Abstract: A technique for increasing the charge storage capacity of a charge storage device without changing its inherent charge transfer function. The technique may be used to implement a charge domain signal processing circuits such as Analog to Digital Converters (ADCs) used in digital radio frequency signal receivers.

Abstract: The invention is directed to a method of removing a deleterious substance bound to a protein in blood of a patient by introducing a displacer substance into the blood under conditions in which the displacer substance replaces deleterious substance bound to the protein, thereby resulting in additional unbound deleterious substance in the blood, and removing unbound deleterious substance from the blood by extracorporeal renal replacement treatment.

Abstract: A stop collar or like device is formed in one piece to have a portion for a tool to be attached. Movement of the tool allows the collar to be drawn tightly into engagement onto a pipe or other tubular member. A bow centraliser has alternate bows longitudinally offset to reduce initial insertion force. The centraliser may be formed to have end bands of the type used in the stop collar.

Abstract: The present invention is directed to aspartic protease inhibitors represented by the following structural formula (I), or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I). Methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using these aspartic protease inhibitors are also disclosed.

Abstract: An intelligent product catalog system provides for electronic creation, management and viewing of product information using a multimedia display system. A central database repository stores the product information and provides for an unlimited number of product attributes and dynamic reconfiguration of the product information. The central database repository comprises a meta data system, a scheme system and an object model system. A plurality of applications access the central database repository, the applications being automatically adaptive to the dynamic reconfiguration of the product information. A user interface provides display, sorting and filtering of the product information including the unlimited number of product attributes.

Abstract: In one embodiment according to the invention, there is provided a method for generating electrical energy using a thermal cycle of a working gas. The method comprises using the motion of a piston in a cylinder, containing the working gas performing the thermal cycle, to electromagnetically induce current in an electrical circuit coupled to the cylinder; using the electrical circuit to store the electrical energy, produced by the current induced in the electrical circuit, in an electrical storage device; and using the electrical energy stored in the electrical storage device to electromagnetically provide a motive force to the piston. Cyclically using the electrical circuit to store the electrical energy and using the stored energy to provide a motive force to the piston effect a net positive average power transfer into the electrical storage device over the course of the thermal cycle.

Abstract: The invention provides novel, substituted 3-arylamino pyridine compounds pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.

Abstract: The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

Abstract: The present invention relates to a method for producing a fermented food or drink product, including: adding a strain of lactic acid bacteria which belongs to Lactobacillus brevis to a medium containing 50% or more by mass of a vegetative raw material, and either 0.2 to 2.0% by mass of malic acid or 2.0 to 20.0% by mass of fructose, the medium having a pH of 5.0 to 7.0, and the content of the vegetative raw material being expressed by a content thereof in its natural state; and performing fermentation at least until the termination of a logarithmic growth phase of the strain of lactic acid bacteria, wherein an acid or a strain of lactic acid-producing bacteria is additionally added to the medium at any point in time from the initiation of the fermentation until the termination of the logarithmic growth phase, so as to perform the fermentation with a rate of pH reduction of the medium being 0.01 to 0.

Abstract: The invention relates to a method and equipment for performing flow shaping that maintains service quality in packet-switched telecommunications. Using the method according to the invention, the speed properties (OR, PIR, CBS) of an aggregate flow (A) can be monitored and limited in a situation, in which the aggregate flow contains delay-critical traffic (V1), the forwarding of packets representing which cannot be delayed. The invention is based on the fact that, when forwarding packets representing the aggregate flow, a variable is updated, the value of which expresses the earliest permitted moment, at which a packet, representing traffic (V2) other than the delay-critical traffic, can be forwarded. In that case, the transfer speed of the traffic (V2) other than delay-critical traffic adapts to the variations in the transfer speed of the delay-critical traffic, allowing the speed properties of the aggregate flow to be monitored and limited.

Abstract: Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods comprise sandwich assays, and utilize an internal calibration reaction that closely mimics the reaction of test particles by the use of a two-step reaction.

Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.

Abstract: Rectal suppositories are used to administer a predetermined drug dosage to treat a variety of diseases and symptoms in a variety of patient populations. Certain medical conditions, such as digestive disorders, may be more effectively treated when the suppository is placed in a particular location of the patient's anal canal or rectum. A method and apparatus for inserting a suppository into an animal or human may include an applicator having a barrel and plunger. The barrel maintains a first gas flow path during insertion of a suppository and the plunger maintains a second gas flow path during withdrawal of the plunger. By maintaining a first and second gas flow path, trapped air and suction effects on the suppository are minimized or eliminated. Furthermore, patients may immediately resume day-to-day activities. These benefits may encourage patients to maintain a course of treatment thereby potentially avoiding additional complications, hospitalization, and costs.

Abstract: The invention provides methods for treatment of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.

Abstract: Computer method and apparatus provides lightweight stereotypes in a programming model. An alternative to applied profiles is disclosed. A keyword list or list of strings is recorded as an annotation to a model element. The keywords are indicative of applied stereotypes of the model element, where the stereotypes are empty or are used as labels. The list of strings effectively augments the collection of applied stereotypes of the model element.

Abstract: A technique for improving the operation of a Time Interleaved Analog to Digital Converter (TIADC) by suppressing updates and/or correction to updates of an interleave mismatch errors estimator when one or more predetermined conditions indicate such mismatch correction may not improve performance.

Abstract: Authentication of a request for access to user specific information associated with a VoIP device is performed transparently, without any user identification or password required. A unique device identifier associated with the VoIP device is included in the request for access and used as an authentication token.

Abstract: Techniques for detection of impending data errors in a mass storage system, such as a track squeeze problem in an electromagnetic disk drive, and then repairing the impending problem, such as by rewriting the affected tracks. In many cases the problem is detected and repair is effected when the original data can still be read. In other cases, when the data is no longer readable on the disk in question, but when the disk is part of a Redundant Array of Independent Disks (RAID) system, or other system in which higher layer fault tolerance mechanisms are implemented, the missing data can be recovered via these mechanisms. The recovered data is then used to repair the track squeeze problem. The invention can be implemented as firmware in a storage system, as a component of a general purpose operating system, or inside individual disk drives, or it can use a combination of these implementations.

Abstract: An resistor string digital-to-analog converter (DAC) that includes elements to compensate for resistor ladder loading, and/or to provide compensation for loading such as via switch current cancellation. The approach reduces output voltage sensitivity to switch resistances while also reducing INL and DNL errors. Additional resistor loops are optionally disposed at the top and bottom of one or more further segments to provide Nth order resistive current cancellation.

Abstract: The invention features a method of treating an inflammatory condition in an individual, comprising administering an agent inhibits the interaction between a Toll-like receptor 2 (TLR2) and a high mobility group B (HMGB) polypeptide to the individual. The invention also features methods for identifying agents that inhibit the interaction between TLR2 and HMGB.