Patents Represented by Attorney, Agent or Law Firm Harris F. Brotman
  • Patent number: 5801193
    Abstract: Methods and compounds for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of a compound of the following formula ##STR1## where R is H, PO.sub.3.sup.=, alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH.sub.2).sub.n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH.sub.2).sub.n COOR.sub.2 where n=1-4where R.sub.2 is H, an alkalai metal salt, an alkaline earth metal salt, NH.sub.4.sup.+, N.sup.+ (R.sub.3).sub.4 where R.sub.3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms,COR.sub.1 wherein R.sub.1 is selected from the group consisting of H, (CH.sub.2).sub.n CH.sub.3, where n=1-6, (CH.sub.2).sub.n COOR.sub.2 where n=1-4 and R.sub.2 is previously defined, (CH.sub.2).sub.n N.sup.+ (R.sub.3).sub.4 wherein n=1-4, and (CH.sub.2).sub.n SO.sub.3.sup.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: September 1, 1998
    Assignee: Immune Modulation, Inc.
    Inventors: Emmanuel A. Ojo-Amaize, Joseph I. Okogun, Howard B. Cottam
  • Patent number: 5747270
    Abstract: An in vitro method for diagnosing hypersensitivity to silicon(e) antigen in subjects not previously exposed to silicon(e). The method involves obtaining a subset of lymphocytes from non-sensitized subjects and contacting the lymphocytes with silicon(e) for a sufficient period of time to cause sensitizing and proliferative responses.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: May 5, 1998
    Assignee: Specialty Laboratories, Inc.
    Inventor: Emmanuel Ojo-Amaize
  • Patent number: 5747474
    Abstract: Methods for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of the cyclic AMP agent HE-33 or its nucleoside.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: May 5, 1998
    Assignee: Immune Modulation, Inc.
    Inventors: Emmanuel A. Ojo-Amaize, Howard B. Cottam, Ganesh D. Kini
  • Patent number: 5727348
    Abstract: A portable remotely controlled automatic door closing apparatus enables the door of a room or office to be closed from a remote location within the room or office by transmitting a signal to an actuator which exerts a force on the door to move it from an opened position to a closed position. The apparatus comprises a battery or AC powered motor which moves a lever arm into engagement with the door to rotate the door about its hinges from the open to the closed position. The apparatus is free standing and immobilized on the floor in a non-connected relationship thereto between an adjacent wall and the door in its open position. The apparatus is immobilized to prevent slipping by a floor-engaging mechanism, such as an adhesive, an anti-skid rubber material, or suction cups, or carpet engaging projections.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: March 17, 1998
    Inventors: Louis G. Arnell, Leon Arnell, Thomas P. Sturges
  • Patent number: 5672172
    Abstract: A surgical instrument comprising a probe for insertion into the body of a host and for manipulating the tissues of the host, the probe including an ultrasound transducer element for locating and positioning the probe within the body of the host; and a method for manipulating the tissues of a host using the surgical instrument.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 30, 1997
    Assignee: Vros Corporation
    Inventor: Paul F. Zupkas
  • Patent number: 5653244
    Abstract: A therapeutic compression garment made of flexible, foldable, light weight Velcro-type loop fabric having a central region for wrapping partially around a body part and a plurality of pairs of bands integrally connected to the central region and extending outwardly in opposite directions from both sides of the central region to encompass the body part.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: August 5, 1997
    Assignee: Circaid Medical Products, Inc.
    Inventor: Sandra Anne Shaw
  • Patent number: 5418157
    Abstract: Genetically engineered E. coli carry vectors containing inserts that code for Clostridium histolyticum collagenase. These inserts code for: (a) a form of collagenase having a molecular weight of about 68,000 daltons in the essential absence of larger forms of collagenase; (b) the 68 kd form of collagenase and a fusion polypeptide consisting of the collagenase protein fused to at least a portion of the .beta.-galactosidase protein of E. coli or (3) the 68 kd form of collagenase and polypeptides of molecular weight of from above about 68,000 daltons to about 100,000 daltons and having the enzymatic activity of C. histolyticum collagenase as indicated by digestion of .sup.3 H-acetylated collagen and by specific inhibition by 1,10-phenanthroline plus EDTA. The collagenase genes in the transformed E. coli are expressed efficiently in the transformed cells to yield enzymatically active and immunologically cross-reactive collagenase.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: May 23, 1995
    Inventors: Hun-Chi Lin, Shau-Ping Lei
  • Patent number: 5337480
    Abstract: A device for subdividing a workpiece, typically a citrus fruit, into segments. The device comprises a blade support structure having an opening with a plurality of blades sharpened on two edges projecting from the circumferential surface of the opening toward the middle to juxtapose attacking points and edges forming a channel through which a plunger mechanism urges the workpiece into contact with the attacking points and sharpened edges thereby subdividing the workpiece into segments.
    Type: Grant
    Filed: May 7, 1993
    Date of Patent: August 16, 1994
    Inventor: Ralph Codikow
  • Patent number: 5234824
    Abstract: The present invention provides a method for rapidly obtaining substantially pure DNA from a biological sample containing cells. The method involves gently lysing the membranes of the cells to yield a lysate containing genomic DNA in a high molecular weight form. The lysate is moved through a porous filter to selectively trap the high molecular weight DNA on the filter. The DNA is released from the filter using an aqueous solution to form a solution containing substantially purified DNA, from which the DNA may analyzed or recovered.
    Type: Grant
    Filed: June 2, 1992
    Date of Patent: August 10, 1993
    Assignee: Specialty Laboratories, Inc.
    Inventor: Kary B. Mullis
  • Patent number: D398478
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: September 22, 1998
    Inventor: Richard Randall Spencer