Abstract: Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided.
Type:
Grant
Filed:
February 17, 2004
Date of Patent:
April 26, 2011
Assignee:
Schering Corporation
Inventors:
Elizabeth Bates, Nathalie Fournier, Lionel Chalus, Pierre Garrone
Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
Type:
Grant
Filed:
March 30, 2009
Date of Patent:
March 15, 2011
Assignee:
Schering Corporation
Inventors:
Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
Type:
Grant
Filed:
July 22, 2009
Date of Patent:
February 22, 2011
Assignee:
Schering Corporation
Inventors:
Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
Type:
Grant
Filed:
July 12, 2010
Date of Patent:
February 15, 2011
Assignee:
Schering Corporation
Inventors:
Madaline Chirica, Robert A. Kastelein, Kevin Moore, Christi L. Parham
Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
Type:
Grant
Filed:
August 10, 2006
Date of Patent:
February 8, 2011
Assignee:
Schering Corporation
Inventors:
Birgit Oppmann, Rene de Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula
Abstract: The instant specification provides methods of treatment for inflammatory and autoimmune disorders of the metabolic system. The instant specification also provides methods of diagnosis.
Abstract: Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
Type:
Grant
Filed:
August 29, 2006
Date of Patent:
October 5, 2010
Assignee:
Schering Corporation
Inventors:
Leonard G. Presta, Brian M. Beyer, Richard N. Ingram, Peter Orth, Yan-Hui Liu
Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
Type:
Grant
Filed:
September 2, 2008
Date of Patent:
August 17, 2010
Assignee:
Schering Corporation
Inventors:
Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy
Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
Type:
Grant
Filed:
July 28, 2008
Date of Patent:
July 13, 2010
Assignee:
Schering Corporation
Inventors:
Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
Type:
Grant
Filed:
September 2, 2008
Date of Patent:
June 22, 2010
Assignee:
Schering Corporation
Inventors:
Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy, Jason R. Chan