Abstract: An object of the present invention is to provide a filter device of the type that the filter element is exchangeable, said device can be easily and accurately connected and disconnected to the fixed head which leads to a plumbing system, by simple operations.
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Type:
Grant
Filed:
December 8, 2005
Date of Patent:
November 21, 2006
Assignees:
Centocor, Inc., New York University
Inventors:
Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
Abstract: The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
Type:
Grant
Filed:
January 18, 2002
Date of Patent:
November 21, 2006
Assignee:
Millennium Pharmaceuticals, Inc.
Inventors:
Lijun Wu, Nancy Ruffing-Graham, David P. Andrew
Abstract: Described herein is a system for creating and maintaining materialized views. The maintenance of the materialized views is performed in a distributed manner that improves efficiency and performance in response to the queries for materialized views or views on top of the materialized views.
Abstract: An AC-coupled display driver circuit includes one or more DC-restore switches that are integrated within a liquid crystal display. A liquid crystal display system includes a coupling capacitor coupled at one end to a system input video signal, the coupling capacitor providing a display input video signal having a DC level offset. A liquid crystal display device coupled to another end of the coupling capacitor receives the first display input video signal at a video input for driving the display device. A switch integrated within the display device provides DC restore to the coupling capacitor.
Abstract: A method and system are provided for transmitting information in a Mobile Internet Protocol (IP) environment, which includes a home agent (HA) provided at a home network, a base station (BS) broadcasting a pilot signal, a foreign agent (FA) provided at or associated with the BS, a mobile node (MN) providing the ability to detect and identify itself to a BS, and a proxy mobile node (PMN) identifying the MN wherein the PMN is provided at the BS. If the PMN identifies the MN, the PMN retrieves an IP address for each of the MN, FA and HA and sends a registration request to the FA. The FA relays the registration request to the HA, and the proxy MN is registered with the HA. Thus, the MN functionality is provided transparently to the MN by the PMN. This significantly simplifies the configuration of the MN and the Mobile IP network.
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful for therapy of TNF?-mediated pathologies and conditions, including vascular inflammatory pathologies.
Type:
Grant
Filed:
June 20, 2002
Date of Patent:
November 14, 2006
Assignees:
Centocor, Inc., New York University
Inventors:
Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
Abstract: A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.
Type:
Grant
Filed:
November 29, 2004
Date of Patent:
November 14, 2006
Assignee:
Biopure Corporation
Inventors:
Thomas C. Page, Jose O. Torres, William R. Light
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Type:
Grant
Filed:
July 13, 2005
Date of Patent:
November 14, 2006
Assignees:
Centocor, Inc., New York University
Inventors:
Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Type:
Grant
Filed:
December 30, 2004
Date of Patent:
November 14, 2006
Assignee:
sanofi pasteur limited
Inventors:
Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
Abstract: A system determines three-dimensional attitude of a moving platform using signals from two closely spaced Global Positioning System (GPS) antennas. The system includes three rate gyroscopes and three accelerometers rigidly mounted in a fixed relationship to the platform to aid in determining the attitude. The system applies signals from one of the two GPS antennas to sufficient channels of a GPS receiver to support navigation. The system applies signals from a second of the two GPS antennas to the additional receive channels to support interferometry. The system resolves the ambiguity normally associated with the interferometric heading solution by having closely spaced GPS antennas, and uses interferometry to refine a coarse heading estimate from a GPS plus Inertial Measurement Unit (IMU) transfer alignment solution. The system achieves sub-meter spacing of the two GPS antennas by merging many temporal interferometric measurements and the attitude memory provided by the IMU time-history solution.
Abstract: The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays.
Type:
Grant
Filed:
September 10, 2001
Date of Patent:
November 14, 2006
Assignees:
Boston Probes, Inc., Dako A/S
Inventors:
Kyriaki Stefano, James M. Coull, Henrik Stender, Jens J. Hyldig-Nielsen, Kenneth H. Peterson
Abstract: A system apparatus for wireless communication that includes receiving, receiving data for a subscriber, determining the subscriber to whom the data is addressed, determining which cell the subscriber currently resides, and transmitting the data accordingly.
Abstract: An X-ray irradiation apparatus includes an enclosure and an X-ray beam system positioned within the enclosure for directing X-ray beams into an irradiation region. The X-ray beam system has more than one X-ray beam emitter for directing the X-ray beams into the irradiation region from different directions. Each X-ray beam emitter includes a vacuum chamber having a target window and an electron generator positioned within the vacuum chamber for generating electrons that are directed at the target window for forming X-rays which pass through the target window as an X-ray beam. The target window is supported by a support plate having a series of holes therethrough which allow passage of the electrons therethrough to reach the target window.
Abstract: A helium management control system for controlling the helium refrigerant supply from a common manifold supplies a plurality of cryogenic refrigerators with an appropriate helium supply. The system employs a plurality of sensors to monitor and regulate the overall refrigerant supply to deliver an appropriate refrigerant supply to each of the cryogenic refrigerators depending on the computed aggregate cooling demand of all of the cryogenic refrigerators. An appropriate supply of helium is distributed to each cryopump by sensing excess and sparse helium refrigerant and redistributing refrigerant accordingly. If the total refrigeration supply exceeds the total refrigerant demand, or consumption, excess refrigerant is directed to cryogenic refrigerators which can utilize the excess helium to complete a current cooling function more quickly.
Type:
Grant
Filed:
July 20, 2001
Date of Patent:
October 31, 2006
Assignee:
Brooks Automation, Inc.
Inventors:
Paul E. Dresens, Gary S. Ash, Allen J. Bartlett, Bruce R. Andeen, Y. Roberto Than, Joseph Chopy, Jr.
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Type:
Grant
Filed:
March 4, 2003
Date of Patent:
October 31, 2006
Assignees:
Centocor, Inc., New York University
Inventors:
Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
Abstract: Mapping business and engineering processes is accomplished by giving users access to a system for generating an emergent model and publishing inputs and/or outputs of models generated by the users. Published inputs and/or outputs of models generated are subscribed to by the users, thereby creating a network of linked inputs and/or outputs. The network of linked inputs and/or outputs are analyzed and displayed, resulting in a map of the business and engineering processes. The models generated are used in business and engineering processes.
Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Abstract: Prefix searches for directing internet data packets are performed in a prefix search integrated circuit. The integrated circuit includes an array of search engines, each of which accesses a prefix search tree data structure to process a prefix search. An SDRAM is dedicated to each search engine, and SDRAMs share address and control pins to plural search engines on the IC chip. Internal nodes of the tree data structure are duplicated across banks of the SDRAMs to increase bandwidth, and leaf nodes are stored across the SDRAM banks to reduce storage requirements. Within each search engine, data stored in a data register from an SDRAM is compared to a prefix search key stored in a key register. Based on that comparison, an address is calculated to access further tree structure data from the SDRAM. Packet descriptors containing search keys are forwarded to the search engines from an input queue and the search results are forwarded to an output queue, the same packet order being maintained in the two queues.
Type:
Grant
Filed:
July 28, 2003
Date of Patent:
October 31, 2006
Assignee:
Avici Systems
Inventors:
Gregory M. Waters, Larry R. Dennison, Philip P. Carvey, William J. Dally, William F. Mann
Abstract: System, methods and apparatus are applicable to enable owners and vendors of software to protect their intellectual property and other rights in that software. The system also enables vendors or distributors of software to charge per-use for an instance of software. The system produces a unique, unforgeable, tag for every vendor supplied instance (copy) of specific software. Each user device is equipped with a supervising program that ensures, by use of the tag and other information, that no software instance will be used on the device in a manner infringing on the vendor, distributor, or software owner's rights. When installing or using a vendor-supplied software instance, the supervising program verifies the associated tag and stores the tag. When installing or using untagged software, the supervising program fingerprints selected portions of the software and stores the fingerprints. Software is used on a user's device through the supervising program which ensures proper use of the software.