Abstract: The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).
Abstract: Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein. where R1, R2, R3, R4, R5, and R6 are described herein.
Type:
Grant
Filed:
September 10, 2007
Date of Patent:
November 17, 2009
Assignee:
Pfizer Inc.
Inventors:
Roger B. Ruggeri, George T. Magnus-Aryitey
Abstract: An injection apparatus for injecting and/or removing substances from subjects, such as avian eggs, includes an injection needle having a body portion and a tapered portion that terminates at a tip. A tube is attached to and extends around the injection needle in substantially concentric relationship therewith. The tube has an end portion positioned a predetermined distance from the needle tip. The tube end portion acts as a stop to limit the distance the needle tip can be inserted into a subject, such as an egg, through a membrane of the subject. A detector may be utilized to measure force exerted on a membrane of an egg by a stop attached to a needle. Force exerted on a membrane by a needle and/or by a needle and a stop attached to the needle may also be measured.
Type:
Grant
Filed:
October 5, 2005
Date of Patent:
November 17, 2009
Assignee:
Embrex, Inc.
Inventors:
Stephen P. Wolfe, Phillip L. Rybarczyk, Jr., Sean Bryan, Mike Schnupper, Dan Rees, Jamie Sprenkel, Edward W. Gross, Brantley Angell, John H. Hebrank
Abstract: Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein. where R, R1, R2a, R2b, R3, R4, V, R6, R7, R8, R9, W and X are described herein.
Type:
Grant
Filed:
November 13, 2007
Date of Patent:
November 10, 2009
Assignee:
Pfizer Inc.
Inventors:
Roger B. Ruggeri, George T. Magnus-Aryitey, Benjamin A. Thuma
Abstract: Egg candling methods and apparatus are provided wherein non-live eggs, inverted egg, and side air cell eggs can be quickly identified. A method of candling eggs includes exposing a plurality of incubated eggs to an environment having a temperature different from a temperature at which the eggs were incubated; obtaining a thermal image of the eggs; and analyzing the thermal image to obtain surface temperature information for each egg. The surface temperature information is utilized to designate each egg as live/non-live, inverted, or having a side air cell.
Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
Type:
Grant
Filed:
March 19, 2007
Date of Patent:
November 3, 2009
Assignee:
Pfizer Inc
Inventors:
Kim James, Lyn Howard Jones, David Anthony Price
Abstract: The present invention relates to a method of treating pain using a compound of formula wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to certain novel derivatives of formula (I).
Type:
Grant
Filed:
April 28, 2006
Date of Patent:
November 3, 2009
Assignee:
Pfizer Inc.
Inventors:
Shelley Rene Graham, Simon John Mantell, David James Rawson, Jacob Bradely Schwarz
Abstract: The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogens
Type:
Grant
Filed:
March 7, 2007
Date of Patent:
October 20, 2009
Assignee:
Pharmacia & Upjohn Company LLC
Inventors:
Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
Abstract: This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity.
Type:
Grant
Filed:
November 2, 2005
Date of Patent:
October 6, 2009
Assignee:
Pfizer Inc.
Inventors:
Kana Kon-I, Miyako Matsumizu, Akiko Shima
Abstract: This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1, R2, R3, R4 and R5 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, as gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes or apnea syndrome.
Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
Type:
Grant
Filed:
February 18, 2008
Date of Patent:
September 1, 2009
Assignee:
Pfizer Inc
Inventors:
Tanisha D. Blake, Bruce C. Hamper, Wei Huang, James R. Kiefer, Jr., Joseph B. Moon, Bradley E. Neal, Kirk L. Olson, Matthew J. Pelc, Barbara A. Schweitzer, Atli Thorarensen, John I. Trujillo, Steven R. Turner
Abstract: The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
Type:
Grant
Filed:
August 22, 2007
Date of Patent:
August 25, 2009
Assignee:
Pfizer Inc
Inventors:
Ronald Biediger, Jie Chen, Daxin Gao, Robert Market, Chengde Wu
Abstract: The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia.
Type:
Grant
Filed:
February 8, 2005
Date of Patent:
August 18, 2009
Assignee:
Pfizer Inc.
Inventors:
Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
Abstract: The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein: A is selected from C—X and N, B is selected from C—Y and N, R1 is selected from H and (C1-C6)alkyl, R2 is selected from H and (C1-C6)alkyl, X is selected from H, HO, C(O)NH2, NH2 Y is selected from H, HO, NH2, Br, Cl and F Z is selected from H, HO F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (Ia) or (Ib), when A is C—X, B is C—Y, R1 is H or (C1-C6)alkyl and R2 is H or (C1-C6)alkyl at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C—X and B is C—Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as a medicament.
Type:
Grant
Filed:
June 19, 2006
Date of Patent:
August 18, 2009
Assignee:
Pfizer Inc.
Inventors:
Charlotte Moira Norfor Allerton, Andrew Douglas Baxter, Andrew Simon Cook, David Hepworth, Stephen Kwok-Fung Wong
Abstract: The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
Type:
Grant
Filed:
November 3, 2006
Date of Patent:
August 11, 2009
Assignee:
Pfizer Inc.
Inventors:
Stephen Mark Denton, Karl Richard Gibson, Melanie Susanne Glossop, Mark Ian Kemp, Cedric Poinsard
Abstract: This invention relates to compounds of formula (I)
Type:
Grant
Filed:
November 24, 2004
Date of Patent:
August 11, 2009
Assignee:
Pfizer Inc
Inventors:
Andrew Simon Bell, David Graham Brown, Kevin Dack, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Michael John Palmer, Carol Ann Winslow
Abstract: This invention relates to compounds of formula (I).
Type:
Grant
Filed:
March 30, 2005
Date of Patent:
August 4, 2009
Assignee:
Pfizer Inc
Inventors:
Andrew Simon Bell, David Graham Brown, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Dafydd Rhys Owen, Michael John Palmer, Carol Ann Winslow, Hwang Fun Lu, Thomas Edward Rogers
Abstract: This invention provides compounds of the formula (I) useful for the treatment of disease conditions caused by over activation of Vr1 receptors such as pain or the like in mammals as well as compositions comprising them.
Abstract: The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or diluent are also provided. These pharmaceutical are useful to treat a variety of disorders associated with dyslipidemia.
Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
Type:
Grant
Filed:
March 7, 2005
Date of Patent:
July 21, 2009
Assignee:
Pfizer Inc.
Inventors:
Richard John Sciotti, Jeremy Tyson Starr, Christopher Richardson, Gordon William Rewcastle, Huifen Chen, Brian Desmond Palmer, Hamish Scott Sutherland, Julie Ann Spicer