Patents Represented by Attorney Gregory R. Bellomy

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  • Engineered anti-IL-23R antibodies
    Patent number: 8309085
    Abstract: Antibodies to human IL-23R are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: November 13, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Leonard G. Presta
  • Engineered anti-IL-23P19 antibodies
    Patent number: 8293883
    Abstract: Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g., in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: October 23, 2012
    Assignee: Schering Corporation
    Inventor: Leonard G. Presta
  • Lyophilized formulations of engineered anti-IL-23p19 antibodies
    Patent number: 8263748
    Abstract: The present invention provides lyophilized formulations of antibodies, such as antibodies that specifically bind to human interleukin-23 p19 (IL-23p19), or antigen binding fragments thereof.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: September 11, 2012
    Assignee: Schering Corporation
    Inventors: Xuhong Li, Ramesh S. Kashi, Aniket Badkar
  • Use of agonists and antagonists of IL-23 in the treatment of viral infection
    Patent number: 8263080
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating viral infections. Also provided are reagents for use in screening for agonists or antagonists of IL-23.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: September 11, 2012
    Assignee: Schering Corporation
    Inventors: Peter D. Katsikis, Ioannis Dimitriou, Daniel J. Cua
  • IL-1-like cytokine antibodies
    Patent number: 8197812
    Abstract: Nucleic acids encoding mammalian, e.g., primate, IL-1?, purified IL-1? polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: June 12, 2012
    Assignee: Schering Corporation
    Inventor: Jacqueline C. Timans
  • Method of treating asthma or allergy by administering an IL-33 receptor antibody
    Patent number: 8187596
    Abstract: Provided herein are methods of modulating IL-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing IL-33 signaling.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: May 29, 2012
    Assignee: Schering Corporation
    Inventors: Alissa A. Chackerian, Robert A. Kastelein
  • IL-B30 antibodies
    Patent number: 8182810
    Abstract: Purified genes encoding cytokine referred to as interleukin-B30 (IL-B30) from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: May 22, 2012
    Assignee: Schering Corporation
    Inventor: J. Fernando Bazan
  • Method of treating skin inflammation
    Patent number: 8178095
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 15, 2012
    Assignee: Schering Corporation
    Inventors: Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy, Jason R. Chan
  • Methods for inhibiting tumor growth or reducing metastatic burden in a subject by administering FDF03 antibodies
    Patent number: 8178094
    Abstract: The present invention relates to methods for identifying and using modulators of FDF03 biological activity in vitro and in vivo that are useful in the treatment of cancer.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: May 15, 2012
    Assignee: Schering Corporation
    Inventors: Michael E. Bigler, Drake M. LaFace, Kalyan Pande, Joseph H. Phillips
  • Use of IL-27 agonists to increase interferon-gamma production
    Patent number: 8178308
    Abstract: Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: May 15, 2012
    Assignee: Schering Corporation
    Inventors: Rene de Waal Malefyt, Marilyn Travis, Elena Vaisberg
  • Engineered anti-IL-23R antibodies
    Patent number: 8119133
    Abstract: Antibodies to human IL-23R are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: February 21, 2012
    Assignee: Schering Corporation
    Inventor: Leonard G. Presta
  • Nucleic acids encoding DCRS5
    Patent number: 8110378
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: February 7, 2012
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Mammalian receptor protein DCRS5; methods of treatment
    Patent number: 8097255
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: January 17, 2012
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin Moore, Christi L. Parham
  • IL-D80 polynucleotides
    Patent number: 8080392
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: December 20, 2011
    Assignee: Schering Corporation
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Methods of treating cutaneous ulcers and grafts using agonist antibodies to IL-23 receptor
    Patent number: 8062634
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: November 22, 2011
    Assignee: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • Methods of inhibiting tumor growth using blocking antibodies to IL-23R
    Patent number: 8034341
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for modulating activity of a cytokine molecule and its receptor.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: October 11, 2011
    Assignee: Schering Corporation
    Inventors: Martin Oft, Terrill K. McClanahan
  • Monocyte-derived nucleic acids and related compositions and methods
    Patent number: 8026351
    Abstract: Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: September 27, 2011
    Assignee: Schering Corporation
    Inventors: Elizabeth Bates, Nathalie Fournier, Lionel Chalus, Pierre Garrone
  • Antibodies that bind DNAX leukocyte associated immunoglobulin-like receptor
    Patent number: 7999078
    Abstract: Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: August 16, 2011
    Assignee: Schering Corporation
    Inventors: Gosse Jan Adema, Linde Meyaard, Daniel M. Gorman, Terrill K. McClanahan, Sandra Zurawski, Gerard Zurawski, Lewis L. Lanier, Joseph H. Phillips, Jr.
  • DCRS5 polypeptides
    Patent number: 7964703
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: June 21, 2011
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Mammalian cytokines; related reagents and methods
    Patent number: 7939297
    Abstract: Nucleic acids encoding mammalian, e.g., primate, IL-1?, purified IL-1? polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: May 10, 2011
    Assignee: Schering Corporation
    Inventor: Jacqueline C. Timans