Patents Represented by Attorney Gregg C. Brown
  • Patent number: 5939369
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: August 17, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Patent number: 5900213
    Abstract: N,N-dialkyl and N'-alkylethylene diamines of the formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are as described in the specification. The compounds are useful in disinfecting and cleaning contact lenses and preserving ophthalmic products.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: May 4, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park, Bahram Asgharian
  • Patent number: 5811466
    Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood Chowhan, Nissanke L. Dassanayake
  • Patent number: 5811438
    Abstract: The compounds of the present invention are of the formula (I): A--X--(CH.sub.2).sub.n --Y--(CH.sub.3).sub.m --Z wherein: A is an non-steroidal anti-inflammatory agent (NSAIA); A--X is an ester or amide linkage derived from the carboxylic acid moiety of the NSAIA, wherein X is O or NR; R is H, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl; Y, if present, is O, NR, C(R).sub.2, CH(OH) or S(O).sub.n' ; n is 2 to 4 and m is 1 to 4 when Y is O, NR, or S(O).sub.n' ; n is 0 to 4 and m is 0 to 4 when Y is C(R).sub.2 or is not present; n is 1 to 4 and m is 0 to 4 when Y is CH(OH); n' is 0 to 2; and Z is (a), (b), (c), (d) or (e) wherein: R' and R.sup.3 are H, C(O)R, C(O)N(R).sub.2, PO.sub.3.sup.-, or SO.sub.3.sup.- ; R" is H or C.sub.1 -C.sub.6 alkyl; and R' and R.sup.3 together may form a ring having structure: (1) or (2); and provided that when Z is (e), X is not O. The compounds of the present invention also include pharmaceutically acceptable salts of the compounds of formula (I).
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: September 22, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, Gustav Graff, Daniel A. Gamache, Jon C. Nixon, William H. Garner
  • Patent number: 5741817
    Abstract: The use of glycine and other low molecular weight amino acids in ophthalmic compositions (e.g., preserved saline solutions) is described. These compounds have been found to enhance the efficacy of antimicrobial preservatives. The compounds also act as chelating agents, buffers and tonicity agents.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: April 21, 1998
    Inventors: Masood Chowhan, Bahram Asgharian, Paul Stach
  • Patent number: 5723421
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: March 3, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth Ann Rosenthal
  • Patent number: 5714463
    Abstract: The intraocular use of combinations of stromal cell growth stimulators (e.g., TGF-.beta.) and antimetabolites (e.g., mitomycin C) in connection with glaucoma filtration surgery is described. The combination is applied to the surgical site to attract, mitogenically activate, and neutralize the potential for extracellular matrix synthesis leading to scar formation by stromal cells. Without such treatment, the formation of scar tissue may lead to impairment of the outflow of aqueous humor at the surgical site, particularly the fistula. The mitogenic activation of the stromal cells makes these cells susceptible to the anti-metabolites. This enables the antimetabolites to suppress the proliferation of the fibroblasts and other associated stromal cells to a much greater extent, relative to the proliferation seen when the metabolites alone are utilized.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: February 3, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Billie M. York, Jon C. Nixon
  • Patent number: 5705510
    Abstract: The use of certain dopaminergic compounds for controlling elevations of intraocular pressure is disclosed. The compounds are ergoline derivatives. The most preferred compound is cabergoline. The compounds have been found to produce a significant reduction of intraocular pressure.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: January 6, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis DeSantis, Jr., Verney L. Sallee, Marsha A. McLaughlin, Manoj L. Maniar
  • Patent number: 5696091
    Abstract: The intraocular use of combinations of lens epithelial cell growth stimulators (e.g., TGF-.beta.) and antimetabolites (e.g., mitomycin C) is described. The combination is applied to the capsular bag to prevent or retard the formation of secondary cataracts following cataract surgery. The lens epithelial cell stimulators activate DNA synthesis in dormant lens epithelial cells, and thereby make those cells susceptible to the anti-metabolites. This enables the antimetabolites to suppress the proliferation of lens epithelial cells to a much greater extent, relative to the proliferation observed when the metabolites alone are utilized. The increased suppression of the growth of lens epithelial cells results in a significant improvement in the ability to prevent or retard the formation of opacities on the lens capsule (i.e., secondary cataracts).
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: December 9, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Billie M. York, Jon C. Nixon, Karen C. Sams
  • Patent number: 5691360
    Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 25, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, George Barnes, Robert J. Collier, Jr.
  • Patent number: 5672575
    Abstract: A contact lens cleaning solution containing an enzyme having proteolytic activity and a surfactant, and optionally also a chelating agent and urea, and a method of cleaning contact lenses utilizing this solution are described. The solution and method effectively remove deposits of proteinaceous material, mucins, lipids and calcium located either on or beneath the surface of the lens.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: September 30, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventor: Rolf Schafer
  • Patent number: 5654262
    Abstract: Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: August 5, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nayan N. Desai, Ronald P. Quintana, Masood A. Chowhan
  • Patent number: 5650541
    Abstract: Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: July 22, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventor: Jesse A. May
  • Patent number: 5646149
    Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, George Barnes, Robert J. Collier, Jr.
  • Patent number: 5631004
    Abstract: An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: May 20, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald D. Cagle, Tai-Lee Ke, Barry A. Schlech, Ole J. Lorenzetti
  • Patent number: 5631005
    Abstract: The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described. The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: May 20, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park
  • Patent number: 5627214
    Abstract: Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: May 6, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rolf Schafer, Ronald L. Schlitzer, Nissanke L. Dassanayake
  • Patent number: 5607966
    Abstract: Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: March 4, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, Gustav Graff
  • Patent number: 5604190
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent, and complexing agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 18, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Patent number: 5591397
    Abstract: An improved method for rapid disinfection of contact lenses in a convenient and reliable manner is disclosed in which a series of oxidation-reduction reactions are employed. Specifically, dichloroisocyanurate and potassium iodide react to form iodine species for disinfecting the contact lens. An amount of ascorbate is then added to neutralize the iodine species.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 7, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Ronald L. Schlitzer, N. L. Dassanayake, Rajkumar P. Bhatia