Abstract: Disclosed are nonstinging, sustained release ophthalmic formulations to control intraocular pressure in antiglaucoma therapy comprising a basic active, a cation exchange resin, and, inter alia, an acidic, mucomimetic polymer. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when indicated for control and lowering of intraocular pressure.

Abstract: A means, method, and system for storing and caring for contact lenses, including cleaning, rinsing, storing, disinfecting, lubricating, etc., including a self-contained contact lens holder to support and contain one or more contact lenses. A fluid conduit is associated with the contact lens holder to provide a pathway for fluid to the chamber or chambers holding each contact lens. A fluid container holding a fluid used in contact lens care can be put in fluid communication with the fluid conduit and is operable to selectively introduce fluid into the fluid conduit and fill the contact lens holder with the fluid. The contact lens holder, fluid contact, and fluid container may all be incorporated in a unitary body, or fluid container and/or the fluid conduit can be selectively attachable to the contact lens holder so that different fluid containers can be interchangeable to the contact lens holder.

Abstract: A method for packaging intraocular lenses, contact lenses and other small, delicate devices which must be stored in a liquid is described. The method utilizes a container having a conically-shaped compartment to package small, delicate devices (e.G., intraocular lenses) in a manner such that the devices may be easily located in the compartment and removed from the container.

Abstract: Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.

Abstract: Disclosed are antibiotic compositions for topical administration comprising an aminoglycoside, a benzylpyrimidine and a sulfonamide.

Abstract: A system and method for disinfecting contact lenses with a stabilized hydrogen peroxide solution and a separate neutralizing solution are described. Sodium stannate (a.k.a. sodium tin oxide) is utilized to stabilize the hydrogen peroxide, and sodium thiosulfate is utilized to neutralize the hydrogen peroxide. In addition to sodium thiosulfate, the neutralizing solution also contains a complexing agent capable of sequestering tin, such as EDTA or EGTA. The system and method provide improvements over prior hydrogen peroxide disinfection systems with respect to stability, predictability and rate of reaction.

Abstract: An apparatus and method for aseptic, particle-free production of articles. A shroud is placed around at least a portion of the device which produces the articles to substantially isolate that portion from the external environment. The device for producing the articles and the shroud are sterilized and the air inside the shroud is filtered and sterilized. A laminar or other type of flow of filtered, sterilized air is imparted through the shroud over the articles being produced. A secondary shroud encloses the corridor or work area adjacent the shroud and device which produces the articles. The corridor and secondary shroud are sterilized, and sterilized and filtered air is continually introduced therein. The articles therefore are particle-free and sterilized for further use. The apparatus and method can be used for any component production process employing high temperatures and/or pressures, including, but not limited to, blow molding, injection molding, and production of semiconductor electronic components.

Abstract: A device for storage, mixing, and dispensing of two separate materials, including but not limited to liquids, semi-liquids, powders, and granulated materials. The first and second containers include neck portions which are matably slidable within one another, the necks defining openings into each container. A plug member is retentively held in the neck of either container, and extends to a stopper portion which blocks fluid flow through the neck of the one container when it is positioned in the neck of the other container, thus separating the two independent materials during storage. A sleeve extends over the second container and at least a portion of the first container. A removable collar can be positioned between the second container and the first container to hold them in a position where the materials are separated for storage.

Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.

Abstract: A device for controlling the release of retracted haptics on an intraocular lens is described. By controlling the retraction of the haptics, it is possible to obtain a more precise placement of the lens in the eye. The lens is attached to the device by means of sutures, which allows the lens to be safely and conveniently positioned in the eye.

Abstract: Contact lens cleaning compositions containing a carboxy vinyl polymer, and a method of cleaning contact lenses with such compositions are descrived. The compositions are capable of cleaning soiled contact lenses very rapidly and completely due to the cleaning action of an abrasive precipitate formed by the carboxy vinyl polymer component when a small amount of compositions is rubbed on the lenses.

Abstract: A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium calcium chloride, and bicarbonate ions as well as dextrose, glutathione, and gamma-amino butyric acid (GABA) or functional analogue(s) of GABA, or a mixture of GABA and such analogue(s) in proportions consistent with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.

Abstract: Topical ophthalmic compositions containing one or more retinoids selected from the group consisting of near and remote analogues and derivatives of retinoic acid are described. Six classes of ophthalmic vehicles suitable as carriers for the retinoids are also described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.

Abstract: Disclosed is the use of Tri-methyl PG-F.sub.2 a, and its derivatives, such as, 15-acetyl Tri-methyl PG-F.sub.2 a and pharmaceutically acceptable esters thereof in the treatment of glaucoma and intraocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising Tri-methyl PG-F.sub.2 a and its derivatives.

Abstract: Disclosed is the use of trimoprostil, and its derivatives, such as, 15-acetyl trimoprostil and pharmaceutically acceptable salts and esters thereof in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising trimoprostil and its derivatives.

Abstract: A method for reducing the size of hydrogel intraocular lenses by means of deswelling in hyperosmotic solutions (e.g., saturated sodium chloride solution) and a corresponding packaging arrangement are described. The deswelled, hydrogel lenses can be inserted through a much smaller surgical incision than fully hydrated lenses, yet retain all of the inherent advantages of hydrogel intraocular lenses (e.g., autoclavability). The lenses are rehydrated by the aqueous humor following implantation.

Abstract: A hypotraumatic injection needle having substantially no cutting edges is described. The injection needle has a beveled surface with the furthermost end of the beveled surface removed and rounded to form the needle tip. All edges on the tip and beveled portion of the needle are rounded and smoothly polished. The needle tip has a low profile, with the slope of the beveled portion being less than twenty degrees. These features allow the needle to penetrate easily by means of blunt dissection of tissue, rather than cutting tissue. The injection needle is particularly useful for posterior peribulbar or retrobulbar anesthesia in connection with ophthalmic surgery. The injection needle has a "ski-tip" effect, guiding the tip of the needle away from the beveled side. This effect, along with the absence of cutting edges, significantly reduces the hazards associated with ophthalmic surgical injections, such as inadvertent cutting of the eyeball or optic nerve.

Abstract: Nontoxic, aqueous, contact lens cleaning compositions containing a weakly anionic surfactant, and optionally also a chelating agent, urea and/or a source of hydrated protons, and methods of chemically removing protein, lipid and calcium deposits from contact lens utilizing these compositions are described.

Abstract: Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.

Abstract: A two compartment container adapted for the packaging of intraocular lenses, contact lenses and other small, delicate devices requiring hydrated storage is described. The devices are contained in a first, upper compartment, while a second, lower compartment contains a fluid. The two compartments are placed in fluid communication with each other by means of a narrow passage which prevents the devices in the first compartment from entering the second compartment.