Abstract: The present invention is directed to novel process for the preparation of sulfonylimine and sulfamide derivatives.

Abstract: The present invention is directed to novel 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of ?-secretase, also known as ?-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.

Abstract: The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.

Abstract: The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

Abstract: An areal implant, in particular for abdominal wall closure, has a flexible basic structure made from a knitted fabric comprising non-resorbable or slowly resorbable material or a combination of such materials. The knitted fabric of the basic structure is designed to stretch more than the tissue region destined to receive the implant below a critical force and stretch less than this tissue region above the critical force. The critical force lies below the highest load which is allowable for this tissue region. The basic structure is provided with a stiffening, synthetic resorbable material whose resorption time is less than that of the basic structure.

Abstract: The present invention describes a polyoxaester copolymers containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The polyoxaesters copolymer of the present invention is formed from a first divalent repeating unit of formula IA:[--C(O)--R.sub.30 --C(O)--] IAa second divalent repeating unit of the formula IB:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]Iand a third repeating unit of the formula:[--O--R.sub.12 --].sub.U, XVIand optionally a fourth repeating unit with a formula selected from the group consisting of:[--O--R.sub.4 --].sub.A, II[--O--R.sub.5 --C(O)--].sub.B, III([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XIand combinations thereof wherein R.sub.12 contains an internal amine or internal amide group.

Abstract: An apparatus for ultrasonically forming a surgical suture tip from a length of unfinished surgical suture material. The apparatus includes a first tipping die having a first face for contacting a portion of the length of unfinished surgical suture material. A second tipping die having a second face is also provided. At least one mechanical actuator is provided for moving the first face of the first tipping die toward the second face of the second tipping die. A second actuator vibrates at least one of the first and second tipping dies at an ultrasonic frequency of about 15 KHz to 70 KHz.

Abstract: An apparatus and method for cutting a surgical suture at a first and second different location along its length. The apparatus having a first and a second cutting die with channels for receiving at least a portion of the cross-section of the surgical suture at each location. Each of the first and second cutting dies respectively is provided with an opposing cutting die to further restraint the suture. A blade is also provided at each cutting location for cutting the suture at a point adjacent to the respective cutting dies when the suture is restrained between the sets of dies.

Abstract: The present claims are directed to a tipped surgical suture and a solventless method for making a tipped suture comprising a suture coated with 6-30 weight percent, based on the total weight of the tipped region of the suture, of a bioresorbable aliphatic polyester copolymer which itself comprises from 70-100 mole % of e-caprolactone repeating units or from 80-100 mole % of trimethylene carbonate repeating units, the remainder of repeating units in the copolymer comprising a plurality of lactide, 1,4-dioxan-2-one, 1,4-dioxepan-2-one units.

Abstract: An apparatus and method for forming a cut end of a surgical suture tip. The apparatus including a first and second cutting dies with a channel for receiving a suture. Mechanical actuators are provided to moving the cutting dies from an open to a closed position. The cutting dies are adapted to trap and compressing the suture. A cutting blade is provided for cutting the surgical suture tip adjacent to the first and second cutting dies when the cutting dies are closed.A second cutting die having a notch which is aligned to insert in said channel and secure a suture there between. A mechanical activator is provided to move said dies. A cutting blade is provided to cut the suture secured between said dies. A method for forming cut ends of a suture tip is also described.

Abstract: An apparatus and method for thermally forming a surgical suture tip from a length of unfinished surgical suture material having a varying cross-section. The thermally formed surgical suture tip has a generally uniform cross-section along its length, and the varying cross-section corresponds to a distribution of different cross-sectional sizes along the length of the unfinished surgical suture material. A first heating die has a first face with a first groove therein for receiving a portion of the length of the unfinished surgical suture material, and a second heating die has a second face with a second groove therein. The first and second grooves extend along a common axis. At least one mechanical actuator is provided for moving the first face of the first heating die against the second face of the second heating die and for contacting the first and second grooves against an outer surface of the unfinished surgical suture material.

Abstract: A combined apparatus for heating and cutting a suture tip formed from a length of unfinished surgical suture material. First and second heating dies are provided for heating the length of unfinished surgical suture material to form the suture tip, and first and second cutting dies are provided for cutting the suture tip. At least one heating die mechanical actuator is provided for moving the first heating die between a retracted and an extended position and for moving the second heating die between a retracted and an extended position, the first and second heating dies occupying a combined heating and cutting space adjacent to the unfinished surgical suture material only when the first and second cutting dies are in their retracted positions.

Abstract: A retaining apparatus for a surgical mesh includes a top surface and a bottom surface. The top surface has a central elongated recess for receiving a portion of the surgical mesh. Retaining straps are provided for securing the surgical mesh portion to the recess. Centrally located within the recess is an inverted dimple for fitting into a cylindrical opening of the surgical mesh. The inverted dimple restricts lateral movement of the surgical mesh.

Abstract: A biocompatible fastener that may be used for attachment of a fixation plate to bone is described herein, where the fastener has features that facilitate its deployment in a surgical environment. The fastener is composed of a screw, having a threaded shaft and slotted head, and a detachable body that is used for deploying the screw and is then broken away and discarded. The slot in the head of the screw has stress concentrating notch features that direct the fracture lines into the screw head upon detachment of the secondary body, thus ensuring that the screw head surface remains smooth after deployment. A suitable driver for applying the fastener is also described.

Abstract: The present invention describes a crosslinked aliphatic polyoxaamide polymer and blends thereof that may be used to produce hydrogels, surgical devices such as catheters, molded devices, and the like. The crosslinked aliphatic polyoxaamide of the present invention are formed by crosslinking an aliphatic polyoxaamide having a first divalent repeating unit of formula I:?X--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! Iand a second repeating unit selected from the group of formulas consisting of:?--Y--R.sub.17 --!.sub.T, II?--O--R.sub.5 --C(O)--!.sub.B, and III(?--O--R.sub.9 --C(O)!.sub.P --O--).sub.L G XIand combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided both X and Y are not both --0-- and may be blended with a second polymer that is preferably biocompatable.

Abstract: Absorbable, segmented polymers of aliphatic polyesters based on lactone monomers glycolide, p-dioxanone and .epsilon.-caprolactone are described. The segmented polymers exhibit a broad range of properties, especially high strength, low modulus and fast in vivo absorption, useful in a variety of medical devices. The polymers of the present invention have such properties, making them useful in medical devices for plastic surgery indications.

Abstract: A synthesis method is set forth for forming a physiologically acceptable composition comprising a plurality of physiologically acceptable hydrogel particles which have been swollen in a water solution containing a low molecular weight water soluble organic compound, the solution having the ability to swell the particles. The concentration of the organic compound is such that the resulting particles can be inserted, without use of a carrier liquid utilizing a hand driven hypodermic syringe. The swollen hydrogel particles are substantially insoluble in body fluids. The method comprises contacting not fully swollen hydrogel particles with the organic compound and with water.

Abstract: A pin for attaching a surgical membrane barrier to tissue structure of a patient comprises a pin body 1 formed from a sequence of four truncated cones which define a serrated profile which enables the pin to engage the membrane barrier and to be pushed-fitted into the tissue structure. The head portion 2 of the pin serves to engage the membrane barrier and retain it in position on the underlying tissue structure.The pin is made from a resorbable polymer, such as PDS Polydioxanone and is of substantially solid construction throughout.In an alternative embodiment, a circularly cylindrical extension is provided between the largest truncated cone and the pin head. The arrangement serves to maintain a spacing between the membrane barrier and the underlying tissue.

Abstract: An apparatus and method for ultrasonically forming a surgical suture tip from a length of unfinished surgical suture material. The apparatus includes a first tipping die having a first face for contacting a portion of the length of unfinished surgical suture material. A second tipping die having a second face is also provided. At least one mechanical actuator is provided for moving the first face of the first tipping die toward the second face of the second tipping die. A second actuator vibrates at least one of the first and second tipping dies at an ultrasonic frequency of about 15 KHz to 70 KHz. The method of ultrasonically forming a suture tip comprises the positioning a surgical suture between the first face of the tipping die and the second face of the tipping die then vibrating the dies at an appropriate frequency.

Abstract: The furring tape is a nominal 1" to 2" wide by 0.005" to 0.100" thick strip of plastic tape with a peel and stick adhesive on one face of the strip. The strip is adhered to drywall to grip staples used to secure ceiling tiles to the drywall.