Patents Represented by Attorney Harold N. Wells
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Patent number: 7713474Abstract: A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.Type: GrantFiled: October 14, 2004Date of Patent: May 11, 2010Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Lloyd S. Schulman, Michael J. Pugia, Spencer Lin, Karlheinz Hildenbrand
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Patent number: 7563621Abstract: A method of applying an organic acid reagent having limited transolubility in organic solvents, aqueous solvents, and mixtures thereof to a component of a diagnostic test device by mixing an organic acid reagent and an amine to form a salt complex, dissolving the salt complex in a solvent to release the organic acid reagent into the solvent, and applying the solvent to the component of the diagnostic test device such that the organic acid reagent present in the solvent becomes integrated into the diagnostic test device. The amine is represented by the formula HmNRn wherein m is 0, 1, or 2; n is 1, 2, or 3; the sum of m and n is 3; and R is an independently selected group which renders the salt complex soluble in aqueous solvents, organic solvents, or mixtures thereof. The amine is also represented by the formula NR4+ wherein R is an independently selected group which renders the salt complex soluble in aqueous solvents, organic solvents, or mixtures thereof.Type: GrantFiled: February 17, 2003Date of Patent: July 21, 2009Assignee: Siemens Healhcare Diagnostics IncInventors: James A Profitt, Alexander H. Orn
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Patent number: 7459127Abstract: A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.Type: GrantFiled: February 26, 2002Date of Patent: December 2, 2008Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, Gert Blankenstein, Ralf-Peter Peters, Holger Bartos
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Patent number: 7435381Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.Type: GrantFiled: May 29, 2003Date of Patent: October 14, 2008Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, James A. Profitt, Ronald G. Sommer, Sung-Kwon Jung
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Patent number: 5811411Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C and are part of an aromatic ring that is thiophene;A is selected from --C(X)-amine, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H.sub.(2-p) --, --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.p --, and --O--;X is O or S;n is 0, 1, 2, or 3;m is 0 or 1;p is 0, 1, or 2;R, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are herein defined;or an agronomic salt thereof.Type: GrantFiled: November 22, 1996Date of Patent: September 22, 1998Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
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Patent number: 5723470Abstract: Novel 3,4,4-trifluorobutenoic acid derivatives of the formula ##STR1## wherein Q is --(C.dbd.W)--R.sub.2 wherein W is O or S, and R.sub.2 is an aliphatic or aromatic group when W.dbd.O; --OR.sub.50 ; --SR.sub.50 ; or --NR.sub.50 R.sub.60 wherein R.sub.60 is hydrogen or R.sub.50 ; NR.sub.7 R.sub.8 ; a heterocyclic group; phenyl substituted by alkyl; or any agronomically acceptable salt thereof having usefulness as nematocides, insecticides and acaricides.Type: GrantFiled: February 12, 1996Date of Patent: March 3, 1998Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
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Patent number: 5714517Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.Type: GrantFiled: August 22, 1996Date of Patent: February 3, 1998Assignee: Monsanto CompanyInventor: Peter Gerrard Ruminski
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Patent number: 5708032Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the structure: ##STR1## where Q is --(C.dbd.S)--R.sub.1 and R.sub.1 is --OR.sub.5, --SR.sub.5, halogen, --NHOH or --NR.sub.5 R.sub.6. Each of R.sub.5 and R.sub.6 is independently hydrogen; an aliphatic or an aromatic group; a C.sub.1 -C.sub.12 aliphatic amine group; a C.sub.2 -C.sub.12 aliphatic carboxylic acid group; or R.sub.5 and R.sub.6 when taken together with the N of R.sub.1 are a protein amino acid or a cyclic group. Polar compounds are particularly useful for systemic control of pests.Type: GrantFiled: May 23, 1995Date of Patent: January 13, 1998Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
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Patent number: 5700475Abstract: Flowable composites are disclosed which comprise a) microcapsules comprising one or more non-aqueous pesticidally active compositions enclosed in an inert water-soluble wall material; b) a non-aqueous liquid in an amount sufficient to maintain the composite flowable; the non-aqueous pesticidally active composition and the non-aqueous liquid being reactive with each other and the inert water-soluble wall material being insoluble in and impermeable to the non-aqueous liquid and the pesticidally active composition. Also disclosed are composites in which the pesticidally active compositions are internally-reactive in the presence of a non-aqueous liquid or solvent. Processes for production of the composites and their utilization as pesticides are also disclosed.Type: GrantFiled: December 29, 1995Date of Patent: December 23, 1997Assignee: Monsanto CompanyInventors: Brent D. Massman, Maria L. Miller
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Patent number: 5700840Abstract: Fluorinated alkene compounds useful for controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the formula BrCF.sub.2 CFClCH.sub.2 CO--R where R is R.sub.1 or R.sub.2. R.sub.1 is --SR.sub.5, halogen, --NHOH or --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 are independently H; an aliphatic or aromatic group; an aliphatic amine group; an aliphatic carboxylic acid group; or R.sub.5 and R.sub.6 when taken with the N of R.sub.1 are an amino acid or a cyclic group or R.sub.1 is --OR.sub.5, where R.sub.5 is an aliphatic or aromatic group; an aliphatic amine group; or an aliphatic carboxylic acid group. R.sub.2 is --SR.sub.5 or --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 are independently H; an aliphatic, aromatic or heterocyclic group; an aliphatic amine group; an aliphatic carboxylic acid group; R.sub.5 and R.sub.6 when taken with the N of R.sub.2 are an amino acid or a cyclic group; R.sub.5 and R.sub.6 when taken with the N of R.sub.Type: GrantFiled: May 23, 1995Date of Patent: December 23, 1997Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
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Patent number: 5693865Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.Type: GrantFiled: December 11, 1996Date of Patent: December 2, 1997Assignee: Monsanto CompanyInventor: Peter Gerrard Ruminski
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Patent number: 5679230Abstract: A electrolytically deposited copper foil has a roughening treatment of copper on the shiny side and on the matte side a fine nodular metal deposit preferably copper or a copper alloy which improves adhesion to a substrate, but is insufficient to increase the measured surface roughness Rz.Type: GrantFiled: August 21, 1995Date of Patent: October 21, 1997Assignee: Oak-Mitsui, Inc.Inventors: John Francis Fatcheric, Derek Charles Carbin
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Patent number: 5597545Abstract: HF can be recovered from aqueous streams, particularly those which are dilute and have a concentration of HF lower than the azeotrope between HF and water. Such aqueous streams are contacted with carbon molecular sieves, preferably those having an average pore size of about 3.5 Angstroms, which adsorb both HF and water. When regenerated by heating, more dilute aqueous streams are desorbed at lower temperatures, followed by desorption of HF which is free of water, making possible a separation of HF and water and avoiding formation of the azeotrope.Type: GrantFiled: November 14, 1994Date of Patent: January 28, 1997Assignee: AlliedSignal Inc.Inventors: Chin-Hsiung Chang, Miguel A. Gualdron
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Patent number: 5587345Abstract: An improved fiber reinforced glass composite includes a carbon fiber in a matrix of a black glass ceramic having the empirical formula SiCxOy where x ranges from about 0.5 to about 2.0, preferably 0.9 to 1.6 and y ranges from about 0.5 to 3.0, preferably 0.7 to 1.8. Preferably the black glass ceramic is derived from cyclosiloxane monomers containing a vinyl group attached to silicon and/or a hydride-silicon group. Graceful failure can be obtained when the carbon fibers are highly graphitized.Type: GrantFiled: June 5, 1995Date of Patent: December 24, 1996Assignee: AlliedSignal Inc.Inventor: Roger Y. Leung
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Patent number: 5580770Abstract: A biologically active support for removing pollutants from a fluid stream such as waste water is prepared. The support is formed of a polymeric foam substrate coated with a composition containing a particulate adsorbent which adsorbs, then releases pollutants, and a polymeric binder that binds the adsorbent to the surface of the substrate. The binder contains a suspension aid, and one or more pollutant-degrading microorganisms are adhered to the surface of the coated support. The binder preferably has a T.sub.g of lower than or equal to about 250.degree. C. and may be a latex. Examples of suspension aids are surfactants and polyanionic polypeptides such as ammonium caseinate. The adsorbent is preferably a carbon material such as coal, charcoal, carbon black and activated carbon. Other adsorbents are silica gel, active clays, zeolites, hydrophobic and ion exchange resins, and molecular sieves.Type: GrantFiled: December 27, 1993Date of Patent: December 3, 1996Assignee: AlliedSignal Inc.Inventor: Louis J. DeFilippi
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Patent number: 5552023Abstract: Recovery of ethylene glycol from dilute aqueous solutions is accomplished by passing the solution over the surface of a porous hydrophobic membrane capable of passing water vapor but not liquid water. The pressure and temperature provide a positive driving force for the movement of water vapor through the membrane to the opposite face where it is removed by condensation or a stream of gas or liquid. Preliminary concentration of the aqueous solutions may be provided by use of reverse osmosis membrane. The method is useful in the reclamation of spent deicing fluid.Type: GrantFiled: December 15, 1993Date of Patent: September 3, 1996Assignee: AlliedSignal Inc.Inventor: Shaojun J. Zhou
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Patent number: 5543052Abstract: Tis invention relates to a process for reducing the concentration of an organic pollutant such as phenol in an aqueous stream which comprises passing the stream through a bioreacter containing a plurality of biologically active particles comprising a hydrophobic polyurethane substrate having an effective amount of one or more aerobic microorganism capable of metabolizing at least one of said organic materials on; in or on and in said substrate in the absence or in the substantial absence of a carbon absorbent.Type: GrantFiled: March 9, 1995Date of Patent: August 6, 1996Assignee: AlliedSignal Inc.Inventors: Francis S. Lupton, William G. Sheridan, Marion R. Surgi
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Patent number: 5539014Abstract: This invention relates to vinyl ether-based coatings for which properties such as color stability, thermal stability, mechanical stability, hydrolytic stability, and resistance to embrittlement may be maintained and properties hydrogen generation and blocking are minimized.Type: GrantFiled: August 19, 1994Date of Patent: July 23, 1996Assignee: AlliedSignal Inc.Inventors: Raymond J. Swedo, George D. Green, James R. Snyder
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Patent number: 5534565Abstract: Epoxy resin compositions used in preparation of laminates for electronic applications are free of the solvents typically needed in current industrial practice. The use of certain mono-substituted dicyandiamides makes possible the elimination of such solvents since all of the components are soluble in epoxy resin to an extent which provides uniform properties in the cured laminates.Type: GrantFiled: April 15, 1994Date of Patent: July 9, 1996Assignee: AlliedSignal Inc.Inventors: Joseph J. Zupancic, Jeffrey P. Conrad, Jiri D. Konicek, Aroon V. Tungare
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Patent number: 5530175Abstract: A method for converting Explosive D, i.e., ammonium picrate to oxygenated products, particularly hydroquinone or cyclohexanediol and ammonia by hydrogenation over a supported Group VIII metal catalyst. Preferably, the ammonium picrate is dissolved in a suitable solvent and then hydrogenated at a temperature of about 25.degree. to 250.degree. C., and a pressure of about 10 to 1000 psig (69 to 6900 kPa gauge) followed by separation of the commercially valuable products and ammonia.Type: GrantFiled: December 22, 1994Date of Patent: June 25, 1996Assignee: AlliedSignal Inc.Inventors: Russell W. Johnson, Robert H. Sedath, Mark B. Koch