Patents Represented by Attorney Harold N. Wells
  • Patent number: 7713474
    Abstract: A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: May 11, 2010
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Lloyd S. Schulman, Michael J. Pugia, Spencer Lin, Karlheinz Hildenbrand
  • Patent number: 7563621
    Abstract: A method of applying an organic acid reagent having limited transolubility in organic solvents, aqueous solvents, and mixtures thereof to a component of a diagnostic test device by mixing an organic acid reagent and an amine to form a salt complex, dissolving the salt complex in a solvent to release the organic acid reagent into the solvent, and applying the solvent to the component of the diagnostic test device such that the organic acid reagent present in the solvent becomes integrated into the diagnostic test device. The amine is represented by the formula HmNRn wherein m is 0, 1, or 2; n is 1, 2, or 3; the sum of m and n is 3; and R is an independently selected group which renders the salt complex soluble in aqueous solvents, organic solvents, or mixtures thereof. The amine is also represented by the formula NR4+ wherein R is an independently selected group which renders the salt complex soluble in aqueous solvents, organic solvents, or mixtures thereof.
    Type: Grant
    Filed: February 17, 2003
    Date of Patent: July 21, 2009
    Assignee: Siemens Healhcare Diagnostics Inc
    Inventors: James A Profitt, Alexander H. Orn
  • Patent number: 7459127
    Abstract: A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: December 2, 2008
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Michael J. Pugia, Gert Blankenstein, Ralf-Peter Peters, Holger Bartos
  • Patent number: 7435381
    Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: October 14, 2008
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Michael J. Pugia, James A. Profitt, Ronald G. Sommer, Sung-Kwon Jung
  • Patent number: 5811411
    Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C and are part of an aromatic ring that is thiophene;A is selected from --C(X)-amine, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H.sub.(2-p) --, --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.p --, and --O--;X is O or S;n is 0, 1, 2, or 3;m is 0 or 1;p is 0, 1, or 2;R, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are herein defined;or an agronomic salt thereof.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: September 22, 1998
    Assignee: Monsanto Company
    Inventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
  • Patent number: 5723470
    Abstract: Novel 3,4,4-trifluorobutenoic acid derivatives of the formula ##STR1## wherein Q is --(C.dbd.W)--R.sub.2 wherein W is O or S, and R.sub.2 is an aliphatic or aromatic group when W.dbd.O; --OR.sub.50 ; --SR.sub.50 ; or --NR.sub.50 R.sub.60 wherein R.sub.60 is hydrogen or R.sub.50 ; NR.sub.7 R.sub.8 ; a heterocyclic group; phenyl substituted by alkyl; or any agronomically acceptable salt thereof having usefulness as nematocides, insecticides and acaricides.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: March 3, 1998
    Assignee: Monsanto Company
    Inventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
  • Patent number: 5714517
    Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: February 3, 1998
    Assignee: Monsanto Company
    Inventor: Peter Gerrard Ruminski
  • Patent number: 5708032
    Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the structure: ##STR1## where Q is --(C.dbd.S)--R.sub.1 and R.sub.1 is --OR.sub.5, --SR.sub.5, halogen, --NHOH or --NR.sub.5 R.sub.6. Each of R.sub.5 and R.sub.6 is independently hydrogen; an aliphatic or an aromatic group; a C.sub.1 -C.sub.12 aliphatic amine group; a C.sub.2 -C.sub.12 aliphatic carboxylic acid group; or R.sub.5 and R.sub.6 when taken together with the N of R.sub.1 are a protein amino acid or a cyclic group. Polar compounds are particularly useful for systemic control of pests.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: January 13, 1998
    Assignee: Monsanto Company
    Inventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
  • Patent number: 5700840
    Abstract: Fluorinated alkene compounds useful for controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the formula BrCF.sub.2 CFClCH.sub.2 CO--R where R is R.sub.1 or R.sub.2. R.sub.1 is --SR.sub.5, halogen, --NHOH or --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 are independently H; an aliphatic or aromatic group; an aliphatic amine group; an aliphatic carboxylic acid group; or R.sub.5 and R.sub.6 when taken with the N of R.sub.1 are an amino acid or a cyclic group or R.sub.1 is --OR.sub.5, where R.sub.5 is an aliphatic or aromatic group; an aliphatic amine group; or an aliphatic carboxylic acid group. R.sub.2 is --SR.sub.5 or --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 are independently H; an aliphatic, aromatic or heterocyclic group; an aliphatic amine group; an aliphatic carboxylic acid group; R.sub.5 and R.sub.6 when taken with the N of R.sub.2 are an amino acid or a cyclic group; R.sub.5 and R.sub.6 when taken with the N of R.sub.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 23, 1997
    Assignee: Monsanto Company
    Inventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
  • Patent number: 5700475
    Abstract: Flowable composites are disclosed which comprise a) microcapsules comprising one or more non-aqueous pesticidally active compositions enclosed in an inert water-soluble wall material; b) a non-aqueous liquid in an amount sufficient to maintain the composite flowable; the non-aqueous pesticidally active composition and the non-aqueous liquid being reactive with each other and the inert water-soluble wall material being insoluble in and impermeable to the non-aqueous liquid and the pesticidally active composition. Also disclosed are composites in which the pesticidally active compositions are internally-reactive in the presence of a non-aqueous liquid or solvent. Processes for production of the composites and their utilization as pesticides are also disclosed.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: December 23, 1997
    Assignee: Monsanto Company
    Inventors: Brent D. Massman, Maria L. Miller
  • Patent number: 5693865
    Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: December 2, 1997
    Assignee: Monsanto Company
    Inventor: Peter Gerrard Ruminski
  • Patent number: 5679230
    Abstract: A electrolytically deposited copper foil has a roughening treatment of copper on the shiny side and on the matte side a fine nodular metal deposit preferably copper or a copper alloy which improves adhesion to a substrate, but is insufficient to increase the measured surface roughness Rz.
    Type: Grant
    Filed: August 21, 1995
    Date of Patent: October 21, 1997
    Assignee: Oak-Mitsui, Inc.
    Inventors: John Francis Fatcheric, Derek Charles Carbin
  • Patent number: 5597545
    Abstract: HF can be recovered from aqueous streams, particularly those which are dilute and have a concentration of HF lower than the azeotrope between HF and water. Such aqueous streams are contacted with carbon molecular sieves, preferably those having an average pore size of about 3.5 Angstroms, which adsorb both HF and water. When regenerated by heating, more dilute aqueous streams are desorbed at lower temperatures, followed by desorption of HF which is free of water, making possible a separation of HF and water and avoiding formation of the azeotrope.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: January 28, 1997
    Assignee: AlliedSignal Inc.
    Inventors: Chin-Hsiung Chang, Miguel A. Gualdron
  • Patent number: 5587345
    Abstract: An improved fiber reinforced glass composite includes a carbon fiber in a matrix of a black glass ceramic having the empirical formula SiCxOy where x ranges from about 0.5 to about 2.0, preferably 0.9 to 1.6 and y ranges from about 0.5 to 3.0, preferably 0.7 to 1.8. Preferably the black glass ceramic is derived from cyclosiloxane monomers containing a vinyl group attached to silicon and/or a hydride-silicon group. Graceful failure can be obtained when the carbon fibers are highly graphitized.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 24, 1996
    Assignee: AlliedSignal Inc.
    Inventor: Roger Y. Leung
  • Patent number: 5580770
    Abstract: A biologically active support for removing pollutants from a fluid stream such as waste water is prepared. The support is formed of a polymeric foam substrate coated with a composition containing a particulate adsorbent which adsorbs, then releases pollutants, and a polymeric binder that binds the adsorbent to the surface of the substrate. The binder contains a suspension aid, and one or more pollutant-degrading microorganisms are adhered to the surface of the coated support. The binder preferably has a T.sub.g of lower than or equal to about 250.degree. C. and may be a latex. Examples of suspension aids are surfactants and polyanionic polypeptides such as ammonium caseinate. The adsorbent is preferably a carbon material such as coal, charcoal, carbon black and activated carbon. Other adsorbents are silica gel, active clays, zeolites, hydrophobic and ion exchange resins, and molecular sieves.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: December 3, 1996
    Assignee: AlliedSignal Inc.
    Inventor: Louis J. DeFilippi
  • Patent number: 5552023
    Abstract: Recovery of ethylene glycol from dilute aqueous solutions is accomplished by passing the solution over the surface of a porous hydrophobic membrane capable of passing water vapor but not liquid water. The pressure and temperature provide a positive driving force for the movement of water vapor through the membrane to the opposite face where it is removed by condensation or a stream of gas or liquid. Preliminary concentration of the aqueous solutions may be provided by use of reverse osmosis membrane. The method is useful in the reclamation of spent deicing fluid.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: September 3, 1996
    Assignee: AlliedSignal Inc.
    Inventor: Shaojun J. Zhou
  • Patent number: 5543052
    Abstract: Tis invention relates to a process for reducing the concentration of an organic pollutant such as phenol in an aqueous stream which comprises passing the stream through a bioreacter containing a plurality of biologically active particles comprising a hydrophobic polyurethane substrate having an effective amount of one or more aerobic microorganism capable of metabolizing at least one of said organic materials on; in or on and in said substrate in the absence or in the substantial absence of a carbon absorbent.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: August 6, 1996
    Assignee: AlliedSignal Inc.
    Inventors: Francis S. Lupton, William G. Sheridan, Marion R. Surgi
  • Patent number: 5539014
    Abstract: This invention relates to vinyl ether-based coatings for which properties such as color stability, thermal stability, mechanical stability, hydrolytic stability, and resistance to embrittlement may be maintained and properties hydrogen generation and blocking are minimized.
    Type: Grant
    Filed: August 19, 1994
    Date of Patent: July 23, 1996
    Assignee: AlliedSignal Inc.
    Inventors: Raymond J. Swedo, George D. Green, James R. Snyder
  • Patent number: 5534565
    Abstract: Epoxy resin compositions used in preparation of laminates for electronic applications are free of the solvents typically needed in current industrial practice. The use of certain mono-substituted dicyandiamides makes possible the elimination of such solvents since all of the components are soluble in epoxy resin to an extent which provides uniform properties in the cured laminates.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: July 9, 1996
    Assignee: AlliedSignal Inc.
    Inventors: Joseph J. Zupancic, Jeffrey P. Conrad, Jiri D. Konicek, Aroon V. Tungare
  • Patent number: 5530175
    Abstract: A method for converting Explosive D, i.e., ammonium picrate to oxygenated products, particularly hydroquinone or cyclohexanediol and ammonia by hydrogenation over a supported Group VIII metal catalyst. Preferably, the ammonium picrate is dissolved in a suitable solvent and then hydrogenated at a temperature of about 25.degree. to 250.degree. C., and a pressure of about 10 to 1000 psig (69 to 6900 kPa gauge) followed by separation of the commercially valuable products and ammonia.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: June 25, 1996
    Assignee: AlliedSignal Inc.
    Inventors: Russell W. Johnson, Robert H. Sedath, Mark B. Koch