventors:
Dominique Nicolas Cade, Frederic Hoehn, Philippe Charles Peter, Robert Anthony Scott
Abstract: The present invention provides antibacterial agents having the formulae I, II, and III described herein.
Type:
Grant
Filed:
September 21, 2006
Date of Patent:
January 12, 2010
Assignee:
Pfizer Inc
Inventors:
Richard C. Thomas, Toni-Jo Poel, Michael R. Barbachyn, Mikhail F. Gordeev, Gary W. Luehr, Adam Renslo, Upinder Singh, Vara Prasad Venkata Negandra Josyula
Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
Type:
Grant
Filed:
September 14, 2005
Date of Patent:
December 8, 2009
Assignee:
Pfizer Inc
Inventors:
Balekudru Devadas, John Walker, Shaun R. Selness, Terri L. Boehm, Richard C. Durley, Rajesh Devraj, Brian S. Hickory, Paul V. Rucker, Kevin D. Jerome, Heather M. Madsen, Edgardo Alvira, Michele A. Promo, Radhika M. Blevis-Bal, Laura D. Marruto, Jeff Hitchcock, Thomas Owen, Win Naing, Li Xing, Huey S. Shieh, Aruna Sambandam, Shuang Liu, Ian L. Scott, Kevin F. McGee
Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
Type:
Grant
Filed:
March 16, 2005
Date of Patent:
December 8, 2009
Assignee:
Pfizer Inc
Inventors:
Alan Daniel Brown, Charlotte Alice Louise Lane, Paul Alan Glossop, David Anthony Price, Russell Andrew Lewthwaite, Mark Edward Bunnage, Kim James, Graham Lunn
Abstract: The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
Type:
Grant
Filed:
September 6, 2006
Date of Patent:
November 24, 2009
Assignee:
Pfizer Inc.
Inventors:
Javier Gonzalez, Tanya Michelle Jewell, Hui Li, Angelica Linton, John Howard Tatlock